Risk factors for development of internal neoplasms in koi carp Cyprinus carpio koi

Knüsel, F Ott; Doherr, Marcus G.; Knüsel, R.; Wahli, Thomas; Schmidt‐Posthaus, Heike

doi:10.3354/dao02860

Cited by 8 publications

(14 citation statements)

References 28 publications

(21 reference statements)

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“…Gonadal tumours in the carp/goldfish hybrids first became evident in 3 to 4 yr old fish, the age at which carp and goldfish normally become sexually mature. This age class is comparable to our study, as we found the highest number of fish with coelomatic neoplastic lesions in the age class of 3 to 6 yr (Ott Knüsel et al 2015). …”

supporting

confidence: 75%

“…Ultimately in all cases, the owner or the veterinarian noticed an abnormal abdominal swelling in the affected koi (see also Ott Knüsel et al 2015). The swelling was more or less uniform, firm to the touch and bilateral, and only few tumours showed a more unilateral appearance.…”

Section: Clinical Signsmentioning

confidence: 99%

“…To date, only few studies have reported on the oc currence of tumours in koi carp (Ishikawa & Taka yama 1977, Knüsel et al 2007, Sirri et al 2010, Ott Knüsel et al 2015. The few existing records report on neoplastic proliferations in the gills, liver, gonads and kidneys.…”

Section: Introductionmentioning

confidence: 99%

“…This equates to 22.4 tumour cases per year, or 0.24% of the whole diagnostic material of our veterinary clinic (fishdoc GmbH; www.fishdoc.ch). As the incidental tumour occurrence in other ornamental fish species is rare, an incidence of 0.24% per year was interpreted as high (Ott Knüsel et al 2015). Most of the affected koi (62%) were less than 6 yr old.…”

Section: Introductionmentioning

confidence: 99%

“…The cause of the swelling has to be ruled out by surgery or pathologically, with egg retention as the main differential diagnosis. In a recent study, the frequency of coelomatic tumours in a selected koi population in Switzerland was investigated (Ott Knüsel et al 2015). Out of 9300 fish included in the study, 1.2% developed coelomatic tumours between 2008 and 2012.…”

Section: Introductionmentioning

confidence: 99%

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Frequency and histologic characterization of coelomatic neoplasms in koi Cyprinus carpio koi

Knüsel¹,

Knüsel²,

Doherr³

et al. 2016

Dis. Aquat. Org.

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Koi carp presenting with coelomatic neoplastic lesions are of growing importance in Switzerland and elsewhere in Europe, as clinical diagnosis is usually difficult and prognosis is usually poor because of late recognition. To gain more information about this condition, between 2008 and 2012, 117 koi diagnosed with coelomatic tumours were included in this study. The nature and growth characteristics of these pathologic tissues were documented. Out of 117 koi, 48.9% (n = 57) were female; the ovary was the most often affected organ (35%, n = 41), and in 62.4% (n =73) of cases, the cells of origin were identified as stromal cells of the sex-cord and the tumours were identified as sex-cord stromal tumours. The characteristics of growth and histology showed that the majority of tumours were malignant.KEY WORDS: Koi carp · Neoplasm · Histopathology · Ovary · Testis · Sex-cord stromal tumour Resale or republication not permitted without written consent of the publisherDis Aquat Org 119: [219][220][221][222][223][224][225][226][227][228][229] 2016 To gain more information about the nature of neoplastic lesions in internal organs and the pathological features of these neoplasms, koi presenting with various abdominal neoplasms were examined between 2008 and 2012. Specifically, possible sex-specific differences, the organs affected, the tissue/cells of origin and the characteristics of neoplastic growth were investigated. MATERIALS AND METHODS Origin of samplesBetween 2008 and 2012, all koi carp with an enlarged abdomen, which were euthanized or died in our veterinary clinic, were examined pathologically. A standard necropsy was performed. Those fish showing a coelomatic mass suspected to be a tumour were included in this study, for a total of 117 animals. As there was no recurrence of tumour masses in the same animal, 1 tumour case always corresponds to 1 animal. If possible, the sex of the affected animal was recorded. Macroscopic changes of internal organs, including extent and appearance of the coelomatic mass (colour, surface, cut section and texture) were recorded in 62 cases. In all 117 cases, tissue samples of different representative areas were fixed and stored in 10% buffered formalin and sent for analysis to the Centre for Fish and Wildlife Health (University of Bern). These samples were identified histologically as coelomatic neoplastic lesions. This criterion was used for the final decision to include the animals in this study. Histopathology and immunohistochemistry (IHC)Formalin-fixed samples were paraffin-embedded and routinely processed. Three or 4 serial sections were prepared: the first sections were stained with haematoxylin-eosin (H&E), the remaining sections were used for IHC staining.As a basis to classify the neoplasms, criteria defined in the World Health Organization classifications for tumours in domestic animals (Kennedy et al. 1998, Head et al. 2003, Meuten et al. 2007) were used.Because of limited availability of antibodies working properly on our koi carp tissue, only an epithelia...

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supporting

confidence: 75%

Section: Clinical Signsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Frequency and histologic characterization of coelomatic neoplasms in koi Cyprinus carpio koi

Knüsel¹,

Knüsel²,

Doherr³

et al. 2016

Dis. Aquat. Org.

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Noninfectious Diseases (Other)

Hadfield

2021

Clinical Guide to Fish Medicine

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Cytology of a seminoma in a koi (Cyprinus carpio): a rapid diagnostic tool

Pigoli,

Ghisleni,

Armando

et al. 2024

Vet Res Commun

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Koi(Cyprinus carpio) is an ornamental variety of common carp frequently kept as pets. Given their long lifespan, neoplasia, albeit uncommon, may occur in these animals, and only a few studies have faced their cytological diagnosis. In the present case, a koi carp was referred to the clinicians due to coelomic swelling. The carp underwent surgery, which revealed an enlargement of both testes. Testicular samples were cytologically and histologically examined. The lesion was diagnosed as a seminoma since it was composed of round, large, atypical, and often multinucleated cells with round central nuclei and moderate cytoplasm. These tumors had the same appearance as seminomas in mammals and should be considered among differential diagnoses when coelomic swelling occurs in koi carp. Seminomas in koi carp are diagnosed histologically, but cytology, a rapid and cheap exam executable in all veterinary clinical facilities, could be a relevant preliminary diagnostic tool that may influence the entire diagnostic process.

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Risk factors for development of internal neoplasms in koi carp Cyprinus carpio koi

Cited by 8 publications

References 28 publications

Frequency and histologic characterization of coelomatic neoplasms in koi Cyprinus carpio koi

Frequency and histologic characterization of coelomatic neoplasms in koi Cyprinus carpio koi

Noninfectious Diseases (Other)

Cytology of a seminoma in a koi (Cyprinus carpio): a rapid diagnostic tool

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