Risk Factors for Low Levels of Parathyroid Hormone after Surgery for Thyroid Cancer: A Single Center Study

Privitera, Francesca; Gioco, Rossella; Fazio, Ileana; Volpicelli, Alessio; Cannizzaro, Maria Teresa; Costa, Salvatore P.; Cannizzaro, Matteo Angelo; Veroux, Massimiliano

doi:10.3390/jcm10184113

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…Although female gender was reported as a risk factor for transient hypoparathyroidism in some studies, no correlation was found between hypoparathyroidism and gender in other studies. [ 33 - 35 ]…”

Section: Discussionmentioning

confidence: 99%

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The reality of hypoparathyroidism after thyroidectomy: which risk factors are effective? Single center study

et al. 2022

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Section: Discussionmentioning

confidence: 99%

“…However, there are studies demonstrating no relationship between age and hypoparathyroidism. [ 35 - 37 ]…”

Section: Discussionmentioning

confidence: 99%

The reality of hypoparathyroidism after thyroidectomy: which risk factors are effective? Single center study

et al. 2022

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“…A total of 1743 articles were screened (Figure 1) and 237 full‐text articles were assessed for eligibility. After careful selection of the articles, 66 studies were eligible for the final synthesis and were included in this review 10,14,23,24,27‐88 …”

Section: Resultsmentioning

confidence: 99%

Management of Postthyroidectomy Hypoparathyroidism and Its Effect on Hypocalcemia‐Related Complications: A Meta‐Analysis

van Dijk,

van Driel,

van Kinschot

et al. 2023

Otolaryngol.--head neck surg.

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ObjectiveThe aim of this Meta‐analysis is to evaluate the impact of different treatment strategies for early postoperative hypoparathyroidism on hypocalcemia‐related complications and long‐term hypoparathyroidism.Data SourcesEmbase.com, MEDLINE, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, and the top 100 references of Google Scholar were searched to September 20, 2022.Review MethodsArticles reporting on adult patients who underwent total thyroidectomy which specified a treatment strategy for postthyroidectomy hypoparathyroidism were included. Random effect models were applied to obtain pooled proportions and 95% confidence intervals. Primary outcome was the occurrence of major hypocalcemia‐related complications. Secondary outcome was long‐term hypoparathyroidism.ResultsSixty‐six studies comprising 67 treatment protocols and 51,096 patients were included in this Meta‐analysis. In 8 protocols (3806 patients), routine calcium and/or active vitamin D medication was given to all patients directly after thyroidectomy. In 49 protocols (44,012 patients), calcium and/or active vitamin D medication was only given to patients with biochemically proven postthyroidectomy hypoparathyroidism. In 10 protocols (3278 patients), calcium and/or active vitamin D supplementation was only initiated in case of clinical symptoms of hypocalcemia. No patient had a major complication due to postoperative hypocalcemia. The pooled proportion of long‐term hypoparathyroidism was 2.4% (95% confidence interval, 1.9‐3.0). There was no significant difference in the incidence of long‐term hypoparathyroidism between the 3 supplementation groups.ConclusionsAll treatment strategies for postoperative hypocalcemia prevent major complications of hypocalcemia. The early postoperative treatment protocol for postthyroidectomy hypoparathyroidism does not seem to influence recovery of parathyroid function in the long term.

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Frequency and Risk Factors of Permanent Hypoparathyroidism After Total Thyroidectomy: An Experience at a Tertiary Care Hospital in Pakistan

et al. 2023

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Objectives Thyroid surgeries are among the most common operations performed in the world. Hypocalcemia following total thyroidectomy (TT) is a common complication that is sometimes difficult to correct. This study aims to determine the frequency of hypocalcemia and permanent hypoparathyroidism (PtHPT) following TT. Methods A total of 363 patient records were reviewed who underwent TT for any reason. Thirty-eight patients did not have a follow-up in the clinic in the postoperative period and were excluded from the final analysis with the final sample as 325. For patients who developed hypocalcemia during the postoperative hospital stay, their lowest calcium levels were recorded and medical records were reviewed for the period of one year for the requirement of oral calcium and active form of vitamin D (calcitriol or alpha calcidiol) in the outpatient setting. Patients who required calcium and vitamin D supplementation for up to 1 year were labeled as having PtHPT. Risk factors were analyzed among those who developed PtHPT. Results From a total of 325 patients postoperative hypocalcemia developed in 163 (50.2%) patients, and 162 (49.8%) patients remained normocalcemic. Permanent hypoparathyroidism was found in 42(12.9%) patients and transient HPT in 121 (37.2%). Age, severe postoperative hypocalcemia (PoHC), and readmission for hypocalcemia were independent risk factors for PtHPT. Conclusions Transient hypoparathyroidism (THPT) is common in our setup. Patients who develop severe hypocalcemia postoperatively and need readmission should be closely followed for the development of PtHPT.

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Risk Factors for Low Levels of Parathyroid Hormone after Surgery for Thyroid Cancer: A Single Center Study

Cited by 5 publications

References 35 publications

The reality of hypoparathyroidism after thyroidectomy: which risk factors are effective? Single center study

The reality of hypoparathyroidism after thyroidectomy: which risk factors are effective? Single center study

Management of Postthyroidectomy Hypoparathyroidism and Its Effect on Hypocalcemia‐Related Complications: A Meta‐Analysis

Frequency and Risk Factors of Permanent Hypoparathyroidism After Total Thyroidectomy: An Experience at a Tertiary Care Hospital in Pakistan

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