Risk factors for fracture in elderly men: a population-based prospective study

Frost, Morten; Abrahamsen, Bo; Masud, Tahir; Brixen, Kim

doi:10.1007/s00198-011-1575-4

Cited by 24 publications

(18 citation statements)

References 32 publications

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“…For the elderly, the most powerful risk factor of fracture is age [34]. In our study, the previous 5 months of each patient became the control group, and the age distribution of the patient group and control group is identical.…”

Section: Discussionmentioning

confidence: 94%

Zolpidem Use and Risk of Fracture in Elderly Insomnia Patients

Kang

Park

Rhee

et al. 2012

J Prev Med Public Health

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ObjectivesTo evaluate the risk of fractures related with zolpidem in elderly insomnia patients.MethodsHealth claims data on the entire South Korean elderly population from January 2005 to June 2006 were extracted from the Health Insurance Review and Assessment Service database. We applied a case-crossover design. Cases were defined as insomnia patients who had a fracture diagnosis. We set the hazard period of 1 day length prior to the fracture date and four control periods of the same length at 5, 10, 15, and 20 weeks prior to the fracture date. Time independent confounding factors such as age, gender, lifestyle, cognitive function level, mobility, socioeconomic status, residential environment, and comorbidity could be controlled using the casecrossover design. Time dependent confounding factors, especially co-medication of patients during the study period, were adjusted by conditional logistic regression analysis. The odds ratios and their 95% confidence intervals (CIs) were estimated for the risk of fracture related to zolpidem.ResultsOne thousand five hundred and eight cases of fracture were detected in insomnia patients during the study period. In our data, the use of zolpidem increased the risk of fracture significantly (adjusted odds ratio [aOR], 1.72; 95% CI, 1.37 to 2.16). However, the association between benzodiazepine hypnotics and the risk of fracture was not statistically significant (aOR, 1.00; 95% CI, 0.83 to 1.21). Likewise, the results were not statistically significant in stratified analysis with each benzodiazepine generic subgroup.ConclusionsZolpidem could increase the risk of fracture in elderly insomnia patients. Therefore zolpidem should be prescribed carefully and the elderly should be provided with sufficient patient education.

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Section: Discussionmentioning

confidence: 94%

Zolpidem Use and Risk of Fracture in Elderly Insomnia Patients

Kang

Park

Rhee

et al. 2012

J Prev Med Public Health

View full text Add to dashboard Cite

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“…This study identified predictive factors for osteoporotic fractures in elderly men that were not collected in our study, including quadriceps strength and sway factor (a measure of postural stability). Another known risk factor for fractures missing from our dataset was family history of fractures .…”

Section: Discussionmentioning

confidence: 99%

Impact of androgen suppression and zoledronic acid on bone mineral density and fractures in the Trans‐Tasman Radiation Oncology Group (TROG) 03.04 Randomised Androgen Deprivation and Radiotherapy (RADAR) randomized controlled trial for locally advanced prostate cancer

et al. 2014

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Objective• To study the influence of adjuvant androgen suppression and bisphosphonates on incident vertebral and non-spinal fracture rates and bone mineral density (BMD) in men with locally advanced prostate cancer. Patients and Methods• Between 2003 and 2007, 1071 men with locally advanced prostate cancer were randomly allocated, using a 2 × 2 trial design, to 6 months i.m. leuprorelin (androgen suppression [AS]) before radiotherapy alone ± 12 months additional leuprorelin ± 18 months zoledronic acid (ZdA), commencing at randomization. • The main endpoint was incident thoraco-lumbar vertebral fractures, which were assessed radiographically at randomization and at 3 years, then reassessed by centralized review.• Subsidiary endpoints included incident non-spinal fractures, which were documented throughout follow-up, and BMD, which was measured in 222 subjects at baseline, 2 years and 4 years. Results• Incident vertebral fractures at 3 years were observed in 132 subjects. Their occurrence was not increased by 18 months' AS, nor reduced by ZdA.• Incident non-spinal fractures occurred in 72 subjects and were significantly related to AS duration but not to ZdA.• Osteopenia and osteoporosis prevalence rates at baseline were 23.4 and 1.4%, respectively, at the hip. • Treatment for 6 and 18 months with AS caused significant reductions in hip BMD at 2 and 4 years (P < 0.01) and ZdA prevented these losses at both time points. Conclusion• In an AS-naïve population, 18 months of ZdA treatment prevented the sustained BMD losses caused by 18 months of AS treatment; however, the study power was insufficient to show that AS duration or ZdA influenced vertebral fracture rates.

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“…40 This review, published in 2016, included 6 retrospective and 3 prospective studies, and all the prospective studies but not the retrospective ones were also included in our review. 31,37,38 The prior review did not include 6 studies that proved eligible in our systematic review, namely 2 conducted among men (1 full text article 36 and 1 conference abstract 29 ), 2 conducted among both genders that were reported before the publication of their review, 32,33 and 2 (both conducted among men) that were published after their review appeared. 34,39 The prior review did not conduct a meta-analysis, nor did the authors provide estimates of the impact of nocturia on the absolute risks of falls or fractures, or assess the quality of evidence.…”

Section: Relation To Prior Workmentioning

confidence: 99%

The Impact of Nocturia on Falls and Fractures: A Systematic Review and Meta-Analysis

et al. 2020

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AEP)Purpose: Although nocturia is associated with various comorbidities, its impact on falls and fractures remains unclear. We performed a systematic review and meta-analysis to evaluate the association between nocturia and falls and fractures as a prognostic and as a causal risk factor. Materials and Methods: We searched PubMedÒ, ScopusÒ, CINAHL (Cumulative Index to Nursing and Allied Health Literature) and abstracts of major urological meetings up to December 31, 2018. We conducted random effects meta-analyses of adjusted relative risks of falls and fractures. We applied the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach to rate the quality of evidence for nocturia as a prognostic and causal factor of falls and fractures. Results: Among 5,230 potential reports 9 observational longitudinal studies provided data on the association between nocturia and falls or fractures (1 for both, 4 for falls, 4 for fractures). Pooled estimates demonstrated a risk ratio of 1.20 (95% CI The corresponding author certifies that, when applicable, a statement(s) has been included in the manuscript documenting institutional review board, ethics committee or ethical review board study approval; principles of Helsinki Declaration were followed in lieu of formal ethics committee approval; institutional animal care and use committee approval; all human subjects provided written informed consent with guarantees of confidentiality; IRB approved protocol number; animal approved project number.

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Risk factors for fracture in elderly men: a population-based prospective study

Cited by 24 publications

References 32 publications

Zolpidem Use and Risk of Fracture in Elderly Insomnia Patients

Zolpidem Use and Risk of Fracture in Elderly Insomnia Patients

Impact of androgen suppression and zoledronic acid on bone mineral density and fractures in the Trans‐Tasman Radiation Oncology Group (TROG) 03.04 Randomised Androgen Deprivation and Radiotherapy (RADAR) randomized controlled trial for locally advanced prostate cancer

The Impact of Nocturia on Falls and Fractures: A Systematic Review and Meta-Analysis

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