Risk factors for early postoperative morbidity and mortality in patients underwent radical surgery for gastric carcinoma: A single center experience

Vural, Selahattin; Civil, Osman; Kement, Metin; Altuntas, Yunus Emre; Okkabaz, Nuri; Gezen, Cem; Haksal, Mustafa; Gündoğan, Ersin; Öncel, Mustafa

doi:10.1016/j.ijsu.2013.09.008

Cited by 9 publications

(5 citation statements)

References 25 publications

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“…Cardiovascular disease and high ASA scores were previously reported as risk (16) reported that preoperative cardiovascular disease was an independent risk factor for anastomotic leakage (odds ratio=1.826, 95% interval confidence=1.088-3.067; p<0.001). In addition, Vural et al (17) reported that a high ASA score (≥3) was significantly associated with an increased rate of postoperative complications compared with a low ASA score (≤2) (odds ratio=2.285, p=0.033). In our study, the ratio of preoperative cardiovascular disease to a high ASA score was significantly higher in the older patients than in the younger ones (p=0.009 and p=0.006, respectively), which may have resulted in the occurrence of anastomotic leakage.…”

Section: Discussionmentioning

confidence: 99%

The Short- and Long-term Outcomes of Gastrectomy in Elderly Patients With Gastric Cancer

Komori

Kano

Aoyama

et al. 2020

In Vivo

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Background: The short-and long-term outcomes of gastrectomy in elderly patients with gastric cancer have not been fully evaluated. Patients and Methods: Patients who underwent gastrectomy were classified into two groups: Nonelderly patients (<80 years old) and elderly patients (≥80 years old). The surgical morbidity, overall and cancerspecific survival in the two groups were compared. Results: A total of 411 patients were evaluated. The rate of overall complication was 29.4% in the non-elderly and 32.4% in the elderly (p=0.699). In the elderly, the overall and cancerspecific survival rates at 5 years after surgery were inferior to those of the younger group (59.8% vs. 66.7%, p=0.103 and 67.9% vs. 78.2%, p=0.028, respectively). Conclusion: The short-term outcomes after gastrectomy were almost equal for the two groups in the present study. The prognosis was poor in elderly patients, especially those with advanced gastric cancer. Gastric cancer is one of the main health problems (1). It is the fifth-most frequently diagnosed cancer and the third leading cause of cancer death worldwide. The 5-year survival rate ranges from 10.3% to 57.9% in all stages (1). Surgical resection is accepted as curative treatment for gastric cancer (2). However, complications after gastrectomy remain a clinically relevant problem. Indeed, the morbidity and mortality after gastric resection have been reported in the range of 22.0-42.9% and 0%-0.8%, respectively (3-6). The number of elderly patients is increasing worldwide, with the proportion of elderly over 80 years old increasing at a rate of 4.0% annually (7). In elderly patients, conditions such as functional impairment and physiological problems are common, which can result in postoperative complications and poor survival (8-10). Surgical procedures, perioperative care, and surgical strategies should thus be carefully planned for elderly patients. However, there have been few previous studies reporting on the safety and feasibility of gastric cancer surgery for older patients. Furthermore, the long-term survival of elderly patients after gastric cancer surgery is largely still unknown. It is therefore essential to clarify characteristics of elderly patients and assess the effect of age on their treatment outcomes. The present retrospective study compared the short-and long-term outcomes after gastric cancer surgery in elderly patients with those in non-elderly patients. Patients and Methods Patients. The study subjects were collected from among consecutive patients in the hospital registry indicated for gastric cancer surgery at the Yokohama City University Hospital between January 2000 and September 2012. Patients with the following were enrolled: Histologically proven gastric adenocarcinoma, no metachronous or concurrent malignancies, and gastrectomy for gastric cancer with curative D1+ or D2 dissection as a first-line treatment. The removed tumor specimens were examined histopathologically, and staging was performed based on tumor invasion and lymph node metastasis, in line with th...

