Risk Factors for Cerebral Palsy in Moldova

Gincota, Ecaterina Bufteac; Jahnsen, Reidun; Spinei, Larisa; Andersen, Guro L.

doi:10.3390/medicina57060540

Cited by 6 publications

(8 citation statements)

References 24 publications

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“…The cause of preterm births can also be examined as a subject of a separate study. Gincota et al [ 16 ] reported in their study that low socio-economic status was associated with CP. In our study, according to the mothers’ declarations, the income levels of these families were low at a rate of 73.3% and at a moderate level with a rate of 24.8%, and low socioeconomic status was remarkable in terms of CP risk factor.…”

Section: Discussionmentioning

confidence: 99%

Etiological risk factors in children with cerebral palsy

et al. 2023

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To evaluate the etiological risk factors of cerebral palsy, especially the preventable ones. The study was carried out with the mothers of 210 children with cerebral palsy (CP) registered in Mardin Guidance and Research Center between February and May 2022. The data form prepared by the researchers was applied to the mothers by face-to-face interview technique. The data form consisted of 29 questions including sociodemographic characteristics of the child and mother, risk factors for CP, and secondary medical problems of the child. Of the 210 patients included in the study, 43.3% (91) were female and 56.7% (119) were male. The mean age of the children was 67.4 (SD = 50.6) weeks, and 73.3% of children were premature. The number of children with a birth weight below 2500 g was 48.1% (101). The mean birth weight was 2472.5 (SD = 871.8) g. The children with another disabled sibling consisted 6.2% of the population. Among the mothers, 41.9% stated that they were illiterate and 73.3% stated that their income status was low. The rate of the parents that were related to each other was 51%. In our study, it was noteworthy that most of the children were premature, had low birth weight, more than half of them had parents who were relatives, the education level of the mothers was low, the socioeconomic status of most of the families was low, and most of these risk factors were preventable.

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Section: Discussionmentioning

confidence: 99%

Etiological risk factors in children with cerebral palsy

et al. 2023

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“…Parental risk factors, primarily reported on the maternal side, include hypertension, 12 diabetes mellitus, 10,12 infection or chorioamnionitis, 12 alcohol consumption during pregnancy, 13 parent aged older than 35 years, 13 preeclampsia, 10 prolonged rupture of membranes, 10 and birth by Cesarean section. 8 Infant risk factors are low birthweight, 11,12 neonatal infections, 10 being born preterm, 11 malformations, 8,10 being born small for gestational age, 8,13 admission to a neonatal intensive care unit, 8 meconium aspiration, 10 birth asphyxia, 12 respiratory distress syndrome, 9 multiple gestation, 12,13 intraventricular hemorrhage (IVH), 10 neonatal encephalopathy, 10,12 hyperbilirubinemia, 10,13 and male sex. 13 Additionally, the research methods used varied, with most studies using relatively small sample sizes.…”

Section: Risk Factors For Cerebral Palsy In Children In Taiwanmentioning

confidence: 99%

“…Systematic reviews, meta-analyses, and individual studies investigated the potential risk factors of CP, [8][9][10][11][12][13] but a consensus has yet to be reached. Generally, risk factors can be…”

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confidence: 99%

Risk factors for cerebral palsy in children in Taiwan

Chen,

Huang,

Wei

et al. 2024

Develop Med Child Neuro

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AimTo determine the significant risk factors of cerebral palsy (CP) in Taiwanese children and the associations between infant‐related and parent‐related factors.MethodData from 1 459 093 infants and their parents in Taiwan's national databases collected between 2009 and 2016 were used. The cohort with CP included children diagnosed with CP between birth and age 3 years; a total of 3254 children with CP were included in the final analysis. Hierarchical logistic regression models were used to estimate the odds ratio for the risk factors of CP.ResultsThe hierarchical logistic regression models indicated that significant risk factors associated with CP are suburban location, low income, maternal and paternal diabetes mellitus, paternal substance abuse, paternal seizure disorder, male sex, birth by Cesarean section, singleton birth, low birthweight, being born extremely and very preterm, intraventricular hemorrhage, and periventricular leukomalacia, as well as tube feeding, ventilator use, and dopamine administration within 6 months of age.InterpretationIn addition to common maternal and infant risk factors, we identified significant paternal risk factors associated with CP, including diabetes mellitus, seizure disorder, and substance abuse. The combination of maternal, paternal, and infant risk factors in CP holds great promise for early identification and intervention.

