Risk factors for major blood transfusion during liver transplantation

Abstract

none of control or MP groups. At the end of cold preservation, ATP content was higher in MP group vs. SCS group. After reperfusion, MP livers functioned better (INR, bilirubin) and showed less hepatocellular and endothelial cell injury, in agreement with better preserved liver integrity (histology). MP livers also exhibited higher ATP recovery than SCS livers. The protective effect of Airdrive Ò was associated with attenuation of oxidative and endoplasmic reticulum stress leading to reduced mitochondrial injury and apoptosis.We demonstrate for the first time the efficacy of MP Airdrive Ò device to enhance donor liver viability for transplantation in a clinically relevant DCD model.