Risk factors for Human Papillomavirus Exposure and Co-factors for Cervical Cancer in Latin America and the Caribbean

Almonte, Maribel; Albero, Ginesa; Molano, Mónica; Cárcamo, César; García, Patricia J.; Pérez, Gonzalo

doi:10.1016/j.vaccine.2008.06.008

Cited by 110 publications

(113 citation statements)

References 62 publications

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“…Among healthy women, an HPV infection was able to clear within 1-2 years (Klug et al, 2009;Schiffman et al, 2007) and <1% of HPV-positive women would go on to develop cervical cancer (Josefsson et al, 2000;Nagpal et al, 2002). The current report indicates that the involvement of other factors such as sexual behavior, personal and partner smoking habits and genetic backgrounds are likely co-factors with HPV for an increased risk of developing cervical cancer (Settheetham-Ishida et al, 2004;Settheetham-Ishida et al, 2005;Au et al, 2007;Almonte et al, 2008).…”

Section: Discussionmentioning

confidence: 62%

Risk Factors for Cervical Cancer in Northeastern Thailand: Detailed Analyses of Sexual and Smoking Behavior

Natphopsuk

Settheetham-Ishida²,

Sinawat³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Cervical cancer is a serious public health problem in Thailand. We investigated possible risk factors for cervical cancer including HPV infection, p53 polymorphism, smoking and reproductive history among women in Northeast Thailand using a case control study with 177 cases and age-matched controls. Among the HPV carriers, a significantly increased risk for cervical cancer with an OR of 36.97 (p<0.001) and an adjusted OR of 38.07 (p<0.001) were observed. Early age at first sexual exposure, and multiple sexual partners increased the risk of cervical cancer with ORs ranging between 1.73-2.78 (p<0.05). The interval between menarche and first sexual intercourse <6 years resulted in a significant increase in the risk for cervical cancer with ORs ranging between 3.32-4.09 and the respective adjusted OR range for the 4-5 and 2-3 year-old groups were 4.09 and 2.92. A higher risk was observed among subjects whose partner had smoking habits, whether currently or formerly; with respective ORs of 3.36 (p<0.001) and 2.17 (p<0.05); and respective adjusted ORs of 2.90 (p<0.05) and 3.55 (p<0.05). Other smoking characteristics of the partners including smoking duration ≥ 20 years, number of cigarettes smokes ≥ 20 pack-years and exposure time of the subject to passive smoking ≥ 5 hrs per day were found to be statistically significant risks for cervical cancer with adjusted ORs of 3.75, 4.04 and 11.8, respectively. Our data suggest that the risk of cervical cancer in Thai women is substantially associated with smoking characteristics of the partner(s), the interval between menarche and first sexual intercourse as well as some other aspects of sexual behavior.

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Section: Discussionmentioning

confidence: 62%

Risk Factors for Cervical Cancer in Northeastern Thailand: Detailed Analyses of Sexual and Smoking Behavior

Natphopsuk

Settheetham-Ishida²,

Sinawat³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…2 Infection by human papillomavirus (HPV) is the main cause of cervical intraepithelial neoplasia (CIN), which is a precursor lesion for cervical cancer. 3 In addition to HPV infection, the presence of cofactors such as young age at first sexual intercourse, large number of sexual partners and high-risk sexual behavior of the partner significantly increase the risk of CIN. 3 Longterm use of oral contraceptives, high parity and smoking are also established factors for the development of CIN and cervical cancer among HPV-infected women.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and risk factors for cervical intraepithelial neoplasia in HIV-infected women in Salvador, Bahia, Brazil

Oliveira

Travessa

et al. 2010

Sao Paulo Med. J.

