Risk factors for deep vein thrombosis and pulmonary embolism during pregnancy or post partum: A population-based, case-control study

Danilenko-Dixon, Diana R.; Heit, John A.; Silverstein, Marc D.; Yawn, Barbara P.; Petterson, Tanya M.; Lohse, Christine M.; Melton, L. Joseph

doi:10.1067/mob.2001.107919

Cited by 198 publications

(98 citation statements)

References 20 publications

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“…Danilenko-Dixon et al 15 found no association between BW as a linear variable and the risk of postpartum VTE. However, the power of this case-control study was limited (56 cases), a nonlinear association was not tested, and mothers of preterm newborns were not excluded.…”

Section: Discussionmentioning

confidence: 99%

Association Between Newborn Birth Weight and the Risk of Postpartum Maternal Venous Thromboembolism

et al. 2015

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Background-Postpartum venous thromboembolism (VTE) is a potentially fatal and preventable event leading to substantial short-and long-term morbidity. We sought to evaluate whether the delivery of term newborns of low or high birth weight was associated with greater risks of VTE. Methods and Results-In a population-based case-control study conducted in Washington State from 1987 through 2011, cases of hospitalized VTE within 3 months of delivery were identified by using selected International Classification of Diseases, Ninth Revision, Clinical Modification codes. Controls were randomly selected postpartum women without VTE, matched on birth year. Birth weight and other maternal and pregnancy characteristics were extracted from birth certificate data. Among term live singleton deliveries, we compared the risk of VTE for mothers of newborns of low and high birth weights (<2500 g and >4000 g, respectively) versus mothers of newborns of normal birth weight (2500-4000 g). Logistic regression models were adjusted for maternal age, race, education, body mass index, parity, delivery methods, gestational length, smoking, gestational diabetes mellitus, and preeclampsia. Patients with VTE (n=547) were older, had a higher body mass index, and experienced more pregnancy-related complications than controls (n=9482).In comparison with mothers of newborns with normal birth weight, mothers of newborns with low birth weight had a 3-fold increased risk of VTE, which persisted after multivariable adjustment (odds ratio, 2.98; 95% confidence interval, 1.80-4.93). Mothers of newborns with high birth weight had only a slightly increased risk of VTE, which was attenuated after multivariable adjustment (odds ratio, 1.26; 95% confidence interval, 0.99-1.61). Conclusions-The delivery of a newborn with low birth weight is associated with a 3-fold increased risk of maternal postpartum VTE. This should be considered when assessing VTE risk at delivery.

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Section: Discussionmentioning

confidence: 99%

Association Between Newborn Birth Weight and the Risk of Postpartum Maternal Venous Thromboembolism

et al. 2015

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“…The risk during the postpartum period is about fivefold higher than the risk during pregnancy [176]. Prior superficial vein thrombosis is an independent risk factor for VTE during pregnancy or postpartum [182,183].…”

Section: Questionsmentioning

confidence: 99%

Epidemiology of venous thromboembolism

Ashrani¹,

Heit²

2008

Venous Thromboembolism in Advanced Disease

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Venous thromboembolism (VTE) is categorized by the U.S. Surgeon General as a major public health problem. VTE is relatively common and associated with reduced survival and substantial health-care costs, and recurs frequently. VTE is a complex (multifactorial) disease, involving interactions between acquired or inherited predispositions to thrombosis and VTE risk factors, including increasing patient age and obesity, hospitalization for surgery or acute illness, nursing-home confinement, active cancer, trauma or fracture, immobility or leg paresis, superficial vein thrombosis, and, in women, pregnancy and puerperium, oral contraception, and hormone therapy. Although independent VTE risk factors and predictors of VTE recurrence have been identified, and effective primary and secondary prophylaxis is available, the occurrence of VTE seems to be relatively constant, or even increasing.

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“…Although the incidence of PE in individuals older than age 45 is higher in men than in women, numerous studies have shown that in young adults, women have a significantly higher rate of PE [29]. Pregnancy and the postpartum period are well-known risk factors for PE [63], with the risk of PE five times higher in pregnant compared with nonpregnant women [34]. During the postpartum period, there is an even greater risk of thrombosis than during pregnancy [29].…”

Section: Pregnancymentioning

confidence: 99%