2011
DOI: 10.3324/haematol.2011.054775
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Risk factors for in-hospital venous thromboembolism in children: a case-control study employing diagnostic validation

Abstract: BackgroundStudies evaluating risk factors for in-hospital venous thromboembolism in children are limited by quality assurance of case definition and/or lack of controlled comparison. The objective of this study is to determine risk factors for the development of in-hospital venous thromboembolism in children. Design and MethodsIn a case-control study at The Children's Hospital, Colorado, from 1 st January 2003 to 31 st December 2009 we employed diagnostic validation methods to determine pediatric in-hospital v… Show more

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Cited by 100 publications
(111 citation statements)
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“…1 The potential role of age in HA-VTE risk warrants further study. Previous work 1 has shown that neonates and adolescents are most commonly affected by HA-VTE; however, in some of the more recent case-control studies 2,18 age is used as a matching criterion and hence could not be assessed as a potential risk factor. Furthermore, HA-VTE case validation via radiological record review was not employed in a number of studies which suggested age is a risk factor in children.…”
Section: A B C Dmentioning
confidence: 99%
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“…1 The potential role of age in HA-VTE risk warrants further study. Previous work 1 has shown that neonates and adolescents are most commonly affected by HA-VTE; however, in some of the more recent case-control studies 2,18 age is used as a matching criterion and hence could not be assessed as a potential risk factor. Furthermore, HA-VTE case validation via radiological record review was not employed in a number of studies which suggested age is a risk factor in children.…”
Section: A B C Dmentioning
confidence: 99%
“…In addition, age was not found to be a risk factor in a meta-analysis. However, age, particularly adolescents and neonates, had been shown to be a risk factor in some individual case-control studies, 2,18 and as noted below, adolescents and neonates were the most common age groups represented in non-case-control studies. Lastly, we could not conduct any quantitative analyses for publication bias in risk factors among case-control studies because of the paucity of studies available for each risk factor.…”
Section: Risk Factors -Case-control Studiesmentioning
confidence: 99%
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“…Previous studies reporting the occurrence of VTE in the children have concentrated on the overall occurrence during hospitalisation and have not reported how the risk of VTE alters with time following hospitalisation with the majority of studies reporting in-patient data only [5][6][7]24]. A single centre retrospective study of hospital associated VTE reported that 18% of patients with an admission for VTE had undergone a general surgical or trauma related surgical procedure in the three months prior to admission with VTE [6].…”
Section: Other Literaturementioning
confidence: 99%