Risk factors for developing liver cancer in people with and without liver disease

Suh, Jae Kyung; Lee, Jayoun; Lee, Jeong-Hoon; Shin, Sue; Tchoe, Ha Jin; Kwon, Jin-Won

doi:10.1371/journal.pone.0206374

Cited by 23 publications

(16 citation statements)

References 25 publications

(23 reference statements)

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“…1 HBV and HCV occurred in more than 50% and 25% of HCC patients, respectively. 29 HBV vaccination has been widespread for newborns since 2002 in China. 30 Screening reduces liver cancer incidence and mortality in the Chinese population.…”

Section: Dovepressmentioning

confidence: 99%

<p>Secular Trend of Cancer Death and Incidence in 29 Cancer Groups in China, 1990–2017: A Joinpoint and Age–Period–Cohort Analysis</p>

Liu¹,

Zhou²,

Wang³

et al. 2020

CMAR

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Purpose: China has a heavy cancer burden. We aimed to quantitatively estimate the secular trend of cancer mortality and incidence in China. Methods: We extracted numbers, age-specific and age-standardized rates of 29 cancer groups (from 1990 to 2017) from the Global Burden of Disease (GBD) study in 2017. We estimated rates of major cancer types for annual percent change by Joinpoint regression, and for age, period, and cohort effect by an age-period-cohort model. Results: In 2017, breast cancer had the highest incidence rate in females. Lung cancer had the highest mortality and incidence rates in males. Although the age-standardized incidence rate of prostate cancer ranked second highest in males, it increased by 112% from 1990 to 2017. Individuals aged over 50 years were at high risk of developing cancer, and the number of deaths at this age accounted for over 89% of all cancers in all age groups. When compared with the global average level, the age-standardized mortality and incidence rates of both liver and esophageal cancers were 2.1 times higher in China, and stomach, lung and nasopharyngeal cancers in China also had high levels (more than 1.5 times higher). During 1990-2017, most of the 29 cancers exhibited an increasing incidence trend, and Joinpoint regression demonstrated increasing mortality of some major cancers. The period effect indicated that the risk of mortality and incidence due to the main cancers generally increased during 1992-2017. Conclusion: Trend analysis provided information on the effects of prevention strategies and targeted interventions on the occurrence of different cancers. Etiological studies need to be conducted on some major cancers in the Chinese population.

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Section: Dovepressmentioning

confidence: 99%

<p>Secular Trend of Cancer Death and Incidence in 29 Cancer Groups in China, 1990–2017: A Joinpoint and Age–Period–Cohort Analysis</p>

Liu¹,

Zhou²,

Wang³

et al. 2020

CMAR

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“…Medical Aid beneficiaries are economically and socially vulnerable, and therefore more likely to develop more serious conditions. The liver cancer risk in patients with liver disease was higher among Medical Aid beneficiaries than among National Health Insurance beneficiaries [2]. Medical Aid beneficiaries had a higher suicide rate than National Health Insurance beneficiaries [4].…”

Section: Discussionmentioning

confidence: 99%

“…Compared to National Health Insurance beneficiaries, several studies have reported that Medical Aid beneficiaries had poor health status and received insufficient medical care. Medical Aid beneficiaries showed higher risks of chronic diseases [2, 3] and suicide [4], lower levels of medication adherence and continuity of treatment [5, 6], and lower effectiveness of behavioral intervention programs [7]. They also were more likely to receive lower-quality medical care [8–11], more vulnerable to environmental conditions [12, 13], and less likely to participate in national screening programs [14, 15].…”

Section: Introductionmentioning

confidence: 99%

Trends in life expectancy among medical aid beneficiaries and National Health Insurance beneficiaries in Korea between 2004 and 2017

