Abstract:This study aimed to assess the impact of extensively drug-resistant (XDR) phenotype on mortality in Pseudomonas aeruginosa bacteremia. A retrospective cohort study was performed in a tertiary hospital from January 2000 to December 2018. All consecutive prospectively recorded P. aeruginosa bacteremia in adult patients were assessed. In this study, 382 patients were included, of which 122 (31.9%) due to XDR P. aeruginosa. Independent factors associated with 14-day mortality were as follows: high-risk source of b… Show more
“…18 P aeruginosa is a versatile bacterium that poses challenges to clinicians due to its exceptional ability to develop additional resistance by the selection of gene mutation and selection of multidrug resistance status. 24 While previous studies identified a higher mortality rate among patients with MDR P aeruginosa BSIs than non-MDR, our study did not find any statistically significant difference. 25,26 In our study, 34.8% of the tested P aeruginosa isolates were resistant to imipenem, and 35.2% were resistant to meropenem.…”
Section: Discussioncontrasting
confidence: 95%
“…A retrospective study by Tumbarello et al reported 12.5% of P aeruginosa BSIs as MDR based on the same criteria we used 18 . P aeruginosa is a versatile bacterium that poses challenges to clinicians due to its exceptional ability to develop additional resistance by the selection of gene mutation and selection of multidrug resistance status 24 . While previous studies identified a higher mortality rate among patients with MDR P aeruginosa BSIs than non‐MDR, our study did not find any statistically significant difference 25,26 …”
Background
Pseudomonas aeruginosa (P aeruginosa) is a leading cause of nosocomial bloodstream infections worldwide. This study aimed to evaluate the incidence of P aeruginosa bloodstream infections and to identify predictors of 30‐day mortality.
Methods
A retrospective study was conducted in an academic tertiary hospital in Jordan. The medical records of patients hospitalised over ten years (1 January 2008‐31 December 2017) were reviewed to identify patients' positive blood culture of P aeruginosa. Annual incidence, antimicrobial susceptibility patterns and risk factors for 30‐day mortality were analysed.
Results
A total of 169 cases of P aeruginosa bloodstream infection were identified, with an overall incidence rate of 0.23 case/1000 admission. The overall crude 30‐day mortality was 36.7%. Receipt of corticosteroids (OR = 4.5; P = .0017), severe sepsis and septic shock (OR = 2.7; P = .0476), admission to intensive care unit (OR = 5.9; P = .0004), end‐stage renal disease (OR = 4.1; P = .0123), inappropriate empirical therapy (OR = 3.2; P = .0143) and inappropriate definitive therapy (OR = 2.9; P = .0110) were identified as independent risk factors for mortality.
Conclusion
The annual incidence of P aeruginosa BSIs was fluctuating over ten years period. Several predictors for 30‐day mortality in patients with P aeruginosa BSIs were identified, including inappropriate empirical and definitive therapy.
“…18 P aeruginosa is a versatile bacterium that poses challenges to clinicians due to its exceptional ability to develop additional resistance by the selection of gene mutation and selection of multidrug resistance status. 24 While previous studies identified a higher mortality rate among patients with MDR P aeruginosa BSIs than non-MDR, our study did not find any statistically significant difference. 25,26 In our study, 34.8% of the tested P aeruginosa isolates were resistant to imipenem, and 35.2% were resistant to meropenem.…”
Section: Discussioncontrasting
confidence: 95%
“…A retrospective study by Tumbarello et al reported 12.5% of P aeruginosa BSIs as MDR based on the same criteria we used 18 . P aeruginosa is a versatile bacterium that poses challenges to clinicians due to its exceptional ability to develop additional resistance by the selection of gene mutation and selection of multidrug resistance status 24 . While previous studies identified a higher mortality rate among patients with MDR P aeruginosa BSIs than non‐MDR, our study did not find any statistically significant difference 25,26 …”
Background
Pseudomonas aeruginosa (P aeruginosa) is a leading cause of nosocomial bloodstream infections worldwide. This study aimed to evaluate the incidence of P aeruginosa bloodstream infections and to identify predictors of 30‐day mortality.
Methods
A retrospective study was conducted in an academic tertiary hospital in Jordan. The medical records of patients hospitalised over ten years (1 January 2008‐31 December 2017) were reviewed to identify patients' positive blood culture of P aeruginosa. Annual incidence, antimicrobial susceptibility patterns and risk factors for 30‐day mortality were analysed.
Results
A total of 169 cases of P aeruginosa bloodstream infection were identified, with an overall incidence rate of 0.23 case/1000 admission. The overall crude 30‐day mortality was 36.7%. Receipt of corticosteroids (OR = 4.5; P = .0017), severe sepsis and septic shock (OR = 2.7; P = .0476), admission to intensive care unit (OR = 5.9; P = .0004), end‐stage renal disease (OR = 4.1; P = .0123), inappropriate empirical therapy (OR = 3.2; P = .0143) and inappropriate definitive therapy (OR = 2.9; P = .0110) were identified as independent risk factors for mortality.