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Section: Discussionmentioning

confidence: 99%

The Short- and Long-term Outcomes of Gastrectomy in Elderly Patients With Gastric Cancer

Komori

Kano

Aoyama

et al. 2020

In Vivo

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“…The association of surgical duration with MPO is variously discussed. There was no statistically established link between MPO and duration of surgical intervention according to Elias et al [13] in a series of 416 patients operated on in general surgery, but also Vural et al [10] in multivariate analysis in a single-center cohort of 160 patients operated on for gastric carcinoma (mean duration of surgical intervention = 3 hours).…”

Section: Discussionmentioning

confidence: 93%

“…In the series by Marzougui et al [12], the mortality rate was significantly higher when surgery was dictated by abdominal neoplastic pathology (p < 0.001). On their side, Vural et al (p=0.018) [10] reported an absence of significant relationship between mortality after surgery and stage I tumors. This last result corroborates ours with regard to abdominal tumors, but acute generalized peritonitis was associated with MPO, with Volume 08; Issue 14 J Surg, an open access journal ISSN: 2575-9760 a 6-fold increased risk (p=0.004; OR: 6.0) in univariate analysis .…”

Section: Discussionmentioning

confidence: 97%

“…Although taken into account among the comorbidities classified according to their degree of severity in the ASA score, arterial hypertension is less cited in its association with POD. In a single-center study published in 2013 focusing on early MPO factors in patients who underwent radical surgery for gastric carcinoma, Vural et al (2013) [10] observed an absence of a statistically significant link between high blood pressure (hypertension) and POD. In our study, of the six hypertensive patients, 2 died, i.e.…”

Section: Discussionmentioning

confidence: 99%

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Factors Associated with Postoperative Mortality in the General Surgery Department of Ignace Deen Hospital of Conakry University Hospital

2023

J Surg

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Introduction:The aim of this study was to analyze the prevalence and factors associated with Postoperative Mortality (POM) in the general surgery department of the Ignace Deen hospital of the Conakry University Hospital. Material and methods:This was a Four-month prospective cohort (September to December 2018) conducted in the general surgery department of the Ignace Deen hospital of the Conakry University Hospital. The patients were divided into groups of "deceased" and "alive" postoperatively. The qualitative and quantitative variables were compared in these two groups. The univariate logistic regression then the multivariate one was carried out.Results: a series of 399 operated on was included in the analysis. The median age was 26 years (P25=18; p75=42). The prevalence of postoperative mortality was 3.5% (95% CI : 1.8 -5.5) . multivariate analysis by logistic regression, two factors associated with postoperative mortality were identified: advanced age ≥ 60 years (OR: 9.8; CI: 2.5 -37.7) and resection of small bowel loops ( OR: 8.3; CI: 1.3 -52.4). Conclusion :The analysis of mortality factors in this study allowed us to note a high risk of postoperative mortality in patients of advanced age and in those in whom a small intestinal resection had been performed.Improving the surgical prognosis will require the identification of mortality factors and their adequate management.

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“…Ряд авторов отмечают, что у данной группы больных объем оперативного вмешательства и лимфодиссекции являются определяющим фактором риска осложненного течения раннего послеоперационного периода. [1,4,5,6] В то же время, современные успехи анестезиологии и реаниматологии, совершенствование хирургической техники и внедрение новых технологий лечения РЖ способствует успешному выполнению высокотравматичных хирургических вмешательств и обеспечивает хорошие непосредственные результаты оперативного лечения больных РЖ групп высокого хирургического риска. [1,7,8] Перспективным методом в комплексном лечении пациентов является фотодинамическая терапия (ФДТ), основанная на способности биологических объектов (раковые клетки, воспалительные ткани, микробы) накапливать красители -фотосенсибилизаторы.…”

Section: Introductionunclassified

Photodynamic therapy in the treatment of stomach cancer

Иванова¹,

Viun²

2018

Photobiology and Photomedicine

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The analysis of the results of treatment of 10 patients with gastric cancer with high surgical risk, who in the treatment complex used photodynamic therapy with photosensitizer Photolon and further irradiation with a semiconductor laser with a wavelength of λ = 0.67 μm cross-irradiation fields introduced through the biopsy channel of the endoscope. Endoscopic PDT can be used at the stage of combined treatment in combination with drug therapy and surgical interventions and is an effective means of preventing the development of esopha- geal-small intestinal anastomosis failures in the early postoperative period. Endoscopic PDT can also be used in the postoperative period as a prophylaxis of early postoperative complications in cases of detection of tumor cells in the margins of resection.

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Risk factors for early postoperative morbidity and mortality in patients underwent radical surgery for gastric carcinoma: A single center experience

Cited by 9 publications

References 25 publications

The Short- and Long-term Outcomes of Gastrectomy in Elderly Patients With Gastric Cancer

The Short- and Long-term Outcomes of Gastrectomy in Elderly Patients With Gastric Cancer

Factors Associated with Postoperative Mortality in the General Surgery Department of Ignace Deen Hospital of Conakry University Hospital

Photodynamic therapy in the treatment of stomach cancer

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