Risk Factors for High-Grade Heterotopic Ossification After Total Disc Replacement: A Single-Center Experience of 394 Cases

Wang, Han; Wang, Xiaofei; Líu, Hao; Meng, Yang; Guo, Yingjun; Hong, Ying

doi:10.1093/neuros/nyab298

Cited by 12 publications

(7 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, we conducted subgroup analyses and meta-regression for these parameters. Furthermore, a high degree of ossification before surgery, 34 insufficient endplate coverage of the prosthesis, 35 – 37 intervertebral space height change before and after surgery ≥1.8 mm, 35 excessive intervertebral space distraction, 38 and disk space angle change during operation >5° 39 may lead to higher incidences of HO. The above patient characteristics and surgical details may vary between studies.…”

Section: Discussionmentioning

confidence: 99%

Incidence of Heterotopic Ossification at 10 years after Cervical Disc Replacement

Sheng

Líu

et al. 2023

Spine

Self Cite

View full text Add to dashboard Cite

Study Design. Systematic review and meta-analysis. Objective. This study aimed to assess the incidence of heterotopic ossification (HO) 10 years after cervical disk replacement (CDR). Summary of Background Data. HO is a common complication after CDR and may limit the range of motion of the artificial disk. As HO usually progresses slowly, a long-term follow-up is required to better understand its incidence. In recent years, the increasing number of original articles reporting 10-year outcomes gives us the opportunity to better understand the long-term incidence of HO. Materials and Methods. We searched PubMed, Medline, Embase, and Cochrane Library databases to identify eligible studies. The incidence of HO was pooled, and subgroup analysis was performed. Meta-regression analyses were conducted to identify factors contributing to heterogeneity. Results. Eleven studies with at least 10 years of follow-up comprising 1140 patients who underwent CDR were included. The pooled incidence of overall HO was 70% (95% CI, 60%–81%) at 10 years postoperatively, 60% (95% CI, 44%–75%) at five or six years postoperatively, and 50% (95% CI, 27%–72%) at one or two years postoperatively. The pooled incidence of severe HO (grade 3 or 4) was 37% (95% CI, 29%–45%), and mild HO (grade 1 to 2) was 30% (95% CI, 17%–44%) at 10 years of follow-up. Pooled range of motion decreased from 8.59° before surgery to 7.40° 10 years after surgery. Subgroup analysis showed that HO incidence differed according to the prosthesis type. The earlier publication was associated with a higher pooled incidence of severe HO in the meta-regression analysis. Conclusions. This is the first meta-analysis providing detailed information on the pooled 10-year incidence of HO after CDR. The incidence of HO seems to increase with the length of follow-up. Level of Evidence. 3.

show abstract

Section: Discussionmentioning

confidence: 99%

Incidence of Heterotopic Ossification at 10 years after Cervical Disc Replacement

Sheng

Líu

et al. 2023

Spine

Self Cite

View full text Add to dashboard Cite

show abstract

“…This indicates that “cervical disc replacement” is a focus of researchers’ attention and a current hot topic in TDR research. In addition, more and more researchers are concerned about the long-term prognosis and complications such as heterotopic ossification [34,35] after TDR.…”

Section: Discussionmentioning

confidence: 99%

Global trends and frontiers of research on total disc replacement: A bibliometric analysis

Li,

Tian,

et al. 2023

Medicine

View full text Add to dashboard Cite

With the increased risk of complications associated with traditional spinal fusion for the treatment of degenerative disc disease, total disc replacement (TDR) has received increasing attention in recent years. Despite the rapid development of its related research fields, its research status and the hotspot analysis are still unclear. Our goal was to identify and analyze the global research trends on TDR using bibliometric tools. All TDR data were obtained from the WoSCC. The information of research field was collected, including title, author, institutions, journals, countries, references, total citations, and years of publication for further analysis. From 1993 to 2022, a total of 1167 articles and 11,348 references were included in this field. These publications are mainly from 53 countries/regions and 174 journals, led by the United States and China. According to the citation report, the US was absolutely in the leading position in this research field. The most contribution institution and author were Sichuan University and Liu H. Spine and European Spine Journal were the most active journal on TDR research, with 205 and 118 articles. Meanwhile, they were also the most frequently cited journals. The “bone loss,” “cervical arthroplasty,” “hybrid surgery” were the most frequently cited areas of TDR research. Meanwhile, the latest research hotspots and directions were “cervical disc arthroplasty,” “7 year follow up,” “heterotopic ossification.” The scientific research on TDR has increased considerably in recent years. This study clarifies the current research status and future development trends in order to guide clinicians and researchers in the field of TDR. It can be inferred that cervical disc arthroplasty and bone loss will be the research focus in the future.

show abstract

“…However, cervical disc arthroplasty (CDA) is not a suitable substitute for ACCF due to different indications. Furthermore, this procedure potentially causes an abnormal excessive postoperative motion, which can compromise the stability of the cervical spine and may lead to heterotopic ossification (HO), posing a risk of a decrease in range of motion (ROM) at the index level ( Wang et al, 2021 ). Approximately 32.5% of the post-CDA patients experienced HO, and 11.0% developed ROM-limited HO, which may eventually progress to secondary fusion ( Hui et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Does the novel artificial cervical joint complex resolve the conflict between stability and mobility after anterior cervical surgery? a finite element study

Meng,

Zhao,

Wang

et al. 2024

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Background and objectiveOur group has developed a novel artificial cervical joint complex (ACJC) as a motion preservation instrument for cervical corpectomy procedures. Through finite element analysis (FEA), this study aims to assess this prosthesis’s mobility and stability in the context of physiological reconstruction of the cervical spine.Materials and methodsA finite element (FE)model of the subaxial cervical spine (C3-C7) was established and validated. ACJC arthroplasty, anterior cervical corpectomy and fusion (ACCF), and two-level cervical disc arthroplasty (CDA) were performed at C4-C6. Range of motion (ROM), intervertebral disc pressure (IDP), facet joint stress (FJS), and maximum von Mises stress on the prosthesis and vertebrae during loading were compared.ResultsCompared to the intact model, the ROM in all three surgical groups demonstrated a decline, with the ACCF group exhibiting the most significant mobility loss, and the highest compensatory motion in adjacent segments. ACJC and artificial cervical disc prosthesis (ACDP) well-preserved cervical mobility. In the ACCF model, IDP and FJS in adjacent segments increased notably, whereas the index segments experienced the most significant FJS elevation in the CDA model. The ROM, IDP, and FJS in both index and adjacent segments of the ACJC model were intermediate between the other two. Stress distribution of ACCF instruments and ACJC prosthesis during the loading process was more dispersed, resulting in less impact on the adjacent vertebrae than in the CDA model.ConclusionThe biomechanical properties of the novel ACJC were comparable to the ACCF in constructing postoperative stability and equally preserved physiological mobility of the cervical spine as CDA without much impact on adjacent segments and facet joints. Thus, the novel ACJC effectively balanced postoperative stability with cervical motion preservation.

show abstract

Risk Factors for High-Grade Heterotopic Ossification After Total Disc Replacement: A Single-Center Experience of 394 Cases

Cited by 12 publications

References 40 publications

Incidence of Heterotopic Ossification at 10 years after Cervical Disc Replacement

Incidence of Heterotopic Ossification at 10 years after Cervical Disc Replacement

Global trends and frontiers of research on total disc replacement: A bibliometric analysis

Does the novel artificial cervical joint complex resolve the conflict between stability and mobility after anterior cervical surgery? a finite element study

Contact Info

Product

Resources

About