Risk factors for disease progression in COVID-19 patients

Lee, Hee Jin; Park, Yu Kyung; Kim, Bong Ok; Park, Donghwi

doi:10.1186/s12879-020-05144-x

Cited by 128 publications

(119 citation statements)

References 21 publications

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“…In the meta-analysis conducted by Hariyanto and Kurniawan, 38 7 observational studies were analyzed. 45 47 48 49 50 51 52 In each study, dyslipidemia or hyperlipidemia was defined according to patients' history based on electronic medical records regardless of additional laboratory testing or the use of lipid-lowering drugs. Four of the 7 studies were conducted in China, and 1 study each from the US, France, and Korea was included.…”

Section: Discussionmentioning

confidence: 99%

The Potential Role of Dyslipidemia in COVID-19 Severity: an Umbrella Review of Systematic Reviews

Choi

Kim

Kang

2020

J Lipid Atheroscler

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Objective: The aim of this study was to analyze the available knowledge about the potential association between dyslipidemia and the severity of coronavirus disease 2019 (COVID-19) as reported in previous published systematic reviews. Methods: In this umbrella review (an overview of systematic reviews), we investigated the association between dyslipidemia and COVID-19 severity. A systematic search was performed of 4 main electronic databases (MEDLINE, Embase, Scopus, and the Cochrane Library databases) from inception until August 2020. We evaluated the methodological quality of the included studies using the A MeaSurement Tool to Assess systematic Reviews (AMSTAR) 2 tool and used the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to assess the quality of evidence for the outcome. In addition, we evaluated the strengths and limitations of the evidence and the methodological quality of the available studies. Results: Out of 35 articles identified, 2 systematic reviews were included in the umbrella review. A total of 7,951 COVID-19-positive patients were included. According to the AMSTAR 2 criteria and GRADE system, the quality of the included studies was not high. A history of dyslipidemia is likely to be associated with the severity of COVID-19 infection, but the contrary is the case for cholesterol levels at hospitalization. Conclusions: Although existing research on dyslipidemia and COVID-19 is limited, our findings suggest that dyslipidemia may play a role in the severity of COVID-19 infection. More adequately powered studies are needed.

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Section: Discussionmentioning

confidence: 99%

The Potential Role of Dyslipidemia in COVID-19 Severity: an Umbrella Review of Systematic Reviews

Choi

Kim

Kang

2020

J Lipid Atheroscler

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“…The symptoms of this highly contagious disease include dry cough, fever, anosmia (loss of smell), weakness, headache, body pains, vomiting, sore throat, and respiratory difficulty, and the onset of symptoms ranges from 1-14 days (Ahmed, 2020;Wang et al, 2020). Some infected individuals may remain asymptomatic (without symptoms) after contracting the virus (Daniel & Oran, 2020;Lee et al, 2020), whereas among the symptomatic cases, the majority of them are mild or moderate (Bi et al, 2020;Chang et al, 2020), with about 10% being severe (Bi et al, 2020;Chang et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Attitude and preventive practices towards COVID-19 disease and the impact of awareness training on knowledge of the disease among correctional officers

Okoro¹,

Ekeroku

Nweze

et al. 2020

Emerald Open Res

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COVID-19 disease remains a public health emergency of international concern. Efforts at the global and national levels are being made to control its spread. The Nigerian Correctional Service is also proactive in the fight against the disease by organizing COVID-19 awareness training for correctional officers. We conducted a pre- and post-test assessment of COVID-19 knowledge among correctional officers in Enugu State Command to determine the impact of awareness training on their knowledge level. The study also assessed correctional officers’ attitude and preventive practices towards the disease. The mean knowledge score was 19.34 out of 25, and the awareness training significantly improved the participants’ COVID-19 knowledge. We found a significant moderate, positive correlation between knowledge and attitude/practice, and a significantly higher knowledge level among those with higher educational qualifications. The majority of the respondents (87.9%) believed that there were confirmed cases of COVID-19 in Nigeria, whereas 85.1%, 78.7%, and 75.9% believed that there were cases in other parts of the world, the world will win the battle against COVID-19, and that there will be successful control of the disease, respectively. Regular hand washing with soap and water was practiced by 87.9% of the participants, whereas 84.4%, 83%, and 58.9%, wore face masks in public places, practiced social distancing, and avoided crowded places, respectively. Obtaining information from multiple sources was the commonest (53.2%), and this was followed by the Nigeria Center for Disease Control (26.2%).

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“…Previous studies have roughly delineated several risk factors of poor progression of COVID-19, such as age, diabetes, neutrophil-to-lymphocyte ratio, obesity, and dyspnea [4][5][6][7][8]. Nevertheless, these studies usually investigated the association between a single risk factor and a subjective classi cation of cases, which is not suitable for an early risk assessment of multiple risk factors among an affected population.…”

Section: Introductionmentioning

confidence: 99%

Prediction Model of Severe Coronavirus Disease 2019(COVID-19) Cases Shows the Leading Risk Factor of Hypocalcemia

Dai

et al. 2020

Preprint

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Background A striking characteristic of Coronavirus Disease 2019(COVID-19) is the coexistence of clinically mild and severe cases. A comprehensive analysis of multiple risk factors predicting progression to severity is clinically meaningful. Methods The patients were classified into moderate and severe groups. The univariate regression analysis was used to identify their epidemiological and clinical features related to severity, which were used as possible risk factors and were entered into a forward-stepwise multiple logistic regression analysis to develop a multiple factor prediction model for the severe cases.Results 255 patients (mean age, 49.1±SD 14.6) were included, consisting of 184 (72.2%) moderate cases and 71 (27.8%) severe cases. The common symptoms were dry cough (78.0%), sputum (62.7%), and fever (59.2%). The less common symptoms were fatigue (29.4%), diarrhea (25.9%), and dyspnea (20.8%). The univariate regression analysis determined 23 possible risk factors. The multiple logistic regression identified seven risk factors closely related to the severity of COVID-19, including dyspnea, exposure history in Wuhan, CRP (C-reactive protein), aspartate aminotransferase (AST), calcium, lymphocytes, and age. The probability model for predicting the severe COVID-19 was P=1/1+exp (-1.78+1.02×age+1.62×high-transmission-setting-exposure +1.77×dyspnea+1.54×CRP+1.03×lymphocyte+1.03×AST+1.76×calcium). Dyspnea (OR=5.91) and hypocalcemia (OR=5.79) were the leading risk factors, followed by exposure to a high-transmission setting (OR=5.04), CRP (OR=4.67), AST (OR=2.81), decreased lymphocyte count (OR=2.80), and age (OR=2.78). Conclusions This quantitative prognosis prediction model can provide a theoretical basis for the early formulation of individualized diagnosis and treatment programs and prevention of severe diseases.

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Risk factors for disease progression in COVID-19 patients

Cited by 128 publications

References 21 publications

The Potential Role of Dyslipidemia in COVID-19 Severity: an Umbrella Review of Systematic Reviews

The Potential Role of Dyslipidemia in COVID-19 Severity: an Umbrella Review of Systematic Reviews

Attitude and preventive practices towards COVID-19 disease and the impact of awareness training on knowledge of the disease among correctional officers

Prediction Model of Severe Coronavirus Disease 2019(COVID-19) Cases Shows the Leading Risk Factor of Hypocalcemia

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