Risk factors for major salivary gland carcinoma. A case-comparison study

Spitz, Margaret R.; Tilley, Barbara C.; Batsakis, John G.; Gibeau, Joanne M.; Newell, Guy R.

doi:10.1002/1097-0142(19841101)54:9<1854::aid-cncr2820540915>3.0.co;2-1

Cited by 82 publications

(64 citation statements)

References 13 publications

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“…20,21 The cancer induction time is relatively long for solid tumours; for exposures during childhood and adolescence, the induction period is 10-35 years. 22 There are a few epidemiological studies on a possible relationship between dental radiography and salivary gland cancer.…”

Section: Discussionmentioning

confidence: 99%

Absorbed organ and effective doses from digital intra-oral and panoramic radiography applying the ICRP 103 recommendations for effective dose estimations

Granlund¹,

Thilander-Klang²,

Ylhan³

et al. 2016

BJR

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Objective: During dental radiography, the salivary and thyroid glands are at radiation risk. In 2007, the International Commission on Radiological Protection (ICRP) updated the methodology for determining the effective dose, and the salivary glands were assigned tissue-specific weighting factors for the first time. The aims of this study were to determine the absorbed dose to the organs and to calculate, applying the ICRP publication 103 tissue-weighting factors, the effective doses delivered during digital intraoral and panoramic radiography. Methods: Thermoluminescent dosemeter measurements were performed on an anthropomorphic head and neck phantom. The organ-absorbed doses were measured at 30 locations, representing different radiosensitive organs in the head and neck, and the effective dose was calculated according to the ICRP recommendations.

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Section: Discussionmentioning

confidence: 99%

Absorbed organ and effective doses from digital intra-oral and panoramic radiography applying the ICRP 103 recommendations for effective dose estimations

Granlund¹,

Thilander-Klang²,

Ylhan³

et al. 2016

BJR

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“…Radiation to the head and neck is one potential cause. A number of studies found an association between external radiation therapy to the head and neck and subsequent development of salivary gland malignancies, especially in children (Maxon et al, 1981;Modan et al, 1974;Palmer et al, 1980;Spitz et al, 1984). A similar association was observed in survivors of the atomic bombing of Japan (Belsky et al, 1975).…”

mentioning

confidence: 86%

Submandibular Gland Adenocarcinoma of Intercalated Duct Origin in Smgb-Tag Mice

Dardick

Paulus

et al. 2000

Laboratory Investigation

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SUMMARY:A line of transgenic mice that develops submandibular gland adenocarcinoma of intercalated duct origin was established. In these mice, the oncogene SV40 T antigen (Tag) is expressed from the neonatal submandibular gland secretory protein b (Smgb) gene promoter. This hybrid gene directs expression of the oncoprotein to neonatal submandibular gland proacinar and terminal tubule cells and to intercalated ducts of the adult gland. Transgene expression resulted in duct luminal cell hyperplasia as early as 20 to 30 days postnatally, which progressed to dysplasia by 3 to 4 months of age. Marked dysplasia and in situ carcinoma were evident at 4 to 6 months of age. All histologic changes were more pronounced in males. Submandibular gland adenocarcinoma developed stochastically in more than half of the adult male mice by 12 months of age (average age: 10.8 months, range: 6 to 13.5 months). Tag expression persisted in in situ carcinoma and all tumors. Using a combination of immunocytochemical and ultrastructural criteria, submandibular gland dysplasia and tumors were found to originate from intercalated ducts. The dysplastic ducts and adenocarcinoma in Smgb-Tag mice were morphologically similar to previously reported Tag-induced dysplasias of striated ducts and granular convoluted tubules and a Tag-induced adenocarcinoma of striated duct origin. These findings demonstrate that salivary gland dysplasias and tumors of similar histologic appearance can arise from distinct differentiated cell types. Analysis of the molecular changes accompanying tumor formation in Smgb-Tag mice could increase knowledge of human salivary gland tumorigenesis. (Lab Invest 2000, 80:1657-1670.

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“…Contrasting from the more common mucosal head and neck cancers, which, in general, are ascribed to excessive tobacco, alcohol use, and more recently to viral infection (HPV), specific carcinogenic factors for malignant salivary gland growths have not been as clearly identified. Exposure to ionizing radiation [2][3][4][5][6][7][8] has been implicated as a cause of salivary gland cancer as well as certain occupational exposures, such as, rubber products manufacturing, asbestos mining, plumbing, and some types of woodworking [9,10].…”

Section: Introductionmentioning

confidence: 99%

Current Thinking on Malignant Salivary Gland Neoplasms

Arrangoiz¹

2013

JCTR

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Abstract:Malignant salivary gland neoplasms are rare, representing approximately 3% to 7% of all head and neck cancers. Contrasting from the more common mucosal head and neck cancers, which, in general, are ascribed to excessive tobacco, alcohol use, and more recently to viral infection, specific carcinogenic factors for malignant salivary gland growths have not been as clearly identified. Histologically, they represent a heterogeneous group of tumors. Forty histologic types of epithelial tumors of the salivary glands have been reported; some are exceedingly rare and may be the topic of only a few case reports. Salivary tumors can arise in the major salivary glands or in one of the minor salivary glands (predominantly mucus secreting glands), which are distributed throughout the upper aerodigestive. Most patients who develop malignant salivary gland tumors are in the sixth or seventh decade of life. FNA should be considered as part of the diagnostic evaluation but due to its varying sensitivities and specificities imaging modalities such as ultrasound, CT scans, and MRI should also be used as diagnostic adjuncts. Surgery is the primary modality for management of these tumors, nontraditional surgical approaches and instrumentation, as well as facial nerve monitoring, can be selectively utilized to try and decrease the morbidity associated with these surgical procedures. Adjuvant treatment is primarily achieved with radiation therapy. Chemotherapy continues to have a palliative role in the management of salivary gland tumors; however, research in this field is trying to identify a therapeutic role for chemotherapy in order to improve overall survival.

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Risk factors for major salivary gland carcinoma. A case-comparison study

Cited by 82 publications

References 13 publications

Absorbed organ and effective doses from digital intra-oral and panoramic radiography applying the ICRP 103 recommendations for effective dose estimations

Absorbed organ and effective doses from digital intra-oral and panoramic radiography applying the ICRP 103 recommendations for effective dose estimations

Submandibular Gland Adenocarcinoma of Intercalated Duct Origin in Smgb-Tag Mice

Current Thinking on Malignant Salivary Gland Neoplasms

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