Risk factors for human hantavirus infection: Franco-Belgian collaborative case-control study during 1995-6 epidemic

Crowcroft, Natasha S.; Infuso, A; Ilèf, D.; Guenno, B. Le; Desenclos, J C; Loock, F van; Clément, Jan

doi:10.1136/bmj.318.7200.1737

Cited by 48 publications

(40 citation statements)

References 5 publications

(4 reference statements)

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“…(Email : BrockmannS@rki. de) or trapping rodents, entering potentially rodentinfested rooms, wood cutting, exposure in a forest and being a construction worker [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Survey and case-control study during epidemics of Puumala virus infection

et al. 2009

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SUMMARYIn Baden-Wuerttemberg, a federal state in south-west Germany, a large outbreak of 1089 laboratory-confirmed human Puumala virus (PUUV) infections occurred in 2007. We conducted a survey to describe the disease burden and a case-control study to identify risk factors for acquiring PUUV. Case-patients were interviewed about clinical outcome and both case-patients and randomly recruited controls were interviewed about exposure. We calculated matched odds ratios (mOR) using a conditional logistic regression model. Multivariable analysis of 191 matched case-control pairs showed that case-patients were more likely than controls to have seen small rodents/their droppings (mOR 1 . 9, 95 % CI 1 . 2-3 . 0), cleaned utility rooms (mOR 1 . 8, 95 % CI 1 . 0-3 . 4) and visited forest shelters (mOR 3 . 9, 95% CI 1 . 1-14 . 3). Two thirds of case-patients required hospitalization. During PUUV epidemics rodent control measures and use of protective equipment should be considered in utility rooms and shelters.

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“…(Email : BrockmannS@rki. de) or trapping rodents, entering potentially rodentinfested rooms, wood cutting, exposure in a forest and being a construction worker [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Survey and case-control study during epidemics of Puumala virus infection

et al. 2009

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“…Farmers are also at risk because of increased contact with rodents and their surroundings (4,30,37,38). Crowcroft et al (39) reported that Hantavirus infection was 6.1 times more frequent in people spending more than 16 h a day in forests (OR ＝ 1.9-19.5; P ＝ 0.03). The seropositivity of forest workers was significantly higher than the other patients in our study.…”

Section: Discussionmentioning

confidence: 99%

Serologic Investigation of Hantavirus Infection in Patients with Previous Thrombocytopenia, and Elevated Urea and Creatinine Levels in an Epidemic Region of Turkey

Sevencan

Gözalan²,

Uyar

et al. 2015

Jpn J Infect Dis

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SUMMARY:The first cases of Hantavirus infection in Turkey were reported in early 2009 in the Zonguldak and Bartin provinces. The aim of this study was to investigate the presence of Hantavirus antibodies in patients who had clinical and laboratory findings that were potentially associated with Hantavirus infection prior to the epidemic in Bartin in 2009. After screening 314,577 medical records from between 2007 and 2009, the clinical and laboratory data for 442 patients meeting the criteria of coexistent thrombocytopenia, and elevated urea and creatinine levels were transferred to a statistical program. Home visits were made to 170 patients, 84 of whom consented to participate in the study. The participants completed a questionnaire and provided a blood sample. Commercial anti-Hantavirus IgG and IgM ELISA and immunoblotting assays were used, with seropositive samples being confirmed by focus reduction neutralization tests (FRNT). ELISA and/or immunoblotting assays detected 10 positive samples; however, only 7 of these were recorded as positive by FRNT. FRNT positivity was significantly associated with female sex, the presence of a barn near to the house, and working in a forest (P ＜ 0.05). In a Hantavirus endemic region, physicians must keep in mind that thrombocytopenia, and elevated urea and creatinine levels may indicate Hantavirus infection.

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“…1-1 . 1) [6], but was esteemed in the Finnish study as 'non-significant ', rather than borderline significant with a P value of 0 . 06.…”

Section: Smoking and Other Risk Factors For Hantavirus Infections : Tmentioning

confidence: 99%

“…2) in another early Franco-Belgian case-control study, not mentioned in the Finnish study, probably because the P value was only 0 . 43 [6]. Interestingly, careful analysis of a recent so-called urban NE outbreak in 'metropolitan ' Cologne (Western Germany), teaches us that most patients lived, worked, or recreated near or in the semi-forested outer city park, significantly enough called 'Stadtwald ' (forest of the city) [7].…”

Section: Smoking and Other Risk Factors For Hantavirus Infections : Tmentioning

confidence: 99%