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“…In a study conducted in Moldova, a low-income country, among 351 individuals with CP, several significant risk factors were identified. These included maternal alcohol consumption during pregnancy [odds ratio (OR) 1.7, P=0.002], maternal hypertension (OR 2.0, P<0.001), living in rural areas (OR 1.6, P<0.001), maternal age of more than 35 years old (OR 0.6, P=0.001), maternal epilepsy (OR 4.3, P<0.001), breech delivery (OR 3.1, P=0.001), home births (OR 6.3, P=0.001), umbilical cord around neck (OR 2.2, P<0.001), assisted vaginal delivery (OR 3.1, P<0.001), male gender (OR 1.3, P<0.001), small gestational age (SGA) (OR 1.3, P=0.027), multiple gestations (OR 1.7, P<0.001) and hyperbilirubinemia (OR 4.5, P<0.001) ( 3 ). CP classification, proposed by Ingram and Hagberg, encompasses types of neurological syndromes, affected sites, and severity of symptoms.…”

Section: Introductionmentioning

confidence: 99%

Nutritional status as predictors for quality of life among caregivers of children with severe cerebral palsy

Kamal,

Hamzaid,

Kamaralzaman

et al. 2023

Transl Pediatr

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Background Individuals with severe cerebral palsy (CP) often experience various health issues, including feeding difficulties, which can adversely affect their nutritional status and caregivers’ quality of life, e.g., more time spent for feeding rather than own selfcare. This study aimed to determine the prevalence of poor nutritional status among individuals with severe CP and explore its role as predictors for caregivers’ quality of life. Methods This cross-sectional study was conducted in a government hospital (Cheras Rehabilitation Hospital), Community-Based Rehabilitation (CBR) Program, and Spastic Centre [non-profit organization (NGO)] in Klang Valley, Malaysia. Seventy-one participants with Gross Motor Function Classification System (GMFCS) level IV and V were recruited. Sociodemographic data, health-associated data, and anthropometric data were collected. Caregivers’ quality of life was assessed using the Pediatric Quality of Life Inventory (PedsQL) CP module version 3.0 which included domains such as Movement and Balance, Eating Activities, and School Activities. Results Most participants were males (60.6%), with 61 classified as level IV in the GMFCS classification. According to the Eating and Drinking Ability Classification System (EDACS), 59 children were at level IV. In total, 40.8% were underweight according to CP growth chart and 49.3% had mid-upper arm circumference (MUAC) readings below the 5 th percentile. The lowest scores in the PedsQL CP module version 3.0 were observed in the Daily Activities (5.34±10.87), and School Activities domains (8.15±18.65). Sociodemographic and anthropometric data, including body mass index (BMI)-for-age, MUAC, body fat, triceps, and subscapular skinfold measurement, were predictors for the School Activities domain [F (11, 44)=3.981, P<0.005, R 2 =0.499]. Conclusions Poor nutritional status in individuals with severe CP has been shown to negatively impact caregivers’ quality of life. Therefore, a multidisciplinary approach involving nutritional intervention is essential to improve dietary provision and the nutritional status of children with CP.

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Risk Factors for Cerebral Palsy in Moldova

Cited by 6 publications

References 24 publications

Etiological risk factors in children with cerebral palsy

Etiological risk factors in children with cerebral palsy

Risk factors for cerebral palsy in children in Taiwan

Nutritional status as predictors for quality of life among caregivers of children with severe cerebral palsy

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