Risk factors for developing hyperoxaluria in children with Crohn’s disease

Abstract

Background For the purpose of a better understanding of enteric hyperoxaluria in Crohn’s disease (CD) in children and adolescents, we investigated the occurrence and risk factors for development of hyperoxaluria in those patients. Methods Forty-five children with CD and another 45 controls were involved in this cross-sectional study. Urine samples were collected for measurement of spot urine calcium/creatinine (Ur Ca/Cr), oxalate/creatinine (Ur Ox/Cr), and citrate/creatinine (Ur Citr/Cr) ratios. Fecal samples were also collected to detect the oxalyl-CoA decarboxylase of Oxalobacter formigenes by PCR. Patients were classified into 2 groups: group A (with hyperoxaluria) and group B (with normal urine oxalate excretion). The disease extent was assessed, and the activity index was calculated. Results According to the activity index, 30 patients (66.7%) had mild disease and 13 patients (28.9%) had moderate disease. There was no significant difference in Ur Ox/Cr ratio regarding the disease activity index. O. formigenes was not detected in 91% of patients in group A while it was detected in all patients in group B (p < 0.001). By using logistic regression analysis, the overall model was statistically significant when compared to the null model, (χ2 (7) = 52.19, p < 0.001), steatorrhea (p = 0.004), frequent stools (p = 0.009), and O. formigenes (p < 0.001). Conclusion Lack of intestinal colonization with O. formigenes, steatorrhea, and frequent stools are the main risk factors for development of enteric hyperoxaluria in CD patients. Identifying risk factors facilitates proper disease management in future studies. Graphical abstract A higher resolution version of the Graphical abstract is available as Supplementary information

Gut microbiota and common gastrointestinal diseases: a bidirectional two-sample Mendelian randomized study

“…Previous research on the link between gut microbiota and gastrointestinal diseases mainly relied on population-based retrospective studies (Gevers et al, 2014;Liu et al, 2021;Salem et al, 2023). These studies typically collected fecal samples from individuals with gastrointestinal disorders and used cross-sectional metabolomics analyses for concluding (Li et al, 2014;Da Silva et al, 2018;Caruso et al, 2020).…”