Risk Factors for Male Lower Urinary Tract Symptoms: The Role of Metabolic Syndrome and Androgenetic Alopecia in a Latin American Population

Barbosa, João Arthur Brunhara Alves; Muracca, Eduardo; Nakano, Elcio; Paranhos, Mario; Natalino, Renato José Mendonça; Cordeiro, Paulo; Srougi, Miguel; Antunes, Alberto A.

doi:10.1016/j.urology.2013.03.001

Cited by 15 publications

(11 citation statements)

References 31 publications

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“…Furthermore, it is important to note that patients with a higher WHR had a higher frequency of symptoms than those with a WHR ≤0.9 after pairing by age. The outcomes of this multivariate analysis are consistent with the conclusions of most other studies, namely that central obesity, as determined by the WHR, increases the risk for LUTS …”

Section: Discussionsupporting

confidence: 89%

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Central obesity indicating a higher prevalence of lower urinary tract symptoms: A case‐control matching analysis from a Chinese cross‐sectional study in males

Xie

Chen

Gao

et al. 2018

LUTS

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Objective The aim of this study was to explore the association between central obesity and lower urinary tract symptoms (LUTS) among men in southern China, and test the hypothesis that central obesity measured by the waist-to-hip ratio (WHR) is a predictor of the severity of LUTS. Methods In all, 4303 men from the Fangchenggang Area Male Healthy and Examination Survey (FAMHES) were included in this study. LUTS were assessed by the International Prostate Symptom Score (IPSS), whereas central obesity was evaluated by the WHR. The association between WHR and LUTS was tested using logistic and Cox regression analyses. Results After screening, 2917 participants were in the study. Univariate analysis indicated significant differences in WHR in the presence of LUTS (P = .012). After stratification by age, logistic regression indicated that LUTS were more frequent in 60-year-old men with a higher WHR (odds ratio [OR] 2.89, 95% confidence interval [CI] 1.21-6.89) compared with participants <40 years old. Cox regression analysis after pairing of 252 LUTS cases and 252 control subjects from the 2917 eligible participants according to age (±5 years), indicated that central obesity (WHR ≥0.9) may be significantly associated with moderate or severe LUTS (OR 1.95, 95% CI 1.16-3.26). The associations between central obesity and straining (OR 2.44, 95% CI 1.40-4.24) and weak stream (OR 2.37, 95% CI 1.27-4.45) were significant after multivariate adjustment. Conclusions Males with central obesity are at increased risk of LUTS, and increased WHR is associated with worsened straining and weak stream. Further investigations are needed to confirm these associations.

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Section: Discussionsupporting

confidence: 89%

“…Age is an important factor for LUTS, as noted in most studies . In another study, elevated WHR predicted moderate or severe LUTS independent of age . In the present study, after stratification by age, we found that LUTS were more frequent in the group with a higher WHR and age ≥60 years.…”

Section: Discussionsupporting

confidence: 78%

Central obesity indicating a higher prevalence of lower urinary tract symptoms: A case‐control matching analysis from a Chinese cross‐sectional study in males

Xie

Chen

Gao

et al. 2018

LUTS

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“…Similar to other studies, our data showed an increase in the prevalence of moderate to severe LUTS with advancing age. The prevalence of LUTS in our study was much lower compared with other studies based in Europe [ 3 – 5 , 7 , 14 ], the US [ 6 ], South America [ 18 ], Hong Kong [ 12 ] and other Asian countries [ 3 , 10 ], especially among people aged over 50 years. Nevertheless, a similar prevalence was found between this study and another 2 population-based studies in Norway [ 8 ] and Singapore [ 9 ], for men who were younger than 50 and 70 years, respectively.…”

