Risk factors for keratinocyte carcinoma skin cancer in nonwhite individuals: A retrospective analysis

Nadhan, Kumar S.; Chung, Christina Lee; Buchanan, Erin Michelle; Shaver, Christine M.; Shipman, Scott A.; Allawh, Rina; Hoffman, Melissa; Lim, Geoffrey F.S.; Abdelmalek, Mark; Cusack, Carrie Ann

doi:10.1016/j.jaad.2019.01.038

Cited by 20 publications

(16 citation statements)

References 11 publications

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“…The overall prevalence of BCC in patients with clinically suspected skin cancer in this study sample was 39.7%. In keeping with international trends, most patients with BCC were male (55.7%) and white ∗ (85.9%) with a median age of 70 years [ 2 , 16 , 17 ]. Data regarding BCC in other population groups in SA are sparse [ 18 , 19 ].…”

Section: Discussionsupporting

confidence: 59%

A Profile and Three-Year Follow-Up of Patients with Basal Cell Carcinoma in the Western Cape, South Africa

Gallo

Schneider

Wet

et al. 2022

Journal of Skin Cancer

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Background. Basal cell carcinoma (BCC) is an important malignancy in sub-Saharan Africa. There is a paucity of data regarding BCC in South Africa. Aims. To describe the clinicopathological features of patients presenting with BCC in a cohort of South African patients. Methods. This retrospective descriptive study reviewed the medical records of 149 patients with BCC who attended the dermatology clinic at Tygerberg Academic Hospital from September 2015 to August 2016. Demographic and clinical data of those patients with histologically proven BCC were retrieved from clinical records. The data included the assessment for BCC recurrence after three years (September 2016–August 2019). Results. Of 390 patients, 155 (39.7%) had histologically confirmed BCCs. Complete medical records were available for 149 of these patients, and most were male (55.7%) and white (85.9%) with a median age of 70 years. Most patients had their BCC lesions for 12 months (43.1%) before diagnosis. BCCs were mostly located on the head and neck area (58.1%). In most patients (72.0%), a diagnostic punch biopsy confirmed BCC. Plastic surgeons subsequently excised the BCC lesions in 74.0% of these patients. The most common histological subtype was nodular BCC (74.0%). The National Comprehensive Cancer Network (NCCN) risk of recurrence was approximately evenly distributed between high- (54.1%) and low-risk groups (45.9%). The major high-risk feature was the location (36.6%). Histologically confirmed BCC recurrence occurred in 9 of the 149 patients (3.7%) over three years. Conclusions. BCC represents a high burden of disease in our setting. Compared to existing studies, the BCCs in this study are clinically and histologically similar to international reports.

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Section: Discussionsupporting

confidence: 59%

A Profile and Three-Year Follow-Up of Patients with Basal Cell Carcinoma in the Western Cape, South Africa

Gallo

Schneider

Wet

et al. 2022

Journal of Skin Cancer

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“…4 Studies outside the Medicare population have often noted a predominance of BCC in younger patients but with widely varying point estimates of the relative burden of BCC to cSCC. [3][4][5] Finally, data on KCs in patients with skin of color in the United States are limited, mostly to regional 6,7 or single-center [8][9][10][11][12][13][14][15] data. Importantly, none of these prior analyses have attempted to simultaneously analyze and adjust their estimates for age, sex, and race; and given that they derive from geographically restricted populations, the geographic variation in the BCC:cSCC ratio is poorly understood.…”

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confidence: 99%

Association of Age, Sex, Race, and Geographic Region With Variation of the Ratio of Basal Cell to Cutaneous Squamous Cell Carcinomas in the United States

et al. 2020

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IMPORTANCE Defining which populations are affected by basal cell carcinoma (BCC) vs cutaneous squamous cell carcinoma (cSCC) may inform targeted public health strategies. Incidence of BCC and cSCC is not reported to national cancer registries, but claims data for the treatment of BCC and cSCC provide insights into the epidemiology of keratinocyte carcinoma.OBJECTIVE To define differences in the ratio of BCC to cSCC in adults (age, Ն18 years) in a large database of patients with commercial insurance and Medicare Advantage coverage. DESIGN, SETTING, AND PARTICIPANTSThis cross-sectional analysis used deidentified data derived from the Optum Clinformatics Data Mart to perform a retrospective evaluation of a large commercially insured cohort based on treatment claims from January 1, 2012, to December 31, 2016. Patients with a diagnosed and treated BCC or cSCC as determined by codes from the

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“…Other cumulative risk factors that are also significant for the development of keratinocytic cancer is immune suppression most often drug-induced in patients with chronic autoimmune diseases, or with postoperative organ transplantation [18]. The role of smoking as a proven carcinogen should not be overlooked, as there is evidence that it increases the risk of developing SCC [19].…”

Section: Discussionmentioning

confidence: 99%

Keratinocytic Cancers - Ambulatory Surgical Approach: Case Series

Angelov¹,

Bitolska²,

Tchernev³

2020

CRDOA

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The Keratinocytic cancer is the most common form of skin cancer and the most common cancer in humans. Predisposing risk factors include ultraviolet radiation, genetic predisposition, chronic immune suppression, smoking, which also determines the risk groups - middle and old age, light skin phenotype, outdoor work and frequent sunburns. The origin of the epidermal cell type determines the clinical division of keratinocytic cancer into basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Clinically, keratinocytic cancer is presented as a solitary, sometimes destructive, growing-sized lesion. The most lesions are characterized by a low degree of malignancy. Neglecting them by both the patient and medical professionals leads to their growth and metastasis, as SCC has a higher potential for metastasis. The main place in the treatment of keratinocytic cancer is the surgical method, and the most common in clinical practice is the so called elliptical excision. The gold standard in hardto-reach places is the Mohs micrographic operation. In this publication we present eleven clinical cases of patients with keratinocytic cancers in different topographic regions of the human body. Patients were treated surgically by elliptical excision and complete removal of tumor formations in accordance with the recommended fields of surgical safety. The defects were closed with single skin sutures and the sutures were removed on the 14th postoperative day. No complications were observed in the postoperative period. Keywords: Keratinocytic Cancer; Basal Cell Carcinoma; Squamous Cell Carcinoma; Elliptical Excision; Dermatosurgery

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Risk factors for keratinocyte carcinoma skin cancer in nonwhite individuals: A retrospective analysis

Cited by 20 publications

References 11 publications

A Profile and Three-Year Follow-Up of Patients with Basal Cell Carcinoma in the Western Cape, South Africa

A Profile and Three-Year Follow-Up of Patients with Basal Cell Carcinoma in the Western Cape, South Africa

Association of Age, Sex, Race, and Geographic Region With Variation of the Ratio of Basal Cell to Cutaneous Squamous Cell Carcinomas in the United States

Keratinocytic Cancers - Ambulatory Surgical Approach: Case Series

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