Risk factors for depression in adults: NR3C1 DNA methylation and lifestyle association

Borçoi, Aline Ribeiro; Mendes, Suzanny Oliveira; Santos, Joaquim Gasparini dos; Oliveira, Mayara Mota de; Moreno, Ivana Alece Arantes; Freitas, Flávia Vitorino; Pinheiro, Júlia Assis; Arpini, Juliana Krüger; Cunha, Ester Ribeiro; Archanjo, Anderson Barros; Assis, Arícia Leone Evangelista Monteiro de; Sorroche, Bruna Pereira; Arantes, Lídia Maria Rebolho Batista; Borloti, Elizeu; Silva, Adriana Madeira Álvares da

doi:10.1016/j.jpsychires.2019.10.011

Cited by 22 publications

(11 citation statements)

References 66 publications

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“…The other CpGs on the significant list was cg26495008 and cg10913456, both in the FKBP Prolyl Isomerase 5 (FKBP5) gene, previously associated with childhood maltreatment and depression (Klinger-König et al, 2019;Mehta et al, 2013); and risk of PTSD (Binder et al, 2008;Pape et al, 2018). The role of other significant genes detected by ML include: Nuclear Factor Kappa B Subunit 1 (NFKB1), which has been associated with personality disorders (Gescher et al, 2018); Interleukin 4 (IL4), which has been associated with PTSD (Smith et al, 2011); Nuclear Receptor Subfamily 3 Group C Member 1 (NR3C1), previously associated with emotion dysregulation, psychopathology (Cicchetti & Handley, 2017), depression (Borçoi et al, 2020;Efstathopoulos et al, 2018), and risk of PTSD (Schechter et al, 2015;Vukojevic et al, 2014); and Nuclear Factor Of Activated T Cells 1 (NFATC1), which has been previously associated with PTSD and depression (Kuan et al, 2017). It is clear from the literature that GRRN genes play a crucial role in mediating the stress response, and many genes identified here by our ML analyses have been previously associated with traumatic stress and stress-related psychopathology.…”

Section: Discussionmentioning

confidence: 99%

The impact of psychopathology, social adversity and stress-relevant DNA methylation on prospective risk for post-traumatic stress: A machine learning approach

Wani

Aiello

Kim

et al. 2021

Journal of Affective Disorders

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Background:A range of factors have been identified that contribute to greater incidence, severity, and prolonged course of post-traumatic stress disorder (PTSD), including: comorbid and/or prior psychopathology; social adversity such as low socioeconomic position, perceived discrimination, and isolation; and biological factors such as genomic variation at glucocorticoid receptor regulatory network (GRRN) genes. This complex etiology and clinical course make identification of people at higher risk of PTSD challenging. Here we leverage machine learning (ML) approaches to identify a core set of factors that may together predispose persons to PTSD. Methods:We used multiple ML approaches to assess the relationship among DNA methylation (DNAm) at GRRN genes, prior psychopathology, social adversity, and prospective risk for PTS severity (PTSS). Results:ML models predicted prospective risk of PTSS with high accuracy. The Gradient Boost approach was the top-performing model with mean absolute error of 0.135, mean square error of 0.047, root mean square error of 0.217, and R 2 of 95.29%. Prior PTSS ranked highest in predicting the prospective risk of PTSS, accounting for >88% of the prediction. The top ranked GRRN CpG site was cg05616442, in AKT1, and the top ranked social adversity feature was loneliness. Conclusion:. CC-BY-NC-ND 4.0 International license available under a (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made

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Section: Discussionmentioning

confidence: 99%

The impact of psychopathology, social adversity and stress-relevant DNA methylation on prospective risk for post-traumatic stress: A machine learning approach

Wani

Aiello

Kim

et al. 2021

Journal of Affective Disorders

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“…33,34 Borçói et al found a prevalence ratio of 2.69 (95% CI 1.62-4.46) for being a current smoker, among individuals with depressive disorder in a sample at a primary care service in a Brazilian municipality (Alegre, Espírito Santo). 33 We found lower odds of obesity among individuals with lifetime histories of major depression. The results in the medical literature regarding this association are divergent, with positive results, 35,36 negative results [37][38][39] and inverse associations.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular risk factors and major depressive disorder: a cross-sectional study in São Paulo, Brazil

et al. 2021

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BACKGROUND: Cardiovascular risk factors can mediate the association between depression and cardiovascular diseases. OBJECTIVE: To evaluate cardiovascular risk factors in adult individuals with and without histories of major depression in the metropolitan region of São Paulo, Brazil. DESIGN AND SETTING: Cross-sectional study in São Paulo (SP), Brazil.METHODS: This study evaluated 423 individuals without any lifetime diagnosis of major depression and 203 individuals with a previous diagnosis of major depression (n = 626). The participants underwent a psychiatric evaluation using a structured clinical interview (SCID-1), an anthropometric evaluation and a clinical evaluation that included blood pressure measurement and assessment of fasting blood glucose, lipid profile and physical activity levels. RESULTS: Individuals with histories of major depression were more likely to be female (P < 0.0001). Individuals with lifetime diagnoses of major depression were more likely to be current smokers (odds ratio, OR 1.61; 95% confidence interval, CI 1.01-2.59) and to have diabetes (OR 1.79; 95% CI 1.01-3.21); and less likely to be obese (OR 0.58; 95% CI 0.35-0.94). CONCLUSION: Individuals with major depression had higher odds of presenting tobacco smoking and diabetes, and lower odds of being obese. Healthcare professionals need to be aware of this, so as to increase the rates of diagnosis and treatment in this population.

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“…Estudos atuais têm se concentrado em evidências de que os mecanismos epigenéticos desempenham um papel fundamental no processo de envelhecimento biológico, na busca de marcadores para doenças complexas e nos efeitos transgeracionais em pais que foram expostos em determinadas condições ambientais (BORÇOI et al, 2020;LOCKE et al, 2019;RYAN et al, 2019;UNNIKRISHNAN et al, 2019).…”

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Genômica E Os Sequenciadores De Próxima Geração

Doblas¹,

Louro²

2021

Avanços Metodológicos Em Biologia Molecular E Biotecnologia

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Direitos para esta edição cedidos à Atena Editora pelos autores. Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0).O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais. Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação com base em critérios de neutralidade e imparcialidade acadêmica.A Atena Editora é comprometida em garantir a integridade editorial em todas as etapas do processo de publicação, evitando plágio, dados ou resultados fraudulentos e impedindo que interesses financeiros comprometam os padrões éticos da publicação. Situações suspeitas de má conduta científica serão investigadas sob o mais alto padrão de rigor acadêmico e ético.

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Risk factors for depression in adults: NR3C1 DNA methylation and lifestyle association

Cited by 22 publications

References 66 publications

The impact of psychopathology, social adversity and stress-relevant DNA methylation on prospective risk for post-traumatic stress: A machine learning approach

The impact of psychopathology, social adversity and stress-relevant DNA methylation on prospective risk for post-traumatic stress: A machine learning approach

Cardiovascular risk factors and major depressive disorder: a cross-sectional study in São Paulo, Brazil

Genômica E Os Sequenciadores De Próxima Geração

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