Risk factors for mortality among COVID-19 patients

Albitar, Orwa; Ballouze, Rama; Ooi, Jer Ping; Ghadzi, Siti Maisharah Sheikh

doi:10.1016/j.diabres.2020.108293

Cited by 200 publications

(243 citation statements)

References 34 publications

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“…In 1.0 Gy group, both patients who were discharged had no underlying medical condition, whereas others who died had at least one of the comorbidities that are considered risk factors for COVID-19 mortality. 10 Considering a RR of 80% and CR of 75%, WLI with a single dose of 0.5 Gy demonstrated encouraging results. 7 In this updated report, however, the RR and CR of 1.0 Gy-WLI were 25 and 50%, respectively.…”

Section: Discussionmentioning

confidence: 90%

Low-dose Whole-lung Irradiation for COVID-19 Pneumonia: What is the Optimal Dose? Final Results of a Pilot Study

Ameri¹,

Ameri²,

Rahnama³

et al. 2020

Preprint

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Purpose: Novel coronavirus disease (COVID-19) is the current global concern. Radiotherapy (RT), commonly employed in cancer management, has been considered one of the potential treatments for COVID-19 pneumonia. Here, we present the final report of the pilot trial evaluating the efficacy and safety of low-dose whole-lung irradiation (LD-WLI) in patients with COVID-19 pneumonia. Methods and Materials: We enrolled patients with moderate COVID-19 pneumonia who were older than 60 years. Participants were treated with LD-WLI in a single fraction of 0.5 or 1.0Gy along with the national protocol of COVID-19. The primary endpoints were improvement of SpO2, the number of hospital/ICU stay days, and the number of intubations after RT and the secondary endpoints were alterations of the c-reactive peptide, interleukin-6, ferritin, procalcitonin, and D-dimer. The response rate (RR) was defined as a rise in SpO2 upon RT with rising or constant trend in the next two days, and clinical recovery (CR) included patients who were discharged from the hospital or acquired SpO2 ≥93% on room air. Results: Between 21 May 2020 and 2 July 2020, ten patients were enrolled. The median age was 75 years, 80% were male, and 80% had comorbidities. The first five patients received a single 0.5Gy-WLI, and others received 1.0Gy. Patients were followed for 2-14 days (median 5.5 days). Following one day, nine patients experienced an improvement in SpO2. Five patients were discharged (median 6th day, range 2nd-14th day), and four patients died (median 7th day, range 3rd-10th day). Overall, the RR and CR were 60.0% and 55.5%, respectively. The RR and CR rates of 0.5- and 1.0Gy group were 80% vs 40% and 75% vs 40%, respectively. No acute radiation-induced toxicity was recorded. Conclusions: LD-WLI with a single 0.5Gy fraction seems to be a more appropriate dose to warrant further evaluation in a large-scale, randomized trial.

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Section: Discussionmentioning

confidence: 90%

Low-dose Whole-lung Irradiation for COVID-19 Pneumonia: What is the Optimal Dose? Final Results of a Pilot Study

Ameri¹,

Ameri²,

Rahnama³

et al. 2020

Preprint

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“…The knowledge, attitude, and prevention practice toward COVID-19 is an important issue because studies reported as they have to have health impact on COVID-19. [14][15][16] We had intentionally excluded children and adolescents less than 18 years and patients with a severe and uncorrectable cognitive, visual, or hearing impairment were excluded from the study as we wanted to assess the KAP of the patients and not their parents. The present study found about 68.66% of the study participants have moderate and good knowledge.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 Knowledge, Attitudes, and Prevention Practices Among People with Hypertension and Diabetes Mellitus Attending Public Health Facilities in Ambo, Ethiopia

Taye¹,

Bose²,

Beressa³

et al. 2020

IDR

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Background: To confirm effective preventive practice and reduce the risk of COVID-19 data on knowledge, attitude, and preventive practices (KAP) are essential. Therefore, the current study was designed to evaluate the KAP of COVID-19 among people with hypertension (HTN) and/or diabetes mellitus (DM) attending public health facilities in Ambo town. Patients and Methods: Institutional-based cross-sectional study design was done among patients with HTN and/or DM from June 2020 to September 2020 at Ambo University Referral Hospital (AURH) and Ambo General Hospital (AGH). To identify the associated factors with poor practice and knowledge, logistic regression analyses were used. Results: The mean age of the study respondents was 44.6 years (± 9.84) of which the majority were male 235 (55.6%) and 159 (37.59%) of the participants had good knowledge. Concerning attitude, 335 (79.2%) have strongly believed that DM and HTN patients were more at risk of death because of COVID-19. Only 44 (10.4%) of them had a good level of COVID-19 prevention practice measures. Patients who use the source of information daily were 54.4% less likely to have poor knowledge about COVID-19 than those who use it weekly. Participants with no formal education were 3 times more likely to have poor COVID-19 prevention practice than those who were with formal education, and participants who have poor knowledge about COVID-19 were 2 times more likely to have poor COVID-19 prevention practice than those who have knowledge. Conclusion: The prevalence of poor knowledge about COVID-19 was low, and only less than ¾ of the participants strongly believed COVID-19 as a serious disease. A small percentage of participants had a good level of COVID-19 prevention practice. Good knowledge had an association with a good level of prevention practice. So, health sectors should work to increase accessibility of COVID-19 information.

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“…Our results indicate a very modest progression of retinopathy in both cohorts, suggesting that it can be possible to conduct a safe and effective screening program even with screening at intervals of > 1 year. With regards to safety in the current healthcare environment, healthcare providers also need to consider risk factors for severe coronavirus disease 2019 (COVID-19) infection as many patients with diabetes have multiple risk factors for COVID-19, such as older age, male gender, obesity and hypertension [ 28 ]. In this perspective, extending intervals for screening DR may reduce unnecessary exposure of vulnerable patients to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).…”

Section: Discussionmentioning

confidence: 99%

Screening for Diabetic Retinopathy with Extended Intervals, Safe and Without Compromising Adherence: A Retrospective Cohort Study

2020

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Risk factors for mortality among COVID-19 patients

Cited by 200 publications

References 34 publications

<strong>Low-dose Whole-lung Irradiation for COVID-19 Pneumonia: What is the Optimal Dose? Final Results of a Pilot Study</strong>

<strong>Low-dose Whole-lung Irradiation for COVID-19 Pneumonia: What is the Optimal Dose? Final Results of a Pilot Study</strong>

<p>COVID-19 Knowledge, Attitudes, and Prevention Practices Among People with Hypertension and Diabetes Mellitus Attending Public Health Facilities in Ambo, Ethiopia</p>

Screening for Diabetic Retinopathy with Extended Intervals, Safe and Without Compromising Adherence: A Retrospective Cohort Study

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