Risk factors for disability in older persons over 3-year follow-up

Balzi, Daniela; Lauretani, Fulvio; Barchielli, Alessandro; Ferrucci, Luigi; Bandinelli, Stefania; Buiatti, Eva; Milaneschi, Yuri; Guralnik, Jack M.

doi:10.1093/ageing/afp209

Cited by 130 publications

(132 citation statements)

References 22 publications

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“…For this reason, physical activity can intervene on the well-being of the elderly, helping to maintain physical function and consequently ADL, and protecting elderly people from the risk of frailty and nursing necessities. 53 Consequently, the maintenance of ADL has strong positive effects on the life of the elderly, contributing to successful ageing. 11,54 This study has some limits to consider.…”

Section: Discussionmentioning

confidence: 99%

Preventing Loss of Basic Activities of Daily Living and Instrumental Activities of Daily Living in Elderly

Candela

Zucchetti

Ortega

et al. 2015

Holistic Nursing Practice

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This study investigated the association between physical functioning and activities of daily living (ADL) of elderly people, taking into account the role of cognitive, psychological, and social factors. We administered physical, cognitive, psychological, and social instruments to investigate the level of basic and instrumental activities of daily living (BADL and IADL). The analysis showed that physical functioning was the only individual factor that was significantly linked with the level of BADL and IADL. This study underlines that physical functioning is the main individual characteristic directly associated with the level of BADL and IADL in old age.

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Section: Discussionmentioning

confidence: 99%

Preventing Loss of Basic Activities of Daily Living and Instrumental Activities of Daily Living in Elderly

Candela

Zucchetti

Ortega

et al. 2015

Holistic Nursing Practice

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“…However, advantage of the MeDi score is the potential to consider additional, synergistic or opposite effects of 9 food groups and therefore to minimize confounding and modification effects among nutritional variables. In the same way, we adjusted our analyses for energy intake, to achieve of an isocaloric diet and to reduce measurement error in the score [56][57]. Finally, we cannot rule out the possibility of residual confounding by other unknown risk or protective factors such as a general healthier lifestyle of MeDi adherents.…”

Section: Discussionmentioning

confidence: 99%

Adherence to a Mediterranean diet and onset of disability in older persons

et al. 2011

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“…SPPB scores were categorized as < 6, 6-10, and ‡ 10 as per previously published analyses from this cohort study. 26 Blood samples were collected in the morning after a 12-hr fast. Aliquots of serum and plasma were immediately obtained and stored at -80°C.…”

Section: Methodsmentioning

confidence: 99%

Relationship of Low-Circulating “Anti-Aging” Klotho Hormone with Disability in Activities of Daily Living among Older Community-Dwelling Adults

Crasto

Semba²,

Sun³

et al. 2012

Rejuvenation Research

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The aging suppressor gene klotho encodes a single-pass transmembrane protein klotho that in mice is known to extend life span when overexpressed and to resemble accelerated aging, with skeletal muscle atrophy and decreased bone mineral density, when expression is disrupted. We sought to examine the relationship between plasma klotho and disability in activities of daily living (ADL) in older community-dwelling adults. In a crosssectional study, plasma klotho was measured in a population-based sample of 802 adults, ‡ 65 years, who participated in the ''Invecchiare in Chianti'' (Aging in the Chianti Area) (InCHIANTI) study in Tuscany, Italy. The overall proportion of adults with ADL disability was 11.9%. Mean (standard deviation) klotho concentrations were 689 (238) pg/mL. From the lowest to the highest tertile of plasma klotho, 16.1%, 9.7%, and 5.6% of participants, respectively, had ADL disability ( p = 0.0004). Plasma klotho, per 1 standard deviation increase, was associated with ADL disability (odds ratio = 0.57, 95% confidence interval 0.35-0.93, p = 0.02) in a multivariate logistic regression model adjusting for age, education, cognition, physical activity, physical performance, total cholesterol, alcohol and tobacco use, and chronic diseases. Low plasma klotho concentrations were independently associated with ADL disability among older community-dwelling men and women.

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Risk factors for disability in older persons over 3-year follow-up

Abstract: higher level of physical activity and lower energy intake may be protective against the development in ADL and IADL disability in older persons.

Cited by 130 publications

References 22 publications

Preventing Loss of Basic Activities of Daily Living and Instrumental Activities of Daily Living in Elderly

Preventing Loss of Basic Activities of Daily Living and Instrumental Activities of Daily Living in Elderly

Adherence to a Mediterranean diet and onset of disability in older persons

Relationship of Low-Circulating “Anti-Aging” Klotho Hormone with Disability in Activities of Daily Living among Older Community-Dwelling Adults

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