Risk factors for mechanical ventilation in children with <scp>Guillain‐Barré</scp> syndrome

Luo, Hanyu; Hong, Siqi; Li, Mei; Wang, Li; Jiang, Li

doi:10.1002/mus.26905

Cited by 12 publications

(11 citation statements)

References 28 publications

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“…Regarding EDx results, we found no difference in GBS subtypes in the group with respiratory failure, which is consistent with some studies ( Green, Baker & Subramaniam, 2018 ; Parveen et al, 2020 ) but contradicts others where a higher proportion of demyelinating ( Durand et al, 2006 ; Yamagishi et al, 2017 ) or axonal GBS subtypes was found ( Shangab & Al Kaylani, 2021 ; Walgaard et al, 2010 ; Islam et al, 2019 ; Luo et al, 2020 ).…”

Section: Discussionsupporting

confidence: 90%

“…However, the multivariate analysis showed that the only significant predictors were bulbar palsy (AOR 10.4) and weakness of hip flexors of MRC ≤ 3 (AOR 31.4). By comparison, bulbar weakness was a significant predictor of respiratory failure in several studies ( Malaga et al, 2021 ; Kanikannan et al, 2014 ; Toamad et al, 2015 ; Wu et al, 2015 ; Green, Baker & Subramaniam, 2018 ; Islam et al, 2019 ; Umer et al, 2019 ; Luo et al, 2020 ; Ning et al, 2020 ). Although the short time from symptom onset to admission (≤7 days) was a significant predictor in several studies ( Rantala et al, 1995 ; Toamad et al, 2015 ; Wu et al, 2015 ; Green, Baker & Subramaniam, 2018 ; Umer et al, 2019 ; Luo et al, 2020 ), it did not reach statistical significance in our univariate and multivariate analyses.…”

Section: Discussionmentioning

confidence: 92%

“…By comparison, bulbar weakness was a significant predictor of respiratory failure in several studies ( Malaga et al, 2021 ; Kanikannan et al, 2014 ; Toamad et al, 2015 ; Wu et al, 2015 ; Green, Baker & Subramaniam, 2018 ; Islam et al, 2019 ; Umer et al, 2019 ; Luo et al, 2020 ; Ning et al, 2020 ). Although the short time from symptom onset to admission (≤7 days) was a significant predictor in several studies ( Rantala et al, 1995 ; Toamad et al, 2015 ; Wu et al, 2015 ; Green, Baker & Subramaniam, 2018 ; Umer et al, 2019 ; Luo et al, 2020 ), it did not reach statistical significance in our univariate and multivariate analyses. This may be because our hospital is a tertiary hospital, and some patients were referred from community hospitals, so our hospital admission date may not be the date of initial hospital admission.…”

Section: Discussionmentioning

confidence: 92%

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Clinical predictors and electrodiagnostic characteristics in patients with Guillain-Barré syndrome with respiratory failure: a retrospective, matched case-control study

Charoentanyarak

Singjam

Saengsuwan

2022

PeerJ

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Background Respiratory failure is a common complication of Guillain-Barré syndrome (GBS). This study aimed to determine the clinical predictors and electrodiagnostic (EDx) characteristics in patients with Guillain-Barré syndrome (GBS) with respiratory failure. Methods The retrospective study included 29 confirmed GBS cases with respiratory failure and age- (±5 years) and sex-matched controls (1:1). The dependent t-test and McNemar–Bowker test were used to analyse the continuous and categorical data, respectively. In addition, a multiple logistic regression analysis was used to analyse the predictive factors for respiratory failure. Results Among both cases and controls, the majority were male (72.4%), and the average age was 50.9 years. The data showed that patients with respiratory failure had higher GBS disability scores, lower motor power (≤3) of the hip flexors and ankle dorsiflexors, and experienced facial and bulbar palsy. In the multivariate analysis, the significant predictive factors were bulbar palsy (AOR 10.4 [95% CI [2.6–41.4]) and motor power of hip flexors ≤ 3 (AOR 31.4 [95% CI [3.1–314.5]). Patients with respiratory failure had lower compound muscle action potential amplitude of the ulnar and tibial nerves. The median, ulnar, and tibial nerve conduction studies were more likely to reflect inexcitability. The GBS subtypes in GBS patients with and without respiratory failure were not significantly different. Conclusions Bulbar palsy and motor power of the hip flexors ≤ 3 were significant predictors for respiratory failure. The GBS subtypes in patients with and without respiratory failure were not significantly different.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 92%

