Risk Factors for Metachronous Lesions After Gastric Endoscopic or Surgical Resection - A Systematic Review And Meta-Analysis

Ortigão, Raquel; Figueirôa, Gonçalo; Pimentel‐Nunes, Pedro; Dinis‐Ribeiro, Mário; Libânio, Diogo

doi:10.1055/s-0041-1724574

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“…A review on the latter topic is available in the literature (180). In gastric adenocarcinomas, high levels of COX-2 expression are linked to lymph node metastasis and depth of invasion, suggesting that prostanoids generated by this enzyme increase the aggressive behavior of these tumors (16). COX-2 expression is particularly high in GC, and it is also higher in dysplastic lesions compared with normal mucosal tissue, revealing the contribution of COX-2 in gastric carcinogenesis even at the preinvasive state (16).…”

Section: Cyclooxygenase-2 Role In Gastritisassociated Inflammationmentioning

confidence: 99%

“…In gastric adenocarcinomas, high levels of COX-2 expression are linked to lymph node metastasis and depth of invasion, suggesting that prostanoids generated by this enzyme increase the aggressive behavior of these tumors (16). COX-2 expression is particularly high in GC, and it is also higher in dysplastic lesions compared with normal mucosal tissue, revealing the contribution of COX-2 in gastric carcinogenesis even at the preinvasive state (16). Concerning its association with microbiota, full induction of this enzyme has been demonstrated to be dependent on direct bacterial contact, a functional T4SS system, and epidermal growth factor receptor (EGFR) activation (181).…”

Section: Cyclooxygenase-2 Role In Gastritisassociated Inflammationmentioning

confidence: 99%

“…In fact, in Europe and according to published guidelines the endoscopic surveillance of patients diagnosed with stomach precancerous conditions/lesions is endorsed as a strategy to detect GC when minimally invasive treatment is possible (14). However, the upper gastrointestinal (GI) endoscopy is still associated with a non-negligible rate of missed conditions (about 9.4 %), as reported in the systematic review and meta-analysis by Pimenta-Melo et al (15), and the minimally invasive removal of early lesions is associated with a significant risk of metachronous lesions development (16). In the Era of Personalized Medicine, should other biomarkers besides age, sex, family history and morphology/ histology be added to the equation?…”

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Linking dysbiosis to precancerous stomach through inflammation: Deeper than and beyond imaging

et al. 2023

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Upper gastrointestinal endoscopy is considered the gold standard for gastric lesions detection and surveillance, but it is still associated with a non-negligible rate of missing conditions. In the Era of Personalized Medicine, biomarkers could be the key to overcome missed lesions or to better predict recurrence, pushing the frontier of endoscopy to functional endoscopy. In the last decade, microbiota in gastric cancer has been extensively explored, with gastric carcinogenesis being associated with progressive dysbiosis. Helicobacter pylori infection has been considered the main causative agent of gastritis due to its interference in disrupting the acidic environment of the stomach through inflammatory mediators. Thus, does inflammation bridge the gap between gastric dysbiosis and the gastric carcinogenesis cascade and could the microbiota-inflammation axis-derived biomarkers be the answer to the unmet challenge of functional upper endoscopy? To address this question, in this review, the available evidence on the role of gastric dysbiosis and chronic inflammation in precancerous conditions of the stomach is summarized, particularly targeting the nuclear factor-κB (NF-κB), toll-like receptors (TLRs) and cyclooxygenase-2 (COX-2) pathways. Additionally, the potential of liquid biopsies as a non-invasive source and the clinical utility of studied biomarkers is also explored. Overall, and although most studies offer a mechanistic perspective linking a strong proinflammatory Th1 cell response associated with, but not limited to, chronic infection with Helicobacter pylori, promising data recently published highlights not only the diagnostic value of microbial biomarkers but also the potential of gastric juice as a liquid biopsy pushing forward the concept of functional endoscopy and personalized care in gastric cancer early diagnosis and surveillance.

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Section: Cyclooxygenase-2 Role In Gastritisassociated Inflammationmentioning

confidence: 99%

Section: Cyclooxygenase-2 Role In Gastritisassociated Inflammationmentioning

confidence: 99%

mentioning

confidence: 99%

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Linking dysbiosis to precancerous stomach through inflammation: Deeper than and beyond imaging

et al. 2023

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Risk Factors for Metachronous Lesions After Gastric Endoscopic or Surgical Resection - A Systematic Review And Meta-Analysis

Cited by 1 publication

References 0 publications

Linking dysbiosis to precancerous stomach through inflammation: Deeper than and beyond imaging

Linking dysbiosis to precancerous stomach through inflammation: Deeper than and beyond imaging

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