Risk Factors for Fatality among Confirmed Adult Dengue Inpatients in Singapore: A Matched Case-Control Study

Thein, Tun-Linn; Leo, Yee Sin; Fisher, Dale; Low, Jenny; Oh, H. M. L.; Gan, Victor C.; Wong, Joshua; Lye, David C.

doi:10.1371/journal.pone.0081060

Cited by 65 publications

(84 citation statements)

References 31 publications

(47 reference statements)

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“…In the study of thein leo et al 4% had severe hepatic impairment and 4 patients had renal impairment, maximum creatinine was 2.1 mg /dl, and 4 patients had ARDS. 13 In this study cases showed sinus braycardia in 60%, first degree heart block in 11%, and ventricular ectopics in 15% cases. While in other studies Gupta V et al showed 18% Brady cardia, 64% relative bradycardia, and 14% sinus tachycardia.…”

Section: Resultssupporting

confidence: 46%

To study cardiac manifestations in patients presenting with dengue infection and to find out the correlation of cardiac manifestations to warning signs of dengue

Yadav

Kumar

2017

Int J Adv Med

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Background: This study was done to observe the presence of Electrocardiographic (ECG) changes in patients presenting with dengue infection and to evaluate whether there were any related clinical cardiac manifestations and to find out the correlation of cardiac manifestations to warning signs of dengue.Methods: The study was conducted at MLN Medical College, Allahabad in the Department of Medicine between July 2016 to December 2016. One hundred consecutive patients aged 18 years or more with positive dengue serology were interviewed and examined. ECG was done for all patients. The data was analyzed using statistical significance tests.Results: Thirty-six patients had no warning signs, 64 patients had warning signs, out of which 43 patients had two or more warning signs while 21 patients had single warning sign. Most common warning sign in this study was abdominal pain (50%) and Vomiting (45 %) while hepatomegaly was the least common warning sign. The most common cardiac abnormalities noted were rhythm abnormalities of which the commonest was sinus bradycardia, found in 60 percent. There was statistically significant correlation between cardiac manifestations and all the warning signs except lethargy/restlessness and hepatomegaly.Conclusions: The most common cardiac manifestations noted were transient rhythm abnormalities, of which sinus bradycardia was the commonest. There was no evidence of myocarditis in any of the patients. There was statistically significant correlation between cardiac manifestations and all the warning signs except lethargy/restlessness and hepatomegaly.

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Section: Resultssupporting

confidence: 46%

To study cardiac manifestations in patients presenting with dengue infection and to find out the correlation of cardiac manifestations to warning signs of dengue

Yadav

Kumar

2017

Int J Adv Med

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“…However, data on comorbidities are not included in the SINAN, and can only be obtained through investigation of fatal dengue cases [33][34][35][36] .…”

Section: Discussionmentioning

confidence: 99%

Molecular and clinical epidemiological surveillance of dengue virus in Paraíba, Northeast Brazil

Guerra-Gomes

Gois

Peixoto

et al. 2017

Rev. Soc. Bras. Med. Trop.

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“…No observamos diferencias en cuanto a la presencia de dolor abdominal en pacientes fallecidos, cuando comparados con aquellos pacientes que no fallecieron, a diferencia de lo reportado por Thein y (15) col , quienes comparando los factores de riesgo en casos (pacientes fallecidos) y controles (pacientes no fallecidos), han demostrado que la presencia de dolor abdominal fue significativamente más frecuente en los casos que en los controles (p<0,05).…”

Section: Discussionunclassified

“…Sin embargo, Mallhi y colaboradores , describen un incremento en la estancia hospitalaria (p<0,01, OR 2.3) no así de mortalidad en los pacientes que presentaron manifestaciones hemorrágicas. Asimismo, Thein y colaboradores no demostraron una asociación de la presencia de manifestaciones (15) hemorragias con mortalidad .…”

Section: Discussionunclassified

Risk factors associated with dengue mortality in children under 15 years of age in Paraguay, 2010-2013

Cuéllar

Lovera

Arbo

2017

Pediatr. (Asunción)

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136Pediatr (Asunción). 2017;44(2):136-142 (mayo-agosto) 2017Factores de riesgo asociados a mortalidad por Dengue en menores de 15 años. Paraguay, periodo 2010Paraguay, periodo -2013 Risk factors associated with dengue mortality in children under 15 years of age in Paraguay, 2010Paraguay, -2013 (1,2) RR=6,22,9), manifestaciones clínicas hemorrágicas (p<0,01, RR 4,5, 95% CI 1,6 -12,8), presencia de Síndrome de shock por dengue (p<0,01, RR 83,5, 95% CI 40,6 -172,1) y pacientes con patologías de base (p<0. 001; RR=86,32, IC 95% 38,8). La mayor frecuencia de hospitalización se observó en el grupo etario <1 año (591/3475, 17%), significativamente mayor comparado con los grupos de 1 a 4 años (6,5%) y 5 a 14 años (5687/42455. 13.4%) (p<0.00001; RR=2,51; IC 95% 2,3 -2,7). Los Conclusiones: factores de riesgo asociados con el incremento de la mortalidad fueron la edad <1 año, las manifestaciones ABSTRACT Introduction: Dengue is the most important vector-borne disease in the Americas, and especially in Paraguay, with a sustained increase in outpatient cases, hospitalizations, and dengue deaths in the last 10 years, affecting all groups of the pediatric age group.To identify factors Objective: associated with mortality in children less than 15 years of age with diagnosis of dengue in the period 2010-2013. Materials and Methods: An observational, descriptive, retrospective study. The data were obtained from the weekly epidemiological bulletin of the Ministry of Public Health.During the period 2010 to 2013, 57,483 Results: children under the age of 15 years were diagnosed with dengue, requiring hospitalization in 12.2% (7,029 / 57,483). The mortality (number of deaths / number of total cases) in the study period was 0.055% (32 / 57,483), with a casefatality rate of 0.03%, 0.05%, 1.3% and 0.05%, respectively, in the years 2010 to 2013 respectively. The factors associated with increased mortality were age <1 year (p <0.001, RR = 6.22,, hemorrhagic clinical manifestations (p <0.01, RR 4.5, 95 % CI 1.6 -12.8), presence of dengue shock syndrome (p <0.01, RR 83.5, 95% CI 40.6 -172.1) and patients with baseline pathologies (p < 0.001, RR = 86.32,. The highest frequency of hospitalization was observed in the age group <1 year (591/3475, 17%), significantly higher compared to the groups of 1 to 4 years (6.5%) and 5 to 14 years (5687/42455. 13.4%) (p <0.00001; RR = 2.51; 95% CI 2.3-2.7). Conclusions: Risk factors associated with increased mortality were age <1 year, clinical manifestations of hemorrhagic fever, presence of shock syndrome due to dengue on admission, and underlying pathologies. The present study shows the great impact of dengue in Paraguay in terms of morbidity and mortality. The identification of factors associated with mortality may

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Risk Factors for Fatality among Confirmed Adult Dengue Inpatients in Singapore: A Matched Case-Control Study

Cited by 65 publications

References 31 publications

To study cardiac manifestations in patients presenting with dengue infection and to find out the correlation of cardiac manifestations to warning signs of dengue

To study cardiac manifestations in patients presenting with dengue infection and to find out the correlation of cardiac manifestations to warning signs of dengue

Molecular and clinical epidemiological surveillance of dengue virus in Paraíba, Northeast Brazil

Risk factors associated with dengue mortality in children under 15 years of age in Paraguay, 2010-2013

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