Risk factors for hospitalized respiratory syncytial virus disease and its severe outcomes

Cai, Wei; Buda, Silke; Schuler, Ekkehard; Hirve, Siddhivinayak; Zhang, Wenqing; Haas, Walter

doi:10.1111/irv.12729

Cited by 28 publications

(32 citation statements)

References 40 publications

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“…Risk factors for RSV associated ALRI include prematurity, low birth weight, underlying congenital heart disease, chronic lung disease, and parental smoking (9,10). In addition, upregulation of proinflammatory interleukins (IL)-8, and macrophage inflammatory protein (MIP)-1a accompanied by a strong neutrophil infiltration are associated with severe RSV induced manifestations, such as bronchiolitis (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Detection of respiratory syncytial virus defective genomes in nasal secretions is associated with distinct clinical outcomes

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Detection of respiratory syncytial virus defective genomes in nasal secretions is associated with distinct clinical outcomes

et al. 2021

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“…In 2015, the World Health Organization (WHO) indicated a high priority on establishing global RSV disease surveillance systems, as well as robust age-specific estimations in order to determine the optimal age for immunization [ 16 ]. However, data on the prevalence of RSV and the burden of disease in healthy children are scarce, as most studies are conducted only in high-risk groups [ 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Risk Factors of Respiratory Syncytial Virus in Children under 5 Years of Age in the WHO European Region: A Systematic Review and Meta-Analysis

Suleiman‐Martos

Caballero-Vázquez

Gómez‐Urquiza

et al. 2021

JPM

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A respiratory syncytial virus (RSV) is the major cause of respiratory tract infection in children under 5 years. However, RSV infection in the European Region of the World Health Organization has not been systematically reviewed. The aim was to determine the prevalence and factors associated with RSV in children under 5 years of age in European regions. A systematic review and meta-analysis was performed. CINAHL, Medline, LILACS, ProQuest, SciELO, and Scopus databases were consulted for studies published in the last 5 years, following Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. The search equation was “respiratory syncytial virus AND (newborn OR infant OR child) AND (prevalence OR risk factors)”. Studies reporting the prevalence of RSV were eligible for inclusion in the meta-analysis. A total of 20 articles were included. The meta-analytic prevalence estimation of RSV, with a sample of n = 16,115 children, was 46% (95% CI 34–59%). The main risk factors were age, male gender, winter season, and environmental factors such as cold temperatures, higher relative humidity, high concentrations of benzene, exposure to tobacco, and living in urban areas. Robust age-specific estimates of RSV infection in healthy children should be promoted in order to determine the optimal age for immunization. In addition, it is necessary to analyse in greater depth the potentially predictive factors of RSV infection, to be included in prevention strategies.

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“…These results are comparable to reviews of RSV CFRs for infants and children in high-income countries [ 10 , 55 ]. A German study of 8521 infants and children <5 years hospitalized with RSV reported an overall CFR of 0.12% [ 56 ]. However, this review also revealed that nationally representative estimates of RSV mortality for otherwise healthy, late preterm to full-term infants are limited and out of date (no available mortality rates; latest update through 2007 for mortality counts and update in 2013 for CFRs) or are not stratified by important demographic or clinical variables such as race or insurance payer.…”

Section: Discussionmentioning

confidence: 99%

Mortality Among US Infants and Children Under 5 Years of Age with Respiratory Syncytial Virus and Bronchiolitis: A Systematic Literature Review

Bylsma

Suh

Movva

et al. 2022

The Journal of Infectious Diseases

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Background A systematic literature review was conducted to summarize the mortality (overall and by disease severity factors) of US infants and children aged <5 years with respiratory syncytial virus (RSV) or all-cause bronchiolitis (ACB). Methods Comprehensive, systematic literature searches were conducted; articles were screened using prespecified eligibility criteria. A standard risk of bias tool was used to evaluate studies. Mortality was extracted as the rate per 100 000 or the case fatality ratio (CFR; proportion of deaths among RSV/ACB cases). Results Among 42 included studies, 36 evaluated inpatient deaths; 10 used nationally representative populations updated through 2013, and only 2 included late-preterm/full-term otherwise healthy infants and children. The RSV/ACB definition varied across studies (multiple International Classification of Diseases [ICD] codes; laboratory confirmation); no study reported systematic testing for RSV. No studies reported RSV mortality rates, while 3 studies provided ACB mortality rates (0.57–9.4 per 100 000). CFRs ranged from 0% to 1.7% for RSV (n = 15) and from 0% to 0.17% for ACB (n = 6); higher CFRs were reported among premature, intensive care unit-admitted, and publicly insured infants and children. Conclusions RSV mortality reported among US infants and children is variable. Current, nationally representative estimates are needed for otherwise healthy, late-preterm to full-term infants and children.

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Risk factors for hospitalized respiratory syncytial virus disease and its severe outcomes

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 28 publications

References 40 publications

Detection of respiratory syncytial virus defective genomes in nasal secretions is associated with distinct clinical outcomes

Detection of respiratory syncytial virus defective genomes in nasal secretions is associated with distinct clinical outcomes

Prevalence and Risk Factors of Respiratory Syncytial Virus in Children under 5 Years of Age in the WHO European Region: A Systematic Review and Meta-Analysis

Mortality Among US Infants and Children Under 5 Years of Age with Respiratory Syncytial Virus and Bronchiolitis: A Systematic Literature Review

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