Risk factors for central venous catheter-related thrombosis in hospitalized children: a single-center a retrospective cohort study

Abstract

Background: This study aimed to explore the risk factors of catheter-related thrombosis (CRT) in children in Southwest China who underwent central venous catheter (CVC) insertion.Methods: An observational cohort study was conducted at a single tertiary center in southwest China between November 2019 and February 2020. All patients who received a CVC were enrolled and Doppler-ultrasound examination was performed weekly until CVC removal. All patients in this study were hospitalized and were observed and followed up in this hospital. Patient demographics, medication, biochemical indexes, catheter maintenance practice, activities after CVC placement data were analyzed. The Kaplan-Meier method was used to calculate the incidence of CRT, and the Cox regression model was used to analyze the factors influencing CRT.Results: A total of 594 children were included in the study, and the median indwelling time was 10 days, with the shortest being 1 day and the longest 60 days. The overall incidence of CRT was 26.60% (158/594), the 15-day cumulative incidence rate was 30.81%, and the 45-day cumulative incidence rate was 46.27%. After 45 days, the incidence of CRT further increased. Age <12 months [hazard ratio (HR), 1.654; 95%

Risk factors and incidence of central venous access device-related thrombosis in hospitalized children: a systematic review and meta-analysis

“…The prevalence of CRT in children varies significantly by country, age, disease, and medical institution, ranging from 2 to 81%, 4,[8][9][10] while in Chinese children without prophylactic treatment ranges from 20 to 66%. 11,12 CRT has no obvious clinical symptoms in the early stage, but it may still cause serious side effects, not only increasing the patient pain and medical costs but also delaying treatment timing, affecting prognosis and quality of life, and in severe cases, may even lead to thromboembolism, endangering life. [13][14][15] Identifying risk factors and incidence of CRT facilitates clinical practitioners in the early identification of high-risk patients, designing specific preventive strategies, treatment regimens, and management plans, thereby effectively reducing the incidence of CRT in hospitalized children and alleviating unnecessary patient suffering.…”

Study on PTFE Superhydrophobic Coating Modified by IC@dMSNs and its Enhanced Antibacterial Effect

“…But once a catheter infection occurs, it is necessary to remove the catheter, conduct catheter end and blood culture to determine the source of infection and bacterial species, use effective antibiotics, and reinsert the catheter in another location. Most of the bacteria associated with catheter infections are super bacteria that are resistant to most antibiotics (10), causing great harm to critically ill patients, exacerbating their condition, increasing treatment costs, and increasing the risk of other complications (10)(11)(12).…”