Risk Factors for Infection Following Total Knee Arthroplasty: A Series of 3836 Cases from One Institution

Bacteriology and risk factors associated with periprosthetic joint infection after primary total knee arthroplasty: retrospective study of 2543 cases

“…Culture-negative periprosthetic joint infection was excluded from this analysis Abbreviations: OR = odds ratio; CI = confidence interval; TKA = total knee arthroplasty * Excluded from the multivariable regression model because of poor goodness-of-fit keeping with the current literature. 6,8,11 Although various authors have found male sex to be a risk factor for PJI, 4,19,20 the association was not significant in this study. The OR of 1.9 may be of clinical importance but not significant as a result of the small number of PJIs and inadequate statistical power.…”

“…Coagulase-negative staphylococci were the most common causative organism in one study. 4 In contrast, in our series, S aureus was the most common causative organism, particularly methicillin-sensitive strains. Methicillin-resistant strains were less common in our series, constituting 39% of all staphylococcal organisms.…”

“…The OR of 1.9 may be of clinical importance but not significant as a result of the small number of PJIs and inadequate statistical power. The correlation between age and PJI has been a matter of controversy, with some reports mentioning young age as a risk factor for PJI 4,21 and some otherwise. 22 In our study, age was not associated with PJI occurrence.…”

“…Rheumatoid arthritis was a significant risk factor for periprosthetic joint infection. for PJI after elective total joint replacement, [4][5][6][7][8][9][10][11][12][13][14] with the aim of further reducing the incidence of PJI. However, local data on the risk factors and bacteriological features associated with PJI are still lacking.…”

“…4,16 In our study, skin flora and gram-positive bacteria were the most commonly isolated organisms, followed by gram-negative bacteria such as Escherichia coli and Salmonella. Coagulase-negative staphylococci were the most common causative organism in one study.…”