Risk Factors for Local Recurrence or Metastasis of Eyelid Sebaceous Gland Carcinoma After Wide Excision With Paraffin Section Control

Takahashi, Yasuhiro; Takahashi, Emiko; Nakakura, Shunsuke; Kitaguchi, Yoshiyuki; Mupas-Uy, Jacqueline; Kakizaki, Hirohiko

doi:10.1016/j.ajo.2016.08.028

Cited by 46 publications

(74 citation statements)

References 30 publications

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“…Based upon the known risk factors for poor prognosis of eyelid SCs, (Takahashi et al. ) the present study systematically examined the expression of PD‐L1 in SC tumours using samples with an intensity score of 2+ in at least 1% of the cells being classified as PD‐L1hi, which was previously reported by Twyman‐Saint Victor et al. () as a standardized scoring criteria.…”

Section: Discussionmentioning

confidence: 99%

Programmed death receptor Ligand 1 expression in eyelid sebaceous carcinoma: a consecutive case series of 41 patients

et al. 2018

Acta Ophthalmologica

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Section: Discussionmentioning

confidence: 99%

Programmed death receptor Ligand 1 expression in eyelid sebaceous carcinoma: a consecutive case series of 41 patients

et al. 2018

Acta Ophthalmologica

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“…A higher risk for recurrence or metastasis has been reported in patients with symptoms over 6 months, involvement of both upper and lower eyelids, multicentric origin, diffuse or a non-lobular pattern, pagetoid spread, orbital involvement, perineural invasion and stage T2b (AJCC 7th -edition) or worse [60,61]. In a chinese study of 238 patients, risk factors for tumor-related death were orbital involvement, the greatest tumor basal diameter, pagetoid spread and lymph node metastasis at initial diagnosis [62].…”

Section: Follow-upmentioning

confidence: 99%

Nordic treatment practices survey and consensus for treatment of eyelid sebaceous carcinoma

et al. 2020

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Background: The purpose was to describe the Nordic treatment practices and to reach a Nordic consensus for the treatment of sebaceous eyelid carcinoma. Methods: The treatment practices data was collected by a questionnaire with 37 questions to the Nordic oculoplastic surgeons and analyzed. A PubMed MEDLINE database search was done to gather data on the published treatment practices and recommendations. A working group that consisted of in minimum one senior consultant from each leading Nordic University Eye Hospital was assigned. A structured interactive method was used to establish the consensus. Results: Twenty-four doctors responded to the questionnaire. 23/24 (96%) of the respondents took a biopsy before surgery. Regional lymph node scanning was routinely done by 14/23 (61%) and a systemic screening of a metastatic disease by 13/23 (57%). 6/22 (27%) never took conjunctival mapping biopsies and 12/23 (52%) never screened for Muir-Torre. Respondents used Mohs surgery, frozen section or multi-stage excision with delayed closure, and 5-6 mm was the mostly preferred margin. Sentinel lymph node biopsy was a possible option for 9/22 (41%) and cryotherapy and Mitomycin C for 6/22 (27%) respondents. 50% of respondents considered radiation as a treatment option. 15/16 (94%) respondents always followed-up their patients, most for 5 years. Two thirds scanned regional lymph nodes during the follow-up. Consensus was reached for 18 statements representing three domains: preoperative work-up, treatment and follow-up. Conclusion: Treatment practices differ in between the five Nordic countries which have similar public health care systems. In the article the authors present a Nordic consensus for the treatment of eyelid sebaceous carcinoma.

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“…Twelve clinical series of periocular sebaceous carcinoma with pathological correlations involving 20 or more patients were identified through PubMed between January 2008 and January 2019 (using search terms sebaceous carcinoma, eyelid, periocular, ocular adnexal, pagetoid spread and treatment) (table 1). 12–23 These studies involved 1064 patients, but in only two studies (87 patients) were specific patterns of intraepithelial sebaceous neoplasia described 12 16. Two other studies used the term intraepithelial neoplasia without further clarification,13 21 while eight studies applied the term pagetoid spread without definition or used it interchangeably with intraepithelial neoplasia 14 15 17–20 22 23.…”

Section: Seeds Of Uncertainty Sownmentioning

confidence: 99%

“…Two other studies used the term intraepithelial neoplasia without further clarification,13 21 while eight studies applied the term pagetoid spread without definition or used it interchangeably with intraepithelial neoplasia 14 15 17–20 22 23. In four studies, there were statistically significant associations between pagetoid invasion and an outcome variable 14 17 19 23. In five studies, no associations with local recurrence or mortality were found 12 18 20–22.…”

Section: Seeds Of Uncertainty Sownmentioning

confidence: 99%

Periocular intraepithelial sebaceous neoplasia: critical appraisal of nomenclature and prognostic importance

Margo

2019

J Clin Pathol

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Intraepithelial sebaceous neoplasia in the forms (or subclassification) of pagetoid spread and carcinoma in situ is a common feature of periocular sebaceous carcinoma and is associated with less favourable outcomes. Seminal studies of periocular sebaceous carcinoma in the 1980s indicated that the two patterns of intraepithelial spread had differing influences on prognosis with pagetoid invasion being worse. Later studies reported conflicting results, but careful inspection of those studies revealed considerable variation in what was meant by pagetoid invasion. Different interpretations of pagetoid spread continue, leading to ambiguous results in clinical studies and miscommunication with potential unintended decisions affecting clinical management. This paper reviews the background leading to the frequent interchangeable use of pagetoid spread with in situ sebaceous carcinoma and how this problem confounds interpretation of clinical studies. The author recommends that for effective communication, all morphological patterns of in situ spread of sebaceous carcinoma fall under the term intraepithelial sebaceous neoplasia, which can be accompanied by subclassification whenever desired.

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Risk Factors for Local Recurrence or Metastasis of Eyelid Sebaceous Gland Carcinoma After Wide Excision With Paraffin Section Control

Cited by 46 publications

References 30 publications

Programmed death receptor Ligand 1 expression in eyelid sebaceous carcinoma: a consecutive case series of 41 patients

Programmed death receptor Ligand 1 expression in eyelid sebaceous carcinoma: a consecutive case series of 41 patients

Nordic treatment practices survey and consensus for treatment of eyelid sebaceous carcinoma

Periocular intraepithelial sebaceous neoplasia: critical appraisal of nomenclature and prognostic importance

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