Risk Factors for Metastatic Disease at Presentation with Osteosarcoma

Miller, Benjamin J.; Cram, Peter; Lynch, Charles F.; Buckwalter, Joseph A.

doi:10.2106/jbjs.l.01189

Cited by 150 publications

(141 citation statements)

References 26 publications

(50 reference statements)

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“…Despite remarkable advances in the combined used of chemotherapy, radiotherapy and surgical ablation of the primary tumor, survival rates have yet to improve over those of the 1970s (3). Approximately 40% to 50% of patients develop metastasis, often pulmonary metastasis, even after curative resection of the primary tumor, and the 5-year survival rate of osteosarcoma patients with metastases is even lower than 30% (4)(5)(6). Accordingly, the leading cause of fatal outcomes in relapsed osteosarcoma is tumor metastasis.…”

Section: Introductionmentioning

confidence: 99%

Hypoxia-Induced WSB1 Promotes the Metastatic Potential of Osteosarcoma Cells

et al. 2015

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Intratumoral hypoxia occurs in many solid tumors, where it is associated with the development of metastatic character. However, the connections between these phenomena are not fully understood. In this study, we define an integrative role for the E3 ubiquitin ligase subunit WSB1. In primary osteosarcomas, increased levels of WSB1 correlated with pulmonary metastatic potential. RNAi-mediated attenuation of WSB1 or disruption of its E3 ligase activity potently suppressed tumor metastasis. Quantitative proteomic and functional analyses revealed that WSB1 ubiquitylates the Rho-binding protein RhoGDI2 and promotes its proteasomal degradation, thereby activating Rac1 to stimulate tumor cell motility and invasion. Our findings show how WSB1 regulates key steps of the metastatic cascade in hypoxia-driven osteosarcoma, and they highlight a candidate therapeutic target to potentially improve the survival of patients with metastatic disease. Cancer Res; 75(22); 4839-51. Ó2015 AACR.

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Section: Introductionmentioning

confidence: 99%

Hypoxia-Induced WSB1 Promotes the Metastatic Potential of Osteosarcoma Cells

et al. 2015

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“…Extremity and head and neck bone sarcomas commonly have a more favorable prognosis than axial tumors, partially explained by earlier detection, expeditious treatment, and fewer metastases at presentation [3]. It is neither clear, nor is it within the scope of this report, how or why survival in cranial mesenchymal chondrosarcoma is so agedependent.…”

Section: Where Do We Need To Go?mentioning

confidence: 82%

CORR Insights®: Survival in Mesenchymal Chondrosarcoma Varies Based on Age and Tumor Location: A Survival Analysis of the SEER Database

Miller

2017

Clinical Orthopaedics &Amp; Related Research

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“…Compared to patients with low poverty, high‐poverty patients were more likely to reside in counties in which usually were lower health insurance coverage, diminished access to health care providers and fewer oncologist, all of which were related to a delay in diagnosis and higher risk of early death. Indeed, a delay in diagnosis substantially increases the risk of an advanced stage of disease at presentation, which is significantly associated with decreased survival 29, 30, 31, 32. However, with the increasing improvement of health care policies and medical insurance, the patients with low income could also have access to medical consultation and better treatment resources, thereby they could have a progress survival over time 33, 34…”

Section: Discussionmentioning

confidence: 99%

Increased survival of patients aged 0‐29 years with osteosarcoma: A period analysis, 1984‐2013

Sun

et al. 2018

Cancer Medicine

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PurposeOsteosarcoma is the most common primary malignancy of bone, and typically occurs among children and adolescence. This study aims to evaluate treatment outcomes among children, adolescents and young adults with osteosarcoma over the three decades by the changes in the long‐term relative survival.MethodsOsteosarcoma incidence and relative survival data from Surveillance, Epidemiology, and End Results (SEER) registries during 1984‐2013 were analyzed. The survival differences over three decades, age, sex, race, and socioeconomic status (SES) were assessed by comparing Kaplan‐Meier curves.ResultsThe overall incidence of osteosarcoma kept relatively stable with 0.4 per 100 000 in the three decades with the peak incidence occurring in the aged 10‐19 group. The 10‐year relative survival rate (RSR) increased from 57.7% to 61.0% in the three decades, with the greatest increase in the aged 0‐9 group from 48.2% to 65.7%. The 10‐year RSR improved from 54.1% to 61.5% in males, and from 62.4% to 63.0% in females, respectively, in the three decades. Furthermore, survival dramatically improved from 30% to 60% in the high‐poverty group over the three decades.ConclusionThis study demonstrated that the overall incidence of osteosarcoma remained stable, with an improvement in survival in the three decades. The improved survival was greater in males than in females in the three decades. Furthermore, the survival significantly increased in high‐poverty group, which was attributed to increasing improved health care system and patients with low finance can also have access to receiving effective and consistent treatment without distinction.

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Risk Factors for Metastatic Disease at Presentation with Osteosarcoma

Cited by 150 publications

References 26 publications

Hypoxia-Induced WSB1 Promotes the Metastatic Potential of Osteosarcoma Cells

Hypoxia-Induced WSB1 Promotes the Metastatic Potential of Osteosarcoma Cells

CORR Insights®: Survival in Mesenchymal Chondrosarcoma Varies Based on Age and Tumor Location: A Survival Analysis of the SEER Database

Increased survival of patients aged 0‐29 years with osteosarcoma: A period analysis, 1984‐2013

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