Risk factors for candidemia with non-albicans Candida spp. in intensive care unit patients with end-stage renal disease on chronic hemodialysis

Abstract

Central venous catheterization was the only factor significantly associated with BSI due to NAC in ICU patients with end-stage renal disease.

An alarming rise of non-albicans Candida species and uncommon yeasts in the clinical samples; a combination of various molecular techniques for identification of etiologic agents

“…Interestingly, Pakshir et al (29) showed C. parapsilosis as the most prevalent Candida species collected from fingernails infection (45.3%), even higher than C. albicans (23.7%). Non-albicans Candida infections may have more incidence among patients with allogeneic hepatocyte transplantation, neutropenia, hematologic malignancies, and severe immune suppression (30,31) however, in our study, there was no difference in neutropenia and malignancies between patients with C. albicans or NAC infections, and diabetes mellitus and pregnancy were the most risk factors.…”

Creation and assessment of a clinical predictive model for candidaemia in patients with candiduria

“…Although Candida species in the urine rarely disseminates into the bloodstream, candiduria has a positive association with candidaemia . Prior investigations on the risk factors for candidaemia generally focus on patients in the intensive care units or as a comparison between C albicans vs non‐ albicans species infection . To the best of our knowledge, this is the first study to assess potential patient factors that influence the risk of concurrent candidaemia with candiduria.…”

Risk factors for health care–associated infection in hospitalized adults: Systematic review and meta-analysis

“…In the cohort studies, the observed extrinsic RFs were central venous catheter (CVC) placement, 23,25,[50][51][52][53] ICU admission, [54][55][56][57][58] duration of surgery, 13,17,20,24 steroid use, 13,15,59 previous antibiotic use, 55,60 exposure to cephalosporins before the first episode of infection, 58,61 number of administered antibiotics, 53,62 antimicrobial therapy within 90 days, 63 reoperation, 20,64 transfusion, 50,56,64 invasive mechanical ventilation (IMV), 50,52,65 hospitalization time, 66,67 and a high score on the Acute Physiology and Chronic Health Disease Classification System II. 14,55 Other less frequent extrinsic RFs were found ( Supplementary Table S1).…”