“…This could mean that, with experience, surgeons identified risks more rapidly during LC, while surgeons less skilled in laparoscopic techniques recognized that the laparoscopic approach might be technically too demanding in difficult cases of AC and preferred conversion to a primary open approach [3,[11][12][13][14]. Local disease-related factors, such as gangrenous cholecystitis or coexistent CBDS, were major predictive factors of conversion, in agreement with previous reports [13,14]. Surprisingly, women under the age of 65 years were less at risk of requiring conversion (p \ 0.001).…”