Risk Factors for Functional Decline and Impaired Quality of Life after Pediatric Respiratory Failure

Watson, R. Scott; Asaro, Lisa A.; Hutchins, Larissa; Bysani, G. Kris; Killien, Elizabeth Y; Angus, Derek C.; Wypij, David; Curley, Martha A. Q.

doi:10.1164/rccm.201810-1881oc

Cited by 65 publications

(105 citation statements)

References 29 publications

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“…The present study showed that parents appear to assess these outcomes accurately in their child. Recent publications in short-term outcomes already reported these impairments in growth and development 6 months after critical illness [7,19].…”

Section: Hrqol Of Critically Ill Children Versus Healthy Control Chilmentioning

confidence: 99%

Health-related quality of life of children and their parents 2 years after critical illness: pre-planned follow-up of the PEPaNIC international, randomized, controlled trial

Hordijk

Verbruggen

Vanhorebeek³

et al. 2020

Crit Care

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Background: Pediatric intensive care unit (PICU) survivors are at risk for prolonged morbidities interfering with daily life. The current study examined parent-reported health-related quality of life (HRQoL) in former critically ill children and parents themselves and aimed to determine whether withholding parenteral nutrition (PN) in the first week of critical illness affected children's and parents' HRQoL 2 years later. Methods: Children who participated in the pediatric early versus late parenteral nutrition in critical illness (PEPaNIC) trial and who were testable 2 years later (n = 1158) were included. Their HRQoL outcomes were compared with 405 matched healthy controls. At PICU admission, children had been randomly assigned to early-PN or late-PN. In the early-PN group, PN was initiated within 24 h after PICU admission. In the late-PN group, PN was withheld for up to 1 week in the PICU. Parents completed the Infant Toddler Quality of Life Questionnaire (ITQOL; age 2-3 years) or the Child Health Questionnaire-Parent Form 50 (CHQ-PF50; age 4-18 years). Besides, they completed the Health Utility Index (HUI) and the Short Form Health Survey (SF-12) regarding their child's and their own HRQoL, respectively. Results: For the total age group of 786 post-PICU survivors, parents reported lower scores for almost all HRQoL scales compared to healthy children. Age-specifically, younger critically ill children (2.5 to 3 years old) scored worse for growth and development and older children (4-18 years old) scored worse for role functioning and mental health. Parents' own mental and physical HRQoL was comparable to that of healthy control parents. No HRQoL differences were found between children in the late-PN and those in the early-PN group. Conclusions: Parent-reported HRQoL of children 2 years after critical illness was impaired compared with healthy controls. In relation to their child's HRQoL, parents reported impairments in emotions, personal time, and family activities; however, their own HRQoL was not impaired. Withholding PN in the first week during critical illness had no impact on longer-term HRQoL of the child.

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Section: Hrqol Of Critically Ill Children Versus Healthy Control Chilmentioning

confidence: 99%

Health-related quality of life of children and their parents 2 years after critical illness: pre-planned follow-up of the PEPaNIC international, randomized, controlled trial

Hordijk

Verbruggen

Vanhorebeek³

et al. 2020

Crit Care

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“…In a study presented in this issue of the Journal , Watson and colleagues (pp. 900–909) evaluated risk factors for a post-PICU decline in functioning and reduced HRQL in children with respiratory failure (5). Children 2 weeks to 17 years of age who were enrolled in the RESTORE (Randomized Evaluation of Sedation Titration for Respiratory Failure) trial were included in the study.…”

mentioning

confidence: 99%

“…Age-appropriate, validated measures of HRQL and functional abilities were assessed at 6 months after PICU discharge via medical record reviews of baseline functioning and parental interviews, and postdischarge functional status and HRQL were assessed by telephone interviews. The parents/guardians of 960 patients were interviewed, and 91% of these patients were discharged home and 6% were discharged to a rehabilitation or assisted-living facility (5).…”

mentioning

confidence: 99%

“…Among patients with normal baseline functioning, 49% had functional decline and 19% had reduced HRQL. Risk factors included sociodemographic factors, preexisting health status, and factors associated with the critical illness factors that occurred during the child’s hospital course ( see Table 1 for a summary) (5). The authors found that the magnitude of the new morbidities was similar to that observed in severe underlying diseases such as cancer (5).…”

mentioning

confidence: 99%

“…Risk factors included sociodemographic factors, preexisting health status, and factors associated with the critical illness factors that occurred during the child’s hospital course ( see Table 1 for a summary) (5). The authors found that the magnitude of the new morbidities was similar to that observed in severe underlying diseases such as cancer (5). Similar to findings in adults (6), the trajectories of outcomes were variable and included a continued decline over time, improvement over time, no change over time, and decline and then improvement.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Life after Pediatric Critical Illness: Risk Factors for Reduced Health-related Quality of Life and Functional Decline

Hopkins¹

2019

Am J Respir Crit Care Med

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Association of Acute Respiratory Failure in Early Childhood With Long-term Neurocognitive Outcomes

Watson

Beers

Asaro

et al. 2022

JAMA

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Key PointsQuestionDo children with previously normal neurocognitive function who survive an episode of acute respiratory failure requiring intensive care and invasive mechanical ventilation have worse long-term neurocognitive function than their matched siblings?FindingsIn this cohort study that included 121 sibling pairs, children discharged from intensive care hospitalization for respiratory failure without severe cognitive dysfunction compared with their matched siblings had a mean IQ score of 101.5 vs 104.3, a difference that was statistically significant.MeaningAcute respiratory failure in early childhood was associated with a slightly, but statistically significant, lower subsequent IQ score.

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Risk Factors for Functional Decline and Impaired Quality of Life after Pediatric Respiratory Failure

Cited by 65 publications

References 29 publications

Health-related quality of life of children and their parents 2 years after critical illness: pre-planned follow-up of the PEPaNIC international, randomized, controlled trial

Health-related quality of life of children and their parents 2 years after critical illness: pre-planned follow-up of the PEPaNIC international, randomized, controlled trial

Life after Pediatric Critical Illness: Risk Factors for Reduced Health-related Quality of Life and Functional Decline

Association of Acute Respiratory Failure in Early Childhood With Long-term Neurocognitive Outcomes

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