Section: Discussioncontrasting

confidence: 82%

Prevalence and risk factors of lower urinary tract symptoms in Chinese adult men: a multicentre cross-sectional study

et al. 2017

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There has been no previous population-based study reporting the prevalence and risk factors of male lower urinary tract symptoms (LUTS) among men in mainland China. This cross-sectional study was conducted from 2013 to 2014 in three representative provinces of China: Guangdong, Hubei and Jiangsu. 3250 individuals participated in the interviews, which involved a questionnaire covering sociodemographic characteristics, lifestyle, dietary patterns and the International Prostate Symptom Score (IPSS). Blood was collected for lipids, glucose, insulin and reproductive hormone tests. The incidences of LUTS and its obstructive and irritative symptoms were calculated. Risk factors for LUTS were identified using multivariable logistic regression analysis. The prevalence of moderate to severe LUTS and its obstructive and irritative symptoms was 14.3%, 13.1% and 16.1%, respectively, and increased with age. The prevalence in Guangdong was much lower than that in Hubei and Jiangsu in different ages. Increased fasting plasma glucose and decreased HDL-C levels were associated with an increased risk of moderate to severe LUTS (OR = 1.30, 95% CI: 1.02–1.65 and OR = 2.06, 95% CI: 1.08–3.94, respectively). Free testosterone < 0.22 ng/ml decreased the risk of moderate to severe LUTS and obstructive and irritative symptoms by about 20–30%. An inadequate daily intake of vegetables, fruit and water significantly increased the risk of LUTS by 1.3–to 2.0 times. In conclusion, the prevalence of LUTS in Chinese men is high and increases with age. Dietary patterns may be critical for the development of LUTS. Thus, dietary modifications could be a useful strategy for preventing the development of LUTS.

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“…Furthermore, alcohol consumption is still related with improving insulin sensitivity, 9 and then decreased the risk of LUTS according to improving metabolism syndrome which have been widely confirmed as being strongly associated with LUTS. [29][30][31] Apparently, all the above studies presented incomplete consistent results between alcohol consumption and LUTS or its subtypes. It could be attributed to the difference in lifestyle, race, definition of alcohol consumption (quantity or frequency), the range of the subjects (age and number) and adjustment of confounding factors.…”

Section: Discussionmentioning

confidence: 88%

<p>Drinking Frequency but not Years may be Associated with Lower Urinary Tract Symptoms: Result from a Large Cross-Sectional Survey in Chinese Men</p>

Zhang

et al. 2020

RMHP

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To evaluate the effect of the drinking frequency and years on lower urinary tract symptoms (LUTS) in a large Chinese male population. Methods: The current data were obtained from a consecutive series of 3,229 men aged 18-79 who participated in a routine physical examination in Fangchenggang First People's Hospital, Guangxi, China. During a face-to-face interview, the detailed demographic variables about alcohol consumption, potential confounding factors were collected. LUTS were assessed by International Prostate Symptom Score (IPSS) and defined as total LUTS, irritative (IRR) and obstructive (OBS) symptoms, respectively. Multivariate logistic regression analysis was used to evaluate the risk of total LUTS, IRR and OBS symptoms affected by alcohol consumption. Results: The prevalence of moderate to severe LUTS was 8.3% and apparently increased with age (P<0.001). A significant distribution presented in age, alcohol consumption, BMI, cigarette smoking, education attainment and hypertension among different strata of LUTS severity (P<0.05). Men who drank 1-2 times per week were less likely to have OBS symptoms (OR=0.45, 95%CI=0.29-0.70) regardless of age (OR=0.52, 95%CI=0.33-0.82) or multivariate adjusted (OR=0.52, 95%CI=0.33-0.83). Nevertheless, we did not observe a significant negative or positive association presented between drinking years and the risk of total LUTS, OBS and IRR symptoms. Conclusion:The current results imply that moderate drinking frequency may be protective against LUTS, and drinking years did not relate to worsening or improving LUTS.

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Risk Factors for Male Lower Urinary Tract Symptoms: The Role of Metabolic Syndrome and Androgenetic Alopecia in a Latin American Population

Cited by 15 publications

References 31 publications

Central obesity indicating a higher prevalence of lower urinary tract symptoms: A case‐control matching analysis from a Chinese cross‐sectional study in males

Central obesity indicating a higher prevalence of lower urinary tract symptoms: A case‐control matching analysis from a Chinese cross‐sectional study in males

Prevalence and risk factors of lower urinary tract symptoms in Chinese adult men: a multicentre cross-sectional study

<p>Drinking Frequency but not Years may be Associated with Lower Urinary Tract Symptoms: Result from a Large Cross-Sectional Survey in Chinese Men</p>

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