Risk Factors for Early Postoperative Small Bowel Obstruction after Elective Colon Cancer Surgery: An Observational Study of 1,244 Consecutive Patients

Wang, Xiaojie; Chi, Pan; H, Lin; Lu, Xingrong; Huang, Ying; Xu, Zongbin; Huang, Shenghui; Sun, Yan-Wu; Ye, Daoxiong

doi:10.1159/000468155

Cited by 12 publications

(8 citation statements)

References 13 publications

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“…The current study found a close relationship between preoperative serum albumin level and EPSBO, which indicates that poor systemic nutritional status increases the risk of EPSBO after right colectomy. This is consistent with the findings of Pan Chi et al [ 14 ], who hypothesized that preoperative low albumin induced EPSBO. Hypoproteinemia leads to intestinal swelling, which results in a local inflammatory response in the small intestine and increases the risk of EPSBO.…”

Section: Discussionsupporting

confidence: 93%

“…After multivariate analysis and controlling for confounding factors, a history of abdominal surgery was not an independent risk factor for EPSBO ( P = 0.111). A long operative time was considered a very important independent risk factor in current and previous studies [ 4 , 12 , 14 , 22 ]. Therefore, surgeons should complete the operation as soon as possible while ensuring surgical treatment to reduce complications caused by long operative times.…”

Section: Discussionmentioning

confidence: 98%

“…Therefore, there is a need to establish a predictive model of EPSBO after right hemicolectomy and determine controllable risk factors. Few previous studies have explored risk factors for EPSBO after colorectal cancer surgery, including, male sex, operative time, ASA > grade 3, open surgery, emergency surgery, intraoperative blood loss, previous abdominal surgery history, and defunctioning ileostomy [4][5][6][12][13][14]. The purpose of the current study was to construct a nomogram to predict the incidence of EPSBO after right colectomy.…”

Section: Introductionmentioning

confidence: 99%

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Novel nomogram for predicting risk of early postoperative small bowel obstruction after right colectomy for cancer

et al. 2022

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Background Early postoperative small bowel obstruction (EPSBO) is a common complication after colorectal cancer surgery. Few studies have specifically studied risk factors for early small bowel obstruction after right colectomy, especially in establishing predictive models. The purpose of the current study was to establish an effective nomogram to predict the incidence of EPSBO after right colectomy. Methods The current study retrospectively analyzed data from a total of 424 patients who underwent right colectomy in a local hospital from January 2014 to March 2021. A logistic regression model was used to identify potential risk factors for EPSBO after right colectomy. A nomogram was established by independent risk factors, and the prediction performance of the model was evaluated using an area under the receiver operating characteristic (ROC) curve and calibration chart. Results A total of 45 patients (10.6%) developed early small bowel obstruction after right colectomy. Male sex, emergency operation, history of abdominal surgery, open surgery, long operative time, anastomotic leakage, and preoperative albumin were closely related to EPSBO. Analysis of postoperative rehabilitation indices showed that EPSBO remarkably slowed the postoperative rehabilitation speed of patients. Multivariate logistic regression analysis showed that male sex, open surgery, operative time, and anastomotic leakage were independent risk factors (P < 0.05), and the operation time had the greatest impact on EPSBO. On the basis of multivariate logistic regression, a nomogram was constructed, which showed moderate accuracy in predicting EPSBO, with a C-statistic of 0.716. The calibration chart showed good consistency between the predicted probability and ideal probability. Conclusion The current study constructed a nomogram based on the clinical data of patients who underwent right colectomy, which had moderate predictability and could provide reference value for clinicians to evaluate the risk of EPSBO.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Novel nomogram for predicting risk of early postoperative small bowel obstruction after right colectomy for cancer

et al. 2022

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“…Postoperative bowel obstruction was a quite common complication after colorectal surgery [ 10 ]. Previous studies showed that risk factors of prolonged or early postoperative bowel obstruction for patients after colorectal surgery [ 11 – 13 ]. But few studies analyzed multiple risk factors for early postoperative bowel obstruction and no one previous study was found focusing on the prediction model of early postoperative bowel obstruction [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Risk factors of early postoperative bowel obstruction for patients undergoing selective colorectal surgeries

et al. 2021

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Objective Postoperative bowel obstruction was one of the most severe complications in patients who received colorectal surgeries. This study aimed to explore risk factors of early postoperative obstruction and to construct a nomogram to predict the possibility of occurrence. Methods The records of 1437 patients who underwent elective colorectal surgery in Peking University People’s Hospital from 2015 to 2020 were retrospectively collected. Risk factors of early postoperative bowel obstruction were identified by logistic regression analysis and a nomogram was then constructed. Bootstrap was applied to verify the stability of the model. Results COPD, hypothyroidism, probiotic indications, duration of antibiotics, and time to postoperative feeding were identified as independent risk factors and were put into a nomogram for predicting early postoperative bowel obstruction. The nomogram showed robust discrimination, with the area under the receiver operating characteristic curve was 0.894 and was well-calibrated. Conclusion A nomogram including independent risk factors of COPD, hypothyroidism, probiotic indications, duration of antibiotics, and time to postoperative feeding were established to predict the risk of early postoperative bowel obstruction.

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“…Postoperative bowel obstruction was a quite common complication after colorectal surgery [8]. Previous studies showed that risk factors of prolonged or early postoperative bowel obstruction for patients after colorectal surgery [9][10][11]. But few studies analyzed multiple risk factors for early postoperative bowel obstruction and no one previous study was found focusing on the prediction model of early postoperative bowel obstruction [12].…”

Section: Discussionmentioning

confidence: 99%

Risk Factors of Early Postoperative Bowel Obstruction for Patients Undergoing Selective Colorectal Surgeries

Yang

Gao

Zhao

et al. 2021

Preprint

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Objective: Postoperative bowel obstruction was one of the most severe complications in patients received colorectal surgeries. The aim of this study was to explore risk factors of early postoperative obstruction and to construct a nomogram to predict the possibility of occurrence. Methods: The records of 1437 patients who underwent selective colorectal surgery in Peking University People’s Hospital from 2015 to 2020 was retrospectively collect. Risk factors of early postoperative bowel obstruction were identified by logistic regression analysis and a nomogram was then constructed. Bootstrap was applied to verify the stability of the model. Results: COPD, hypothyroidism, probiotic indications, duration of antibiotics, and time to postoperative feeding were identified as independent risk factors and were put into a nomogram for predicting early postoperative bowel obstruction. The nomogram showed a robust discrimination, with area under the receiver operating characteristic curve was 0.894 and was well calibrated. Conclusion: A nomogram including independent risk factors of COPD, hypothyroidism, probiotic indications, duration of antibiotics, and time to postoperative feeding were established to predict the risk of early postoperative bowel obstruction.

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Risk Factors for Early Postoperative Small Bowel Obstruction after Elective Colon Cancer Surgery: An Observational Study of 1,244 Consecutive Patients

Cited by 12 publications

References 13 publications

Novel nomogram for predicting risk of early postoperative small bowel obstruction after right colectomy for cancer

Novel nomogram for predicting risk of early postoperative small bowel obstruction after right colectomy for cancer

Risk factors of early postoperative bowel obstruction for patients undergoing selective colorectal surgeries

Risk Factors of Early Postoperative Bowel Obstruction for Patients Undergoing Selective Colorectal Surgeries

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