Risk factors for healthcare-associated infection caused by carbapenem-resistant Pseudomonas aeruginosa

Tsao, Li Hsin; Hsin, Chih Yi; Liu, Hsin Yi; Chuang, Han-Chuan; Chen, Li Yuan; Lee, Yuarn Jang

doi:10.1016/j.jmii.2017.08.015

Cited by 50 publications

(37 citation statements)

References 27 publications

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“…In accordance with previous prospective or retrospective studies, our results confirmed that prior exposure to carbapenems was an independent risk factor for CRPA infection or colonization [7][8][9]. However, in contrast with some other studies [13,16], we did not find that the use of fluoroquinolones, or aminoglycosides was associated with increased CRPA infection or colonization.…”

Section: Discussionsupporting

confidence: 89%

“…Identifying risk factors for the development of CRPA acquisition is important for treatment options, and consequently, a number of risk factors for CRPA infection or colonization have been revealed in some retrospective clinical studies [7][8][9][10][11][12][13][14]. However, the conclusions were not always consistent among these studies.…”

Section: Introductionmentioning

confidence: 99%

“…However, the conclusions were not always consistent among these studies. Antibiotic exposure was considered an independent factor for CRPA infection or colonization in some studies, especially carbapenem use [7][8][9], but not in all. Other independent factors were prior ICU stay [10], increased length of hospital stay [11][12][13], and urinary catheter insertion [14].…”

Section: Introductionmentioning

confidence: 99%

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Risk factors for carbapenem-resistant Pseudomonas aeruginosa infection or colonization in a Chinese teaching hospital

Zhang¹,

Cui

Wang

et al. 2018

J Infect Dev Ctries

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Introduction: Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is rapidly emerging as a life-threatening nosocomial infection. In this study, we aimed to identify risk factors, especially antibiotic use and co-carriage with other bacteria for CRPA infection or colonization. Methodology: A retrospective study was conducted in the First Affiliated Hospital of Xi’an Jiaotong University, which involved a cohort of patients with Pseudomonas aeruginosa infection or colonization from January 2014 to June 2016. Univariate analysis and multivariate analysis were performed to estimate the risk factors of CRPA occurrence. Results: Eight hundred and eighty-eight patients were included in the study. More than 50% of the risk factors were associated with CRPA infection or colonization according to univariate analysis (P < 0.05), such as invasive procedures, co-carriage with Gram-negative pathogens, and prior treatment with some antibiotics. However, only prior exposure to carbapenems (OR: 8.005; CI:4.507-14.217, P<0.001), the days of carbapenems treatment (OR: 1.190; CI: 1.073-1.272; P < 0.001), and co-carriage with Escherichia coli (OR: 1.824; CI: 1.005-3.310, P = 0.048) were considered independent risk factors by multivariate analysis. A higher mortality was found among patients with CRPA infection or colonization (P < 0.05). Conclusions: Risk factors for CRPA infection or colonization were prior exposure to carbapenems, the days of carbapenems treatment, and co-carriage with Escherichia coli. The prevalence of CRPA could be influenced by Gram-negative pathogens, especially in Escherichia coli, and it need more researches. Moreover, restrictions in the clinical use of carbapenems should be taken into account.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Risk factors for carbapenem-resistant Pseudomonas aeruginosa infection or colonization in a Chinese teaching hospital

Zhang¹,

Cui

Wang

et al. 2018

J Infect Dev Ctries

View full text Add to dashboard Cite

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“…This could also lead to the production of odor and slime in food products. Reusing the ingredients stored at room temperature for few hours pose risk to consumers especially if they are immune compromised (Tsao et al, 2018). Apart from being a spoilage microorganism, Pseudomonas spp.…”

Section: Introductionmentioning

confidence: 99%

Incidance of Psychotropic bacteria in frozen chicken meat products with special reference to Pseudomonas species

Sheir

Ibrahim

Hassan

et al. 2020

Benha Veterinary Medical Journal

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Total of hundred random samples of frozen chicken products represented by breast, thigh, nuggets and burger (25 of each) were collected from various supermarkets located in Menoufia government. To study the incidence of psychotropic bacteria with special reference to Pseudomonas species. The study revealed that mean values of Psychotropic count were 8.17×10 3 ± 1.42×10 3 , 1.95×10 4 ± 2.06×10 4 , 3.63×10 4 ± 0.89×10 4 and 7.58×10 4 ± 1.16×10 4 respectively while the mean value of Pseudomonas counts were 3.51×10 3 ± 0.76×10 3 , 6.29×10 3 ± 1.12×10 3 ,8.44×10 3 ± 1.85×10 3 , 1.71×10 4 ± 0.36×10 4 respectively for examined frozen breast, thigh, nuggets and burger. It was obvious that 166 isolates were identified as P.

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“…This could also lead to the production of odour and slime in food products. Reusing the ingredients stored at room temperature for few hours pose risk to consumers especially if they are immunocompromised [7]. Apart from being a spoilage microorganism, Pseudomonas spp.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of spoilage microorganism, Pseudomonas spp. on restaurants cutting boards collected in Seri Kembangan, Malaysia.

Na¹,

Osman²,

S³

et al. 2019

J Nutr Food Sci

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Some of the enzymes produced by Pseudomonas are heat Due to the tropical climate that promotes the growth of most microorganisms, the food service industry in Malaysia faces a lot of challenges in order to ensure quality foods are served to the customers. One of the bacteria that are associated with food spoilage is Pseudomonas spp., and the presence of these bacteria on cutting boards could cross-contaminate food items during food handling. This study performed pyrosequencing analysis to investigate the existence of microbial communities on cutting boards collected from restaurants in Seri Kembangan, Malaysia. Most of the samples were dominated by Flavobacteriales, Enterobacteriales, Lactobacillales, and Pseudomonadales. This study discovered that, all samples of cutting boards were contaminated with Pseudomonas spp. With the mean bacterial count of 1.4 × 10 6 cfu/cm 2 , 5.1 × 10 5 cfu/cm 2 and 5.6 × 10 6 cfu/cm 2 on samples collected from clean, moderately clean and less clean food premises, respectively. The study shows that the contamination level of Pseudomonas spp. was not significantly different in different grades of food premises. Regardless of the status and grades of the food premises, they have the same likelihood to introduce spoilage bacteria like Pseudomonas spp. from cutting board to food if they neglect correct food handling measures. Therefore, all food handlers need to prioritize safe food handling to avoid food contamination and spoilage. Abstract

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Risk factors for healthcare-associated infection caused by carbapenem-resistant Pseudomonas aeruginosa

Cited by 50 publications

References 27 publications

Risk factors for carbapenem-resistant Pseudomonas aeruginosa infection or colonization in a Chinese teaching hospital

Risk factors for carbapenem-resistant Pseudomonas aeruginosa infection or colonization in a Chinese teaching hospital

Incidance of Psychotropic bacteria in frozen chicken meat products with special reference to Pseudomonas species

Prevalence of spoilage microorganism, Pseudomonas spp. on restaurants cutting boards collected in Seri Kembangan, Malaysia.

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