Risk factors for cerebral palsy in children born at term

Himmelmann, Kate; Ahlin, Kristina; Jacobsson, Bo; Cans, Christine; Thorsen, Poul

doi:10.1111/j.1600-0412.2011.01217.x

Cited by 89 publications

(45 citation statements)

References 76 publications

(89 reference statements)

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“…9,10,16,17 We did not find the controversial association of delivery induction with CP. 18,19 In term deliveries, low Apgar score at 5 and 10 minutes frequently reflects perinatal asphyxia and acidosis, and predicts neonatal morbidity and mortality.…”

Section: Figurementioning

confidence: 89%

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Asphyxia, Neurologic Morbidity, and Perinatal Mortality in Early-Term and Postterm Birth

Seikku¹,

Gissler

Andersson

et al. 2016

Pediatrics

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Section: Figurementioning

confidence: 89%

“…We found a decreasing incidence of CP in Finland during our study period, contrary to a recent finding of an unchanging overall worldwide prevalence of CP. 17 The increased incidences of epilepsy, intellectual disability, and sensorineural defects may be explainable by improved diagnostics and advanced datacollecting systems.…”

Section: Figurementioning

confidence: 99%

Asphyxia, Neurologic Morbidity, and Perinatal Mortality in Early-Term and Postterm Birth

Seikku¹,

Gissler

Andersson

et al. 2016

Pediatrics

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“…Basal ganglia injury after hypoxia ischaemia (HI) at term remains a major contributor to poor neurodevelopmental outcomes such as cerebral palsy, learning disability and epilepsy 1, 2 . Basal ganglia injury occurs in approximately 25% of cases of encephalopathy at term and is strongly associated with poor neurophysiological outcomes, such as increased severity of neonatal seizures 3 , and discontinuity of electroencephalographic activity 4, 5 .…”

Section: Introductionmentioning

confidence: 99%

Connexin hemichannel blockade improves survival of striatal GABA-ergic neurons after global cerebral ischaemia in term-equivalent fetal sheep

Galinsky

Davidson

Lear

et al. 2017

Sci Rep

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Basal ganglia injury at term remains a major cause of disability, such as cerebral palsy. In this study we tested the hypotheses that blockade of astrocytic connexin hemichannels with a mimetic peptide would improve survival of striatal phenotypic neurons after global cerebral ischaemia in term-equivalent fetal sheep, and that neuronal survival would be associated with electrophysiological recovery. Fetal sheep (0.85 gestation) were randomly assigned to receive a short or long (1 or 25 h) intracerebroventricular infusion of a mimetic peptide or vehicle, starting 90 minutes after 30 minutes of cerebral ischaemia. Sheep were killed 7 days after ischaemia. Cerebral ischaemia was associated with reduced numbers of calbindin-28k, calretinin, parvalbumin and GAD positive striatal neurons (P < 0.05 ischaemia + vehicle, n = 6 vs. sham ischaemia, n = 6) but not ChAT or nNOS positive neurons. Short infusion of peptide (n = 6) did not significantly improve survival of any striatal phenotype. Long infusion of peptide (n = 6) was associated with increased survival of calbindin-28k, calretinin, parvalbumin and GAD positive neurons (P < 0.05 vs. ischaemia + vehicle). Neurophysiological recovery was associated with improved survival of calbindin-28k, calretinin and parvalbumin positive striatal neurons (P < 0.05 for all). In conclusion, connexin hemichannel blockade after cerebral ischaemia in term-equivalent fetal sheep improves survival of striatal GABA-ergic neurons.

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“…Population-based surveillance programmes are considered the criterion standard for describing its changing birth and childhood prevalence and characteristics. 1,2 The earliest CP registers and surveillance systems have reported on trends since the 1950s. 1,3 However, the number of registers and population-based surveillance systems (hereafter referred to as 'surveillance programmes') is increasing 3 and currently nearly 40 exist worldwide.…”

mentioning

confidence: 99%

An international survey of cerebral palsy registers and surveillance systems

2016

Dev Med Child Neurol

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AIM-To describe cerebral palsy (CP) surveillance programmes and identify similarities and differences in governance and funding, aims and scope, definition, inclusion/exclusion criteria, ascertainment and data collection, to enhance the potential for research collaboration.METHOD-Representatives from 38 CP surveillance programmes were invited to participate in an online survey and submit their data collection forms. Descriptive statistics were used to summarize information submitted.RESULTS-Twenty-seven surveillance programmes participated (25 functioning registers, two closed owing to lack of funding). Their aims spanned five domains: resource for CP research, surveillance, aetiology/prevention, service planning, and information provision (in descending order of frequency). Published definitions guided decision making for the definition of CP and case eligibility for most programmes. Consent, case identification, and data collection methods varied widely. Ten key data items were collected by all programmes and a further seven by at least 80% of programmes. All programmes reported an interest in research collaboration.INTERPRETATION-Despite variability in methodologies, similarities exist across programmes in terms of their aims, definitions, and data collected. These findings will facilitate harmonization of data and collaborative research efforts, which are so necessary on account of the heterogeneity and relatively low prevalence of CP.Correspondence to Shona Goldsmith, Cerebral Palsy Alliance, PO Box 6427, Frenchs Forest, NSW 2086, Australia. sgoldsmith@cerebralpalsy.org.au. A list of contributors is given in Appendix S1 (online supporting information). SUPPORTING INFORMATIONAdditional supporting information may be found in the online version of this article: Appendix S1: List of contributors. The purpose of this survey was to describe CP surveillance programmes and identify similarities and differences across topics of importance for the relevance and sustainability of, and collaboration between, surveillance programmes. It is anticipated that results will (1) encourage and inform those establishing new programmes about the methods and data items collected by existing programmes; (2) inform health professionals and researchers of the existence of national and international surveillance programmes and the potential for population-based research and data linkages; and (3) assist existing surveillance programmes to investigate the potential for future collaborations. HHS Public Access METHODRepresentatives from 38 surveillance programmes were contacted by e-mail and invited to participate in the online survey. Surveillance programmes were identified by the study authors, and all participants were encouraged to forward the survey link to any other known surveillance programmes.The survey, developed and constructed by the study authors, was available online via 'Survey Monkey' (https://www.surveymonkey.com) for 4 weeks in June to July 2014. Seventy-one questions related to issues of governance and fundin...

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Risk factors for cerebral palsy in children born at term

Cited by 89 publications

References 76 publications

Asphyxia, Neurologic Morbidity, and Perinatal Mortality in Early-Term and Postterm Birth

Asphyxia, Neurologic Morbidity, and Perinatal Mortality in Early-Term and Postterm Birth

Connexin hemichannel blockade improves survival of striatal GABA-ergic neurons after global cerebral ischaemia in term-equivalent fetal sheep

An international survey of cerebral palsy registers and surveillance systems

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