Risk Factors for Contracting Invasive Meningococcal Disease and Related Mortality: A Systematic Literature Review and Meta-analysis

Dubey, Himanshu; Oster, Philipp; Fazeli, Mir Sohail; Guedes, Sandra; Serafini, Paul; Leung, Lisa; Amiche, Amine

doi:10.1016/j.ijid.2022.03.032

Cited by 9 publications

(8 citation statements)

References 57 publications

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“…This suggests marked differences in level of education and socioeconomic disadvantage. Behavioural determinants for IMD have been linked to exposure to passive smoke, crowded living conditions, younger age, and low household income [ 35 – 37 ]. The ‘B Part of It’ RCT, from which we drew our study population, found that similar behavioural risk factors were also associated with carriage including current upper respiratory tract infection, cigarette smoking, attending pubs or clubs, and intimate kissing [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Geographical distribution of invasive meningococcal disease and carriage: A spatial analysis

Milazzo,

McMillan,

Giles

et al. 2024

Epidemiol. Infect.

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Little information exists concerning the spatial relationship between invasive meningococcal disease (IMD) cases and Neisseria meningitidis (N. meningitidis) carriage. The aim of this study was to examine whether there is a relationship between IMD and asymptomatic oropharyngeal carriage of meningococci by spatial analysis to identify the distribution and patterns of cases and carriage in South Australia (SA). Carriage data geocoded to participants' residential addresses and meningococcal case notifications using Postal Area (POA) centroids were used to analyse spatial distribution by disease-and non-disease-associated genogroups, as well as overall from 2017 to 2020. The majority of IMD cases were genogroup B with the overall highest incidence of cases reported in infants, young children, and adolescents. We found no clear spatial association between N. meningitidis carriage and IMD cases. However, analyses using carriage and case genogroups showed differences in the spatial distribution between metropolitan and regional areas. Regional areas had a higher rate of IMD cases and carriage prevalence. While no clear relationship between cases and carriage was evident in the spatial analysis, the higher rates of both carriage and disease in regional areas highlight the need to maintain high vaccine coverage outside of the well-resourced metropolitan area.

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Section: Discussionmentioning

confidence: 99%

Geographical distribution of invasive meningococcal disease and carriage: A spatial analysis

Milazzo,

McMillan,

Giles

et al. 2024

Epidemiol. Infect.

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“…HIV infection confers a modest increased risk of IMD compared with other conditions such as complement deficiency asplenia/splenic dysfunction [15]. Recent studies have identified this increased risk even in well‐controlled HIV [13]. Consequently, meningococcal vaccines are recommended for PLHIV in some countries such as the USA, Ireland, Italy, Australia, and Luxembourg [14, 15].…”

Section: Discussionmentioning

confidence: 99%

“…We have previously shown that people living with HIV, including those receiving effective antiretroviral therapy (ART), have an increased risk of IMD compared with the general population [12]. Similarly, a recent systematic review and meta‐analysis of risk factors for IMD showed an increased risk in people living with HIV (PLHIV) versus those without HIV, which was nearly three‐fold higher in adults aged 25–44 years [13]. In the USA and several European countries, PLHIV are included in the increased high‐risk groups for IMD for which vaccination against meningococcus is recommended [14, 15].…”

Section: Introductionmentioning

confidence: 99%

Propositive follow‐up: Long‐term immune responses to the 4CMenB and MenACWY vaccines in people living with HIV

San Francisco Ramos,

Isitt,

Athaide

et al. 2023

HIV Medicine

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BackgroundPeople living with HIV have an increased risk of meningococcal disease. The Propositive trial evaluated co‐administration of two doses of a four‐component recombinant protein‐based MenB vaccine (4CMenB) and a quadrivalent conjugate polysaccharide MenACWY vaccine (MenACWY‐CRM197) given 1 month apart in people with HIV. The follow‐up trial assessed the immunogenicity of these vaccines at 1.5 and 2.5 years after primary vaccination.MethodsParticipants who completed the parent Propositive trial were invited to the follow‐up study. Immunogenicity analysis was performed at 18 and 30 months after primary vaccination. Primary outcome measures were serum bactericidal antibody (SBA) geometric mean titres (GMTs) against three MenB reference strains and the proportion of participants maintaining a protective SBA titre of ≥4 at 18 and 30 months. Secondary outcome measures were SBA GMTs against MenA, C, W, and Y serogroups and the proportion of participants maintaining a protective SBA titre of ≥8 at 18 and 30 months. The trial is registered with Clinicaltrials.gov (NCT042394300).ResultsA total of 40 participants aged 22–47 years were enrolled. Geometric mean titres waned by 18 and 30 months but remained higher than pre‐vaccination for all MenB strains and MenA, C, W, and Y. In total, 75%–85% of participants retained protective SBA titres by 30 months against individual MenB strains, whereas 68.8% of patients retained protective antibody titres against all three MenB strains. Antibodies against MenC waned more rapidly than did those against MenA, W, and Y. The proportion of participants with protective titres against MenC at 30 months was also lower (46.9%) than that with protective titres against MenA (87.5%), W (78.1%), and Y (87.5%).ConclusionsImmune responses against MenB in our cohort of people living with HIV at 2.5 years of follow‐up were reassuring, with 68.8% of participants retaining protection against all three reference strains. However, responses against MenC were lower than those against MenA, W, and Y serogroups.

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“…So far, twelve serogroups have been identified, six of which (A, B, C, W, X, and Y) are responsible for almost all cases of invasive meningococcal disease (IMD) [ 1 - 2 ]. A recent meta-analysis [ 2 ] quantified the significant risk of developing IMD in the presence of some factors, such as HIV infection, active or passive smoking, and crowded living environments. A Chinese meta-analysis recently estimated an annual incidence of 0.66-2.30 per 100,000 habitants [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Neisseria meningitidis is a Gram-negative diplococcus that may be found as a benign commensal bacterium in the human nasopharynx in approximately 10% of healthy individuals [1][2][3]. In some cases, it can cause invasive diseases, such as bacteremia, meningitis, or septic arthritis.…”

Section: Introductionmentioning

confidence: 99%

Meningococcal Septic Oligoarthritis: An Unusual Presentation Revealing Concurrent Multiple Myeloma

Rocha,

Silva,

Miranda

et al. 2023

Cureus

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Meningococcal invasive disease is rare in immunocompetent hosts but may occur in patients with risk factors. Septic arthritis is an uncommon form of presentation and is usually due to surgical colonization or hematogenous dissemination. We present a case of a 73-year-old woman, who recently underwent knee replacement surgery, presenting with right knee and left shoulder pain, swelling, and reduced range of motion. Antibiotic therapy was promptly initiated, and the identification of invasive meningococcal disease with septic arthritis was possible through blood cultures and synovial fluid analysis.

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Risk Factors for Contracting Invasive Meningococcal Disease and Related Mortality: A Systematic Literature Review and Meta-analysis

Cited by 9 publications

References 57 publications

Geographical distribution of invasive meningococcal disease and carriage: A spatial analysis

Geographical distribution of invasive meningococcal disease and carriage: A spatial analysis

Propositive follow‐up: Long‐term immune responses to the 4CMenB and MenACWY vaccines in people living with HIV

Meningococcal Septic Oligoarthritis: An Unusual Presentation Revealing Concurrent Multiple Myeloma

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