Risk Factors for Early Postoperative Complications after Surgery for Crohn's Disease

Joksimovic, Vladimir; A, Karagjozov; Jota, Gjorgji; Milev, Ilija; Gelevski, Radomir

doi:10.2478/afmnai-2014-0018

Cited by 2 publications

(2 citation statements)

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“…Yamamoto et al retrospectively analyses 343 patients underwent intestinal anastomosis operations and found that an albumin level less than 30 g/L was an independent risk factor for IASCs [ 9 ]. However, there are also several studies failed to find out the significant correlation between albumin level and the happening of IASCs [ 11 , 21 , 22 ]. Therefore, the relationship between albumin level and postoperative IASCs remains controversial and data from Chinese patients with CD are limited.…”

Section: Discussionmentioning

confidence: 99%

“…The serum albumin measurement is convenient and inexpensive [ 20 ], which makes it a potential candidate for practical predictive index. Although several studies have indicated the possible correlation between albumin level and the risk for IASCs, data from Asian population is scare and controversial [ 11 , 21 , 22 ]. Therefore, we designed this study, aiming to evaluate the impact of preoperative hypoalbuminemia on the development of IASCs after primary anastomosis for CD.…”

Section: Introductionmentioning

confidence: 99%

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Preoperative hypoalbuminemia is associated with an increased risk for intra-abdominal septic complications after primary anastomosis for Crohn’s disease

Liu

Zhou

et al. 2017

Gastroenterology Report

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ObjectiveThe aim of this study was to evaluate the impact of preoperative hypoalbuminemia on the development of intra-abdominal septic complications (IASCs) after primary anastomosis for patients with Crohn’s disease (CD).MethodsAll CD patients undergoing bowel resection with a primary anastomosis during the study period from 2007 to 2015 were enrolled. The association of preoperative hypoalbuminemia (<30 g/L) with the risk for IASCs were assessed using both univariate and multivariate analyses.ResultsA total of 124 eligible patients were included, 117 (94.4%) of whom had available preoperative albumin level. Preoperative hypoalbuminemia occurred in 13 (11.7%) patients. The duration from diagnosis to surgery was longer for patients with preoperative hypoalbuminemia than those without (p = 0.012). Patients with preoperative hypoalbuminemia were more likely to have a history of preoperative use of 5-aminosalicylic acid (p = 0.013) and have an intraoperative finding of small bowel obstruction (p = 0.015). Of all patients, 24 (19.4%) developed postoperative IASCs. Univariate analysis showed that patients with preoperative hypoalbuminemia had an increased risk for IASCs (p = 0.012). Multivariate analysis confirmed the association between preoperative hypoalbuminemia and IASCs (odds ratio 4.67, 95% confidence interval: 1.28–17.04, p = 0.02). Similar findings were also obtained when preoperative albumin level was analysed as a continuous variable (p = 0.019).ConclusionsPreoperative hypoalbuminemia is a significant predictor for the development of postoperative IASCs in CD patients after bowel resection with a primary anastomosis. Favorable preoperative nutrition status might lessen the risk for IASCs.

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