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Clinical predictors and electrodiagnostic characteristics in patients with Guillain-Barré syndrome with respiratory failure: a retrospective, matched case-control study

Charoentanyarak

Singjam

Saengsuwan

2022

PeerJ

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“…Similar to adult cohorts, requirement for mechanical ventilation in pediatric patients has been associated with facial weakness, cranial nerve involvement, more severe muscle weakness, time from symptom onset to admission, axonal variant GBS, and dysautonomia. 32,56,57 Reported prognosis was not as favorable in a study of a pediatric cohort from Abbreviations: EGOS, Erasmus Guillain-Barre Syndrome Outcome Score; GBS, Guillain-Barre syndrome. Predictions corresponding to these prognostic scores range from 1 to 52% for the inability to walk independently at 6 months.…”

Section: Prognosis In Pediatric Populationsmentioning

confidence: 99%

Neuroprognostication: Guillain–Barré Syndrome

Traub,

Chaudhry

2023

Semin Neurol

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Guillain–Barré syndrome is an immune-mediated disease of the peripheral nerves characterized by rapidly progressing symmetric weakness, areflexia, and albuminocytological dissociation. Most patients reach their nadir within 2 weeks. Disease severity can be mild to severe, with 20% of patients requiring mechanical ventilation. Intravenous immunoglobulin and plasma exchange are equally effective treatments. Monitoring strength, respiratory function, blood pressure, and heart rate, as well as pain management and rehabilitative therapy are important aspects of management. About 20% of patients require assistance to walk at 6 months. Older age, preceding diarrhea, and lower Medical Research Council (MRC) sum scores predict poor outcome. Death from cardiovascular and respiratory complications can occur in the acute or recovery phases of the illness in 3 to 7% of the patients. Risk factors for mortality include advanced age and disease severity at onset. Neuropathic pain, weakness, and fatigue can be residual symptoms; risk factors for these include axonal loss, sensory involvement, and severity of illness.

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“…In this disease, autonomic dysfunction is common but rarely lasts more than one or two weeks [3]. There is no definitive cure for Guillain-Barre, but there are ways to improve symptoms, most of which include IVIG and plasmapheresis [4,5]. Guillain-Barre syndrome is an autoimmune disorder characterized by a group of different clinical and pathological findings.…”

Section: Introductionmentioning

confidence: 99%

Clinical Features of Guillain-Barre Syndrome in COVID-19 Patients: Aria and Naft Private Hospitals in Ahvaz, Iran

Bahramy¹,

Roozdar-Chaleshtary²,

Abbasi³

et al. 2021

Entomol. Appl. Sci. Lett.

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Given the importance of rapid diagnosis and rejection of multiple possible diagnoses and selection of appropriate treatment for Guillain-Barre syndrome in COVID-19 patients, the present descriptive crosssectional study investigated the clinical features of Guillain-Barre syndrome in COVID-19 patients. The statistical population of the present study was all Guillain-Barre patients with COVID-19 referred to Aria and Naft private hospitals in Ahvaz in 2020 and 2021. The data collection tool was a researcher-made checklist. Paired t-test and Chi-square test were used to determine the relationship between variables. Data was analyzed using SPSS24 software. The mean age of patients was 47 years. A high percentage of patients had paresthesia (87.5%) lower limb weakness and upper limb weakness was 75%. After hospitalization, 62.5% (5 patients) received IVIg, 12.5% (one patient) received plasmapheresis, and 25% (2 patients) received physiotherapy. Spinal fluid protein was in the range of 45-110 and cell count was in the normal range. IVIg treatment was 0.4 gr / kg / d for 5 days. Based on the results, it is recommended that IVIg treatment is considered along with other COVID-19 specific therapies. In addition, during the COVID-19 pandemic, an increase in GBS was observed in Khuzestan province, indicating the role of COVID-19 in GBS. It is necessary to hold educational courses to enhance information about this disease and its relevant symptoms and conduct studies with a larger sample of patients with COVID-19 at the national and provincial level.

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Risk factors for mechanical ventilation in children with Guillain‐Barré syndrome

Cited by 12 publications

References 28 publications

Clinical predictors and electrodiagnostic characteristics in patients with Guillain-Barré syndrome with respiratory failure: a retrospective, matched case-control study

Clinical predictors and electrodiagnostic characteristics in patients with Guillain-Barré syndrome with respiratory failure: a retrospective, matched case-control study

Neuroprognostication: Guillain–Barré Syndrome

Clinical Features of Guillain-Barre Syndrome in COVID-19 Patients: Aria and Naft Private Hospitals in Ahvaz, Iran

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