Risk factors for liver-related mortality in chronic hepatitis C patients: A deceased case-living control study

Zeng, Qing‐Lei; Feng, Guohua; Zhang, Jiyuan; Yan, Chun‐Hua; Yang, Bin; Huang, Hui‐Huang; Zhang, Xuexiu; Zhang, Zheng; Wang, Fusheng

doi:10.3748/wjg.v20.i18.5519

Cited by 8 publications

(11 citation statements)

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“…Hepatic fibrosis often occurs and evolves dynamically in the natural course of chronic HCV infection. The presence of advanced fibrosis or cirrhosis has long been recognized as an independent and the most relevant predictor of mortality and server complications in chronic hepatitis C (CHC) patients . On the other hand, a rapid and significant regression of liver fibrosis or cirrhosis may reduce the risk of end‐stage liver disease and hepatocellular carcinoma .…”

Section: Introductionmentioning

confidence: 99%

Characterization of fibrosis changes in chronic hepatitis C patients after virological cure: A systematic review with meta‐analysis

Liu

Wei

Chen

et al. 2017

J of Gastro and Hepatol

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Section: Introductionmentioning

confidence: 99%

Characterization of fibrosis changes in chronic hepatitis C patients after virological cure: A systematic review with meta‐analysis

Liu

Wei

Chen

et al. 2017

J of Gastro and Hepatol

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“…Twenty‐one studies were identified which evaluated the risk of developing DM in HCV‐infected individuals (N = 22 432 including n = 3583 with DM); 14 of them also included a non‐HCV control group . Seven studies were from Japan, three studies from China, one study from Korea, one study from multiple countries, and nine studies were from Taiwan; eighteen studies were cross‐sectional, one was case‐control, and two were prospective cohort studies of incidence of de novo DM (Table S1).…”

Section: Resultsmentioning

confidence: 99%

Systematic review with meta‐analysis: extrahepatic manifestations in chronic hepatitis C virus‐infected patients in East Asia

Younossi

Henry

Ong³

et al. 2019

Aliment Pharmacol Ther

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Background: Although the prevalence of extrahepatic manifestations of chronic hepatitis C virus (HCV) infection has been reported from Western countries, their prevalence in East Asian countries is not well known. Aim:To perform a systematic review to quantify the prevalence of selected extrahepatic manifestations of HCV among patients from East Asia.Methods: Medline, CINAHL, EMBASE, Cochrane and country-specific databases were reviewed according to standard guidelines for meta-analyses. Only articles with patients from East Asian countries were included. Results:After review, 34 articles were selected (Japan = 9; China = 5, Korea = 3, Taiwan = 16, multiple countries = 1) with 646 228 subjects, 66 436 with HCV.Mean age for HCV-infected patients was 56 years (range 41-72 years), 50% were male (range 26%-73%). The pooled prevalence of type 2 diabetes in East Asian HCV patients was 19.0% (95% confidence interval 15.6%-22.9%) (n = 19 studies) with an increased risk when compared to non-HCV: odds ratio (OR) 1.58 (1.28-1.94). The prevalence of chronic kidney disease in HCV was 9.2% (5.0%-16.2%) (n = 7 studies), also with a significantly increased risk: OR=1.98 (1.41-2.77). Pooled prevalence of cardiovascular disease in HCV was 8.6% (3.5%-19.9%) (n = 6 studies), also with an increased risk: OR = 1.55 (1.21-1.98). The prevalence of lichen planus in HCV was 8.9% (3.6%-20.6%) (n = 6 studies) while the prevalence of rheumatoid arthritis was 4.5% (0.6%-25.7%) (n = 4 studies). Conclusions:These data show increased risk of developing extrahepatic manifestations in East Asian patients with HCV. Both hepatic and extrahepatic manifestations of the infection should be used to accurately determine the total burden of the disease in the region.

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“…HCC screening was performed at least every 2 months after the SVR. HCC was confirmed by liver histopathology, at least two imaging tools, or by one imaging diagnostic modality and a serum AFP level of 400 ng/mL or higher 11,12. Alcohol consumption was defined as alcohol consumption on at least 4 days per week for at least 5 years 11,12.…”

Section: Methodsmentioning

confidence: 99%

“…HCC was confirmed by liver histopathology, at least two imaging tools, or by one imaging diagnostic modality and a serum AFP level of 400 ng/mL or higher 11,12. Alcohol consumption was defined as alcohol consumption on at least 4 days per week for at least 5 years 11,12. Ever smokers were defined as patients who had smoked cigarettes at least 4 days per week for at least 5 years 11,12.…”

Section: Methodsmentioning

confidence: 99%

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Clinical Model for Predicting Hepatocellular Carcinomas in Patients with Post-Sustained Virologic Responses of Chronic Hepatitis C: A Case Control Study

Zeng

Zhang

et al. 2016

Gut and Liver

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Background/AimsNo clinical model exists to predict the occurrence of hepatocellular carcinoma in sustained virologic response-achieving (HCC after SVR) patients with chronic hepatitis C (CHC).MethodsWe performed a case-control study using a clinical database to research the risk factors for HCC after SVR. A predictive model based on risk factors was established, and the area under the receiver operating characteristic curve (AUC) was calculated.ResultsIn the multivariate model, an initial diagnosis of compensated cirrhosis and post-SVR albumin reductions of 1 g/L were associated with 21.7-fold (95% CI, 4.2 to 112.3; p<0.001) and 1.3-fold (95% CI, 1.1 to 1.7; p=0.004) increases in the risk of HCC after SVR, respectively. A predictive model based on an initial diagnosis of compensated cirrhosis (yes, +1; no, 0) and post-SVR albumin ≤36.0 g/L (yes, +1; not, 0) predicted the occurrence of HCC after SVR with a cutoff value of >0, an AUC of 0.880, a sensitivity of 0.833, a specificity of 0.896, and a negative predictive value of 0.956.ConclusionsAn initial diagnosis of compensated cirrhosis combined with a post-SVR albumin value of ≤36.0 g/L predicts the occurrence of HCC after SVR in patients with CHC.

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Risk factors for liver-related mortality in chronic hepatitis C patients: A deceased case-living control study

Abstract: This study indicates that interferon-α treatment, the stage at the initial diagnosis of the disease and comorbidities are all independent risk factors for liver-related mortality in CHC patients.

Cited by 8 publications

References 0 publications

Characterization of fibrosis changes in chronic hepatitis C patients after virological cure: A systematic review with meta‐analysis

Characterization of fibrosis changes in chronic hepatitis C patients after virological cure: A systematic review with meta‐analysis

Systematic review with meta‐analysis: extrahepatic manifestations in chronic hepatitis C virus‐infected patients in East Asia

Clinical Model for Predicting Hepatocellular Carcinomas in Patients with Post-Sustained Virologic Responses of Chronic Hepatitis C: A Case Control Study

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