Risk Factors for Imported Fatal<i>Plasmodium falciparum</i>Malaria, France, 1996–2003

Legros, F.; Bouchaud, Olivier; Ancelle, T.; Arnaud, A; Cojean, Sandrine; Bras, J. Le; Danis, M.; Fontanet, Arnaud; Durand, Rémy; Epidemiology, Autochthonous Malaria

doi:10.3201/eid1306.060955

Cited by 92 publications

(42 citation statements)

References 28 publications

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“…ICU mortality (5.47 %) was close to previously reported rates [17, 21, 27, 28]. We found that adult mortality rates in MW and ambulatory care were 0.1 and 0.01 %.…”

Section: Discussionsupporting

confidence: 87%

Hospitalization and ambulatory care in imported-malaria: evaluation of trends and impact on mortality. A prospective multicentric 14-year observational study

Casalino

Etienne

Houzé

2016

Malar J

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BackgroundHospitalization is usually recommended for imported malaria. The goal of the present study is to evaluate the evolution in clinical pathways while measuring their impact on mortality.MethodsThis is a 14-year prospective observational study divided into three periods. We evaluated for adult (≥15 years) and paediatric (<15 years) case trends in severity, clinical pathways (hospitalization in medical ward (MW) or intensive care unit (ICU), ambulatory care) and mortality.ResultsIn total, 21,386 imported malaria cases were included, 4269 of them were paediatrics (20 %). Rises in severe forms for adults [from 8 % in period 1–14 % in period 3 (p = 0.0001)] and paediatrics [from 12 to 18 % (p < 0.0001)] were found. For adults, MW admission rates decreased [−15 % (CI 95 % −17; −13)] while ambulatory care [+7 % (CI 95 % 5–9)] and ICU admission rates [+4 % (CI 95 % 3–5)] increased. For paediatrics, increase in ICU admissions (+3 %) was shown. We did not observe any change in overall mortality during the study periods, whether among adults or children, regardless of care pathway.ConclusionsThe present study indicates a changing management of imported malaria in adults, with an increasing trend for ambulatory care. The absence of change in mortality for adults indicates that ambulatory care can be proposed for adults presenting non-severe imported malaria.Electronic supplementary materialThe online version of this article (doi:10.1186/s12936-016-1364-9) contains supplementary material, which is available to authorized users.

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“…ICU mortality (5.47 %) was close to previously reported rates [17, 21, 27, 28]. We found that adult mortality rates in MW and ambulatory care were 0.1 and 0.01 %.…”

Section: Discussionsupporting

confidence: 87%

Hospitalization and ambulatory care in imported-malaria: evaluation of trends and impact on mortality. A prospective multicentric 14-year observational study

Casalino

Etienne

Houzé

2016

Malar J

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“…Moreover, we found higher case fatality rates occurred in imported cases during January and February, which normally covers the Chinese New Year holidays. In this period, delayed presentation to medical services, lower levels of hospital staffing over the holiday period, and delays in communication of malaria diagnosis from laboratory to physician may be contributory factors, and other possibilities include initial misdiagnosis of a febrile illness as influenza-like illness in the winter-spring epidemic season728. Additionally, the fatal cases had a shorter median length of stay, which might relate to the severity of infection, healthcare-seeking behaviours, malaria prevention measures, individual immunity and the previous history of malaria, among other factors.…”

Section: Discussionmentioning

confidence: 99%

Plasmodium falciparum malaria importation from Africa to China and its mortality: an analysis of driving factors

Lai

Wardrop

Huang

et al. 2016

Sci Rep

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Plasmodium falciparum malaria importation from Africa to China is rising with increasing Chinese overseas investment and international travel. Identifying networks and drivers of this phenomenon as well as the contributors to high case-fatality rate is a growing public health concern to enable efficient response. From 2011–2015, 8653 P. falciparum cases leading to 98 deaths (11.3 per 1000 cases) were imported from 41 sub-Saharan countries into China, with most cases (91.3%) occurring in labour-related Chinese travellers. Four strongly connected groupings of origin African countries with destination Chinese provinces were identified, and the number of imported cases was significantly associated with the volume of air passengers to China (P = 0.006), parasite prevalence in Africa (P < 0.001), and the amount of official development assistance from China (P < 0.001) with investment in resource extraction having the strongest relationship with parasite importation. Risk factors for deaths from imported cases were related to the capacity of malaria diagnosis and diverse socioeconomic factors. The spatial heterogeneity uncovered, principal drivers explored, and risk factors for mortality found in the rising rates of P. falciparum malaria importation to China can serve to refine malaria elimination strategies and the management of cases, and high risk groups and regions should be targeted.

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“…Each year, 2, 200 imported malaria cases are reported to the French Malaria National Reference Center (FMNRC) among returned international travellers, and the real number of cases is estimated at 4, 000 [1]. Prompt diagnosis is essential for the treatment and outcome.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Clearview® malaria pLDH malaria rapid diagnostic test in a non-endemic setting

Houzé

Hubert

Cohen³

et al. 2011

Malar J

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BackgroundMalaria Rapid Diagnostic Tests (RDTs) are widely used to diagnose malaria. The present study evaluated a new RDT, the Clearview® Malaria pLDH test targeting the pan-Plasmodium antigen lactate dehydrogenase (pLDH).MethodsThe Clearview® Malaria pLDH test was evaluated on fresh samples obtained in returned international travellers using microscopy corrected by PCR as the reference method. Included samples were Plasmodium falciparum (139), Plasmodium vivax (22), Plasmodium ovale (20), Plasmodium malariae (7), and 102 negative.ResultsOverall sensitivity for the detection of Plasmodium spp was 93.2%. For P. falciparum, the sensitivity was 98.6%; for P. vivax, P. ovale and P. malariae, overall sensitivities were 90.9%, 60.0% and 85.7% respectively. For P. falciparum and for P. vivax, the sensitivities increased to 100% at parasite densities above 100/μl. The specificity was 100%. The test was easily to perform and the result was stable for at least 1 hour.ConclusionThe Clearview® Malaria pLDH was efficient for the diagnosis of malaria. The test was very sensitive for P. falciparum and P. vivax detection. The sensitivities for P. ovale and P. malariae were better than other RDTs

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Risk Factors for Imported FatalPlasmodium falciparumMalaria, France, 1996–2003

Cited by 92 publications

References 28 publications

Hospitalization and ambulatory care in imported-malaria: evaluation of trends and impact on mortality. A prospective multicentric 14-year observational study

Hospitalization and ambulatory care in imported-malaria: evaluation of trends and impact on mortality. A prospective multicentric 14-year observational study

Plasmodium falciparum malaria importation from Africa to China and its mortality: an analysis of driving factors

Evaluation of the Clearview® malaria pLDH malaria rapid diagnostic test in a non-endemic setting

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