2019

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Background Medical Aid beneficiaries in Korea are more likely to have poor health status and to receive insufficient healthcare services, but their life expectancy has not been compared with that of National Health Insurance beneficiaries. Methods We used the National Health Information Database in Korea to obtain aggregate data on the numbers of population and deaths according to calendar year (2004 to 2017), sex, age group, and insurance eligibility (Medical Aid or National Health Insurance). Between 2004 and 2017, a summed total of 697,503,634 subjects (combining numbers of subjects for 14 years) and 3,536,778 deaths, including 22,417,216 Medical Aid beneficiaries and 499,604 associated deaths, were used to construct annual abridged life tables. Results In 2017, the life expectancy of Medical Aid beneficiaries was 70.9 years, while that of National Health Insurance beneficiaries was 83.7 years. Between 2004 and 2017, life expectancy for Medical Aid beneficiaries increased by 8.7 years in men and 6.1 years in women, while life expectancy for National Health Insurance beneficiaries increased by 5.2 years in men and 4.5 years in women. The life expectancy difference between National Health Insurance beneficiaries and Medical Aid beneficiaries was especially great among men across all study periods. The life expectancy difference was 15.8 years for men and 8.9 years for women in 2017. Conclusions The life expectancy of Medical Aid beneficiaries was shorter than that of National Health Insurance beneficiaries. The government should implement policies to deliver more adequate health care to Medical Aid beneficiaries. Electronic supplementary material The online version of this article (10.1186/s12889-019-7498-2) contains supplementary material, which is available to authorized users.

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“…Approximately 75-85% of all liver cancer cases are classified as HCC and 10%-15% of cases are intrahepatic cholangiocarcinoma, according to Global Cancer Statistics 2018 from the International Agency for Research on Cancer. The most common risk factors for HCC are chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection, heavy alcohol intake, obesity, type 2 diabetes, and smoking (Lu et al, 2016a;Lu et al, 2016b;Suh et al, 2018). Many studies have revealed that the occurrence and development of HCC are associated with abnormal genetic changes and cancer-related signaling pathways (Koh et al, 2018;Peng et al, 2019;Pinato et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Integrative analysis of dysregulated lncRNA-associated ceRNA network reveals potential lncRNA biomarkers for human hepatocellular carcinoma

Zhang

Yang

et al. 2020

PeerJ

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Background Hepatocellular carcinoma (HCC) is an aggressive cancer with a poor prognosis and a high incidence. The molecular changes and novel biomarkers of HCC need to be identified to improve the diagnosis and prognosis of this disease. We investigated the current research concentrations of HCC and identified the transcriptomics-related biomarkers of HCC from The Cancer Genome Atlas (TGCA) database. Methods We investigated the current research concentrations of HCC using literature metrology analysis for studies conducted from 2008 to 2018. We identified long noncoding RNAs (lncRNAs) that correlated with the clinical features and survival prognoses of HCC from The Cancer Genome Atlas (TGCA) database. Differentially expressed genes (lncRNAs, miRNAs, and mRNAs) were also identified by TCGA datasets in HCC tumor tissues. A lncRNA competitive endogenous RNA (ceRNA) network was constructed from lncRNAs based on intersected lncRNAs. Survival times and the association between the expression levels of the key lncRNAs of the ceRNA network and the clinicopathological characteristics of HCC patients were analyzed using TCGA. Real-time polymerase chain reaction (qRT-PCR) was used to validate the reliability of the results in tissue samples from 20 newly-diagnosed HCC patients. Results Analysis of the literature pertaining to HCC research revealed that current research is focused on lncRNA functions in tumorigenesis and tumor development. A total of 128 HCC dysregulated lncRNAs were identified; 66 were included in the co-expressed ceRNA network. We analyzed survival times and the associations between the expression of 66 key lncRNAs and the clinicopathological features of the HCC patients identified from TCGA. Twenty-six lncRNAs were associated with clinical features of HCC (P < 0.05) and six key lncRNAs were associated with survival time (log-rank test P < 0.05). Six key lncRNAs were selected for the validation of their expression levels in 20 patients with newly diagnosed HCC using qRT-PCR. Consistent fold changes in the trends of up and down regulation between qRT-PCR validation and TCGA proved the reliability of our bioinformatics analysis. Conclusions We used integrative bioinformatics analysis of the TCGA datasets to improve our understanding of the regulatory mechanisms involved with the functional features of lncRNAs in HCC. The results revealed that lncRNAs are potential diagnostic and prognostic biomarkers of HCC.

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Risk factors for developing liver cancer in people with and without liver disease

Cited by 23 publications

References 25 publications

<p>Secular Trend of Cancer Death and Incidence in 29 Cancer Groups in China, 1990–2017: A Joinpoint and Age–Period–Cohort Analysis</p>

<p>Secular Trend of Cancer Death and Incidence in 29 Cancer Groups in China, 1990–2017: A Joinpoint and Age–Period–Cohort Analysis</p>

Trends in life expectancy among medical aid beneficiaries and National Health Insurance beneficiaries in Korea between 2004 and 2017

Integrative analysis of dysregulated lncRNA-associated ceRNA network reveals potential lncRNA biomarkers for human hepatocellular carcinoma

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