Risk Factors For Gestational Diabetes – An Update

Dobjanschi, Carmen; Miulescu, Rucsandra Dănciulescu

doi:10.1515/rjdnmd-2015-0025

Cited by 4 publications

(3 citation statements)

References 34 publications

(13 reference statements)

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“…To date, several risk factors have been identified for GDM such as family history of GDM or T2DM, previous stillbirth, maternal age over 30-35 years, obesity, insulin resistance, maternal metabolic syndrome, ethnicity, socioeconomic status, vitamin D deficiency, and polycystic ovary disease. 14,15 It is well documented that mothers with GDM are at higher risk of gestational hypertension, cesarean delivery, and preeclampsia. 16,17 GDM is thought to occur as a result of an autoimmune process, a condition of persistent insulin resistance, or a genetic predisposition to abnormal insulin secretion.…”

Section: Introductionmentioning

confidence: 99%

Enlightening the Correlation of Polymorphisms at FTO, LEP and LEPR Genes with Gestational Diabetes Mellitus Risk: a Meta-analysis

Golshan-Tafti,

Aarafi,

Hajizadeh

et al. 2023

WJPN

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Background: The adverse outcomes correlated with GDM for both the mother and the offspring are diverse. The link between polymorphisms at fat mass and obesity‐correlated protein (FTO), leptin (LEP), and leptin receptor (LEPR) genes and GDM is ambiguous. In this meta-analysis, we sought to investigate the correlation of FTO, LEP, and LEPR polymorphisms with GDM risk. Methods: We performed an online search on PubMed, Web of Science, and Google Scholar databases to identify all relevant research. Results: A total of 18 case-control studies including seven research with 893 cases and 2875 controls on FTO rs9939609, four research with 1345 cases and 1116 controls on FTO rs8050136, two research with 207 cases and 205 controls on FTO rs1421085, three studies with 529 cases and 581 controls on LEP rs7799039, and two research with 480 cases and 477 controls on LPER rs1137101 met our criteria. Combined data illustrated that the FTO rs9939609 and rs8050136 were correlated with a substantial risk of GDM in the overall population, but not FTO rs1421085. Furthermore, LEP rs2167270 and rs7799039 polymorphisms were not correlated with GDM risk. Sorted analyses illustrated that the FTO rs9939609 polymorphism was correlated with GDM in Caucasian women. Conclusion: This meta-analysis results illustrated that the FTO rs9939609 and rs8050136 were correlated with a substantial risk of GDM, but not FTO rs1421085, LEP rs7799039, and LPER rs1137101. Larger and more rigorous studies among different ethnicities are needed to further evaluate the correlations with GDM.

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Section: Introductionmentioning

confidence: 99%

Enlightening the Correlation of Polymorphisms at FTO, LEP and LEPR Genes with Gestational Diabetes Mellitus Risk: a Meta-analysis

Golshan-Tafti,

Aarafi,

Hajizadeh

et al. 2023

WJPN

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“…Various studies conducted highlighted that advanced maternal age was mostly associated with an increased likelihood of developing GDM. Women above age of 30 years are at increased risk of GDM [12,13]. Although GDM can be asymptomatic, it is associated with increased risk of complications associated with pregnancy and childbirth.…”

Section: Introductionmentioning

confidence: 99%

Factors Associated With Gestational Diabetes Mellitus in Rural Areas of Limpopo Province: A Descriptive Analysis

Ntshauba

Maimela

Ntuli

2020

Preprint

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Background: Sustainable Developmental Goal (SDG) no 3 of the United Nations Organisation places emphasise on ensuring healthy lives and promoting the well-being of all people of all age groups. Yet the prevalence of Gestational Diabetes Mellitus (GDM) is increasing and this can have an adverse impact on maternal and infant health and well-being. Currently, more studies have been conducted in International countries on prevalence and risk factors of GDM and few in South African Context. The current study sought to investigate the prevalence, risk factors, maternal and infant outcomes of women with gestational diabetes mellitus in Mopani District. Methods: A cross-sectional descriptive study was conducted amongst pregnant women during Antenatal Care Clinic Visits at Nkhensani Hospital, Nkhensani Gateway clinic and Giyani Healthcare Centre. Information from participants was collected using adapted questionnaire from Michigan Diabetes Research and Training Centre DCP 2.0 and data entry form, captured on Microsoft excel spread sheet and analysed using Statistical Package for Social Sciences (SPSS) and p-value of <0.05 was considered statistically significant.Results: One hundred and one (101) pregnant women (74%) who were attending antenatal care clinic visits at Nkhensani Hospital, Nkhensani Gateway Clinic and Giyani Healthcare Centre completed the questionnaire. Prevalence of Gestational Diabetes Mellitus (GDM) in Mopani District was 1.9% (2 women). Pregnant women above 30 years with secondary education, employed, obese and at gestational age of 31-35 weeks were more likely to present with GDM. A family history of diabetes was significantly associated with development of GDM. Conclusions: The use of various GDM screening strategies across population and countries resulted in discrepancies in the prevalence rate. Universal GDM screening strategy which will benefit our socioeconomic and clinical context to ensure that the true burden of GDM is determined needs to be adopted.

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“…Dietary behaviours, such as high intake of sugarsweetened beverages, fried foods and animal fat before or/and during pregnancy, had been linked to GDM (18)(19)(20) . A high amount of sugar had been directly linked to impaired pancreatic beta cell function in humans (21) .…”

mentioning

confidence: 99%

The association of the glucokinase rs4607517 polymorphism with gestational diabetes mellitus and its interaction with sweets consumption in Chinese women

Zhao

Song

et al. 2020

Public Health Nutr.

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Objective: To identify the association of the glucokinase gene (GCK) rs4607517 polymorphism with gestational diabetes mellitus (GDM) and determine whether sweets consumption could interact with the polymorphism on GDM in Chinese women. Design: We conducted a case–control study at a hospital including 1015 participants (562 GDM cases and 453 controls). We collected the data of pre-pregnancy BMI, sweets consumption and performed genotyping of the GCK rs4607517 polymorphism. Logistic regression was performed to test the association between the rs4607517 polymorphism and GDM, and the stratified analyses by sweets consumption were conducted, using an additive genetic model. Setting: A case–control study of women at a hospital in Beijing, China. Participants One thousand and fifteen Chinese women. Results: The GCK rs4607517 A allele was significantly associated with GDM (OR 1·35, 95 % CI 1·03, 1·77; P = 0·028). Furthermore, stratified analyses showed that the A allele increased the risk of GDM only in women who had a habitual consumption of sweet foods (sweets consumption ≥ once per week) (OR 1·61, 95 % CI 1·17, 2·21; P = 0·003). Significant interaction on GDM was found between the rs4607517 A allele and sweets consumption (P = 0·004). Conclusions: This study for the first time reported the interaction between the GCK rs4607517 polymorphism and sweets consumption on GDM. The results provided novel evidence for risk assessment and personalised prevention of GDM.

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Risk Factors For Gestational Diabetes – An Update

Cited by 4 publications

References 34 publications

Enlightening the Correlation of Polymorphisms at FTO, LEP and LEPR Genes with Gestational Diabetes Mellitus Risk: a Meta-analysis

Enlightening the Correlation of Polymorphisms at FTO, LEP and LEPR Genes with Gestational Diabetes Mellitus Risk: a Meta-analysis

Factors Associated With Gestational Diabetes Mellitus in Rural Areas of Limpopo Province: A Descriptive Analysis

The association of the glucokinase rs4607517 polymorphism with gestational diabetes mellitus and its interaction with sweets consumption in Chinese women

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