Conclusion
The annual incidence of P aeruginosa BSIs was fluctuating over ten years period. Several predictors for 30‐day mortality in patients with P aeruginosa BSIs were identified, including inappropriate empirical and definitive therapy.
“…The primary site of infection was defined as the most possible source of infection responsible for P. aeruginosa bacteremia on the basis of medical records, including lung infection, soft-tissue infection, biliary tract infection, urinary tract infection, catheter-related infection and peritoneum infection. 23 It was defined as the bacteremia of unknown origin when the source of the infection was unclear. 23 Nosocomial infection was defined as the P. aeruginosa bacteremia (1) that occurred more than 48 h after admission to hospital, or (2) that occurred less than 48 h after admission to hospital in cases who had been hospitalized in other hospitals within the 2 weeks prior to admission.…”
Section: Methodsmentioning
confidence: 99%
“… 23 It was defined as the bacteremia of unknown origin when the source of the infection was unclear. 23 Nosocomial infection was defined as the P. aeruginosa bacteremia (1) that occurred more than 48 h after admission to hospital, or (2) that occurred less than 48 h after admission to hospital in cases who had been hospitalized in other hospitals within the 2 weeks prior to admission. 16 , 17 Community-acquired infection was defined as the P. aeruginosa bacteremia that occurred less than 48 h after admission to hospital in patients who had never been in hospital or nursing home.…”
Purpose
Pseudomonas aeruginosa bacteremia presents a severe challenge to hospitalized patients. However, to date, the risk factors for mortality among inpatients with
P. aeruginosa
bacteremia in China remain unclear.
Patients and Methods
This retrospective multicenter study was performed to analyze 215 patients with culture-confirmed
P. aeruginosa
bacteremia in five healthcare centers in China during the years 2012–2019.
Results
Of 215 patients with
P. aeruginosa
bacteremia, 61 (28.4%) died during the study period. Logistic multivariable analysis revealed that cardiovascular disease (OR=3.978,
P
=0.001), blood transfusion (OR=5.855,
P
<0.001) and carbapenem-resistant
P. aeruginosa
(CRPA) phenotype (OR=4.485,
P
=0.038) constituted the independent risk factors of mortality. Furthermore, both CRPA and multidrug-resistant
P. aeruginosa
(MDRPA) phenotypes were found to be significantly associated with 5-day mortality (Log-rank,
P
<0.05).
Conclusion
This study revealed a high mortality rate amongst hospitalized patients with
P. aeruginosa
bacteremia, and those with cardiovascular diseases, CRPA and MDRPA phenotypes, should be highlighted and given appropriate management in China.
“…Infection epidemiology in hospitalized patients has exhibited a changing profile in the last few decades in Brazil, with significant increases in Gram-negative bacilli (GNB), as well as a progressive rise in multidrug-resistant (MDR) strains. For this reason, inappropriate empirical antibiotic treatment of patients presenting infection by multidrugresistance bacteria has become a major challenge [1][2][3]. Information regarding the current impact of inappropriate therapy on patients with nosocomial infection, however, is lacking.…”
Introduction. Carbapenem-resistant
Pseudomonas aeruginosa
is responsible for increased patient mortality.
Gap Statement. Five and 30 day in-hospital all-cause mortality in patients with
P. aeruginosa
infections were assessed, followed by evaluations concerning potential correlations between the type III secretion system (TTSS) genotype and the production of metallo-β-lactamase (MBL).
Methodology. This assessment comprised a retrospective cohort study including consecutive patients with carbapenem-resistant infections hospitalized in Brazil from January 2009 to June 2019. PCR analyses were performed to determine the presence of TTSS-encoding genes and MBL genes.
Results. The 30-day and 5-day mortality rates for 262 patients were 36.6 and 17.9 %, respectively. The unadjusted survival probabilities for up to 5 days were 70.55 % for patients presenting exoU-positive isolates and 86 % for those presenting exo-negative isolates. The use of urinary catheters, as well as the presence of comorbidity conditions, secondary bacteremia related to the respiratory tract, were independently associated with death at 5 and 30 days. The exoS gene was detected in 64.8 % of the isolates, the presence of the exoT and exoY genes varied and exoU genes occurred in 19.3 % of the isolates. The exoU genotype was significantly more frequent among multiresistant strains. MBL genes were not detected in 92 % of the isolates.
Conclusions. Inappropriate therapy is a crucial factor regarding the worse prognosis among patients with infections caused by multiresistant
P. aeruginosa
, especially those who died within 5 days of diagnosis, regardless of the genotype associated with TTSS virulence.
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