Risk Factors for Incident Dementia Among Older Cubans

Peeters, Geeske; Sanchez, Arianna Almirall; Guerra, Jorge Llibre; Lawlor, Brian; Kenny, Rose Anne; Yaffe, Kristine; Rodriguez, Juan J. Llibre

doi:10.3389/fpubh.2020.00481

Cited by 8 publications

(6 citation statements)

References 44 publications

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“…Similar association studies also reported from other LMICs (51) and HICs (52). A recent study showed the age-specific effect of stroke on dementia, particularly in the younger age group (38). Stroke is the leading health problem in Indonesia since it occupied the first rank of cause of death in our national basic health research (RISKESDAS) in 2013 and 2018, which is 7 and 10.9%, respectively (53,54).…”

Section: Health Factorssupporting

confidence: 73%

“…High cholesterol in late life can indicate a better nutritional status and better overall health, and therefore, it was associated with less cognitive decline (36,37). Several possible mechanisms may explain the abovementioned phenomena (38). Risk factors may occur across the life span, and they take time to affect health in general and the brain in particular.…”

Section: Age-dependent Risk Factors For Cognitive Decline/dementiamentioning

confidence: 99%

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Dementia Prevalence, Comorbidities, and Lifestyle Among Jatinangor Elders

et al. 2021

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Introduction: Research on dementia prevalence and the potentially related risk factors from Indonesia is scarce. We sought to identify the prevalence of dementia, health risk factors, and lifestyle in Jatinangor elders.Methods: A total of 686 participants completed questionnaires on lifestyle, health risk factors, and cognitive and functional tests from September 2013 to December 2013. We determined the prevalence of dementia; and the associations between health, leisure activities, dietary pattern, and dementia were analyzed using logistic regression.Results: The prevalence of dementia was 29.15%. The risk factors differed between age groups. Those aged 60–74 years and who have a lower education level, lower occupational attainment, and less active intellectual and recreational activities were associated with higher dementia risk. Those aged > 75 years living in a rural area and who take less fruit were associated with a higher risk of dementia.Conclusions: The prevalence of dementia in Jatinangor is high. The identified modifiable risk factors are a potential target for intervention and valuable for designing public health policies.

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Section: Health Factorssupporting

confidence: 73%

Section: Age-dependent Risk Factors For Cognitive Decline/dementiamentioning

confidence: 99%

Dementia Prevalence, Comorbidities, and Lifestyle Among Jatinangor Elders

et al. 2021

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“…Database searches identified 16 324 articles, of which 15 658 were excluded based on title and abstract screening (figure 1). We assessed 666 full-text articles, 58 of which reported a study that fulfilled the inclusion criteria 9 11 12 15 32–85. Overall, studies included 257 983 (range: 67–81 087), 128 261 (range: 300–71 157) and 33 870 (range: 638–20 639) participants for all-cause dementia, Alzheimer’s disease and vascular dementia outcomes, respectively.…”

Section: Resultsmentioning

confidence: 99%

Physical activity as a protective factor for dementia and Alzheimer’s disease: systematic review, meta-analysis and quality assessment of cohort and case–control studies

et al. 2022

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ObjectivePhysical activity (PA) is associated with a decreased incidence of dementia, but much of the evidence comes from short follow-ups prone to reverse causation. This meta-analysis investigates the effect of study length on the association.DesignA systematic review and meta-analysis. Pooled effect sizes, dose–response analysis and funnel plots were used to synthesise the results.Data sourcesCINAHL (last search 19 October 2021), PsycInfo, Scopus, PubMed, Web of Science (21 October 2021) and SPORTDiscus (26 October 2021).Eligibility criteriaStudies of adults with a prospective follow-up of at least 1 year, a valid cognitive measure or cohort in mid-life at baseline and an estimate of the association between baseline PA and follow-up all-cause dementia, Alzheimer’s disease or vascular dementia were included (n=58).ResultsPA was associated with a decreased risk of all-cause dementia (pooled relative risk 0.80, 95% CI 0.77 to 0.84, n=257 983), Alzheimer’s disease (0.86, 95% CI 0.80 to 0.93, n=128 261) and vascular dementia (0.79, 95% CI 0.66 to 0.95, n=33 870), even in longer follow-ups (≥20 years) for all-cause dementia and Alzheimer’s disease. Neither baseline age, follow-up length nor study quality significantly moderated the associations. Dose–response meta-analyses revealed significant linear, spline and quadratic trends within estimates for all-cause dementia incidence, but only a significant spline trend for Alzheimer’s disease. Funnel plots showed possible publication bias for all-cause dementia and Alzheimer’s disease.ConclusionPA was associated with lower incidence of all-cause dementia and Alzheimer’s disease, even in longer follow-ups, supporting PA as a modifiable protective lifestyle factor, even after reducing the effects of reverse causation.

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“…One limitation in this study is that about 35% (N = 475) of the eligible sample were lost to follow-up or were not included in the analysis due to incomplete data, similar to other LMIC cohorts (45). The main reason was mass migration from the city due to consecutive years of frequent flooding between 2012 and 2014.…”

Section: Limitationsmentioning

confidence: 98%

Dementia Incidence, Burden and Cost of Care: A Filipino Community-Based Study

Dominguez

Jiloca

Fowler

et al. 2021

Front. Public Health

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Background: In the midst of competing priorities and limited resources in low-middle-income countries (LMIC), convincing epidemiological evidence is critical for urging governments to develop national dementia plans. The majority of primary epidemiological studies on dementia are from high income countries (HIC). Implications for developing countries are typically extrapolated from these outcomes through modeling, meta-analyses, and systematic reviews. In this study, we directly assessed the incidence of dementia, disability adjusted life years (DALYs), and cost of care among community-dwelling Filipino elderly.Methods: This was a follow-up study of the prospective cohort Marikina Memory Ageing Project (MMAP). Baseline assessment was performed in 2011–2012, and follow-up was done in 2015–2016 (N = 748 at follow-up). Incident dementia was determined. Disease burden was computed using the incidence rates and DALYs. Both indirect and direct (medical and non-medical) costs of dementia care were computed.Results: The crude incidence rate was 16 (CI: 13–20) cases per 1,000 person-years (pyr) with 17 (CI: 12–21) per 1,000 pyr for females and 14 (CI: 9–21) per 1,000 pyr for males. Based on this incidence, we project an estimation of 220,632 new cases in 2030, 295,066 in 2040, and 378,461 in 2050. Disease burden was at 2,876 DALYsper 100,000 persons. The economic burden per patient was around Php 196,000 annually (i.e., ~4,070 USD, or 36.7% of average family annual income in the Philippines). The majority (86.29%) of this care expense was indirect cost attributed to estimated lost potential earning of unpaid family caregivers whereas direct medical cost accounted for only 13.48%.Conclusions: We provide the first Filipino community-based data on the incidence of dementia, DALYs, and cost of care to reflect the epidemiologic and economic impact of disease. The findings of this study serve to guide the development of a national dementia plan.

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Risk Factors for Incident Dementia Among Older Cubans

Cited by 8 publications

References 44 publications

Dementia Prevalence, Comorbidities, and Lifestyle Among Jatinangor Elders

Dementia Prevalence, Comorbidities, and Lifestyle Among Jatinangor Elders

Physical activity as a protective factor for dementia and Alzheimer’s disease: systematic review, meta-analysis and quality assessment of cohort and case–control studies

Dementia Incidence, Burden and Cost of Care: A Filipino Community-Based Study

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