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CONTEXT AND OBJECTIVE: The human immunodeficiency virus (HIV) is frequently associated with high-grade intraepithelial neoplasia.Immunosuppression and high HIV viral load are the main risk factors for cervical intraepithelial neoplasia (CIN). The aim of this study was to determine the prevalence of CIN in HIV-infected women in Salvador, Bahia, Brazil, and to describe the risk factors in comparison with non-infected women. RESULTS: CIN was more prevalent among HIV-infected women than in the control group (26.6% versus 6.6%; P = 0.01). The odds ratio for CIN among HIV-infected women was 3.7 (95% confidence interval, CI: 1.23-11; P = 0.01), after adjusting for the following variables: age at first sexual intercourse, number of partners, number of deliveries and previous history of sexually transmitted disease. CONCLUSION:The prevalence of CIN among HIV-infected women was significantly higher than among women without HIV infection. HIV infection was the most important risk factor associated with the development of cervical lesions.RESUMO CONTEXTO E OBJETIVO: O vírus da imunodeficiência humana (HIV) está frequentemente associado à neoplasia intraepitelial de alto grau.Imunossupressão e carga viral do HIV elevada são os principais fatores de risco para neoplasia intra-epitelial cervical (NIC). O objetivo deste estudo foi determinar a prevalência de NIC em mulheres infectadas pelo HIV, em Salvador, Bahia, Brasil e descrever os fatores de risco, comparando-as com mulheres não infectadas.

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“…infection among HTLV-infected and uninfected groups when women were stratified into age ranges (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35), 36-45, 46-55, and 56-65 years). Four positive cases of HPV infection (18.2%) were observed in HTLV-infected women with 46-55 years, whereas none was found in the control group at same age (p = 0.31) (data not shown).…”

Section: Ethical Considerationsmentioning

confidence: 99%

“…Human papillomavirus (HPV) is the etiologic agent of one of the most prevalent sexually transmitted diseases in the world and is also directly related to cervical cancer 17 , the third most common cancer in Brazil. The HPV types 16 and 18 are the most frequent types found in cervical squamous cell carcinoma, accounting for more than 70% of cases 18 .…”

Section: Introductionmentioning

confidence: 99%

Evidence of a higher prevalence of HPV infection in HTLV-1-infected women: a cross-sectional study

Lôpo

Oliveira

Santana

et al. 2012

Rev. Soc. Bras. Med. Trop.

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INTRODUCTION:HTLV-1 infection increases susceptibility to other infections. Few studies have addressed the co-infection between HPV and HTLV-1 and the immune response involved in this interaction. The aim of this study was to determine the prevalence of cervical HPV infection in HTLV-1-infected women and to establish the risk factors involved in this co-infection. METHODS: A cross-sectional study was carried out in Salvador, Brazil, between September 2005 and December 2008, involving 50 HTLV-1-infected women from the HTLV Reference Center and 40 uninfected patients from gynecological clinic, both at the Bahiana School of Medicine. HPV infection was assessed using hybrid capture. HTLV-1 proviral load was quantified using real-time polymerase chain reaction (PCR). RESULTS: The mean age of HTLV-1-infected women (38 ± 10 years) was similar to that of the control group (36 ± 13 years). The prevalence of HPV infection was 44% in the HTLV-1-infected group and 22.5% in uninfected women (p = 0.03). HTLV-1-infected women had lower mean age at onset of sexual life (17 ± 3 years versus 19 ± 3 years; p = 0.03) and greater number of lifetime partners compared with the control group (4 ± 3 versus 2 ± 1; p < 0.01). In the group of HTLV-1-infected patients, there was neither difference in HTLV-1 proviral load between HPV-infected women and the uninfected. CONCLUSIONS: The prevalence of HPV infection was higher in HTLV-1-infected women. Further studies should be performed to evaluate the progression of this co-infection.

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Risk factors for Human Papillomavirus Exposure and Co-factors for Cervical Cancer in Latin America and the Caribbean

Cited by 110 publications

References 62 publications

Risk Factors for Cervical Cancer in Northeastern Thailand: Detailed Analyses of Sexual and Smoking Behavior

Risk Factors for Cervical Cancer in Northeastern Thailand: Detailed Analyses of Sexual and Smoking Behavior

Prevalence and risk factors for cervical intraepithelial neoplasia in HIV-infected women in Salvador, Bahia, Brazil

Evidence of a higher prevalence of HPV infection in HTLV-1-infected women: a cross-sectional study

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