Risk factors for bleeding in patients receiving fondaparinux after colorectal cancer surgery

Pak, Jongsung; Ikeda, Masataka; Uemura, Mamoru; Miyake, Masakazu; Nishikawa, Kazuhiro; Miyamoto, Atsushi; Miyazaki, Michihiko; Hirao, Motohiro; Nakamori, Shoji; Sekimoto, Mitsugu

doi:10.23922/jarc.2017-022

Cited by 5 publications

(4 citation statements)

References 14 publications

(11 reference statements)

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“…These changes can lead to several postoperative complications, such as VTE and bleeding. It has been reported that VTE and bleeding at or greater than CD grade III after curative resection of primary colorectal cancer occurs at rates of 0 to 0.16% and 0.2 to 0.81%, respectively [22][23][24]. Compared with these data, in the present study, VTE and bleeding events more frequently occurred (Table 4).…”

Section: Discussioncontrasting

confidence: 44%

Impact of the preoperative prognostic nutritional index as a predictor for postoperative complications after resection of locally recurrent rectal cancer

Paku

Uemura

Kitakaze

et al. 2021

Preprint

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Background Local recurrence is common after curative resections for rectal cancer. Surgical intervention is among the best treatment choices. However, achieving a negative resection margin often requires extensive pelvic organ resections; thus, the postoperative complication rate is quite high. Recent studies have reported that the inflammatory index could predict postoperative complications. This study aimed to validate the correlation between clinical factors, including inflammatory markers, and severe complications after surgery for local recurrent rectal cancer. Methods This retrospective study included 99 patients that underwent radical resections for local recurrences of rectal cancer. Postoperative complications were graded according to the Clavien-Dindo classification. Grades ≥ 3 were defined as severe complications. Risk factors for severe complications were identified with univariate and multivariate logistic regression models and assessed with receiver-operating characteristic curves. Results Severe postoperative complications occurred in 38 patients (38.4%). Analyses of correlations between inflammatory markers and severe postoperative complications revealed that the strongest correlation was found between the prognostic nutrition index and severe postoperative complications. The receiver-operating characteristic analysis showed that the optimal prognostic nutrition index cut-off value was 42.2 (sensitivity: 0.790, specificity: 0.508). In univariate and multivariate analyses, a prognostic nutrition index ≤ 44.2 (Odds ratio: 3.007, 95%CI:1.171–8.255, p = 0.02) and a blood loss ≥ 2850 mL (Odds ratio: 2.545, 95%CI: 1.044–6.367, p = 0.04) were associated with a significantly higher incidence of severe postoperative complications. Conclusions We found that a low preoperative prognostic nutrition index and excessive intraoperative blood loss were risk factors for severe complications after surgery for local recurrent rectal cancer.

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Section: Discussioncontrasting

confidence: 44%

Impact of the preoperative prognostic nutritional index as a predictor for postoperative complications after resection of locally recurrent rectal cancer

Paku

Uemura

Kitakaze

et al. 2021

Preprint

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“…Rectal cancer surgery is frequently associated with complications [15][16][17]. Defecation disorders are among the most frequent complications after rectal cancer surgery.…”

Section: Discussionmentioning

confidence: 99%

Development and evaluation of a Japanese prediction model for low anterior resection syndrome after rectal cancer surgery

et al. 2022

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Background Low anterior resection syndrome (LARS) is the most common complication after rectal cancer resection. We aimed to identify LARS' predictive factors and construct and evaluate a predictive model for LARS. Methods This retrospective study included patients with rectal cancer more than 1 year after laparoscopic or robotic-assisted surgery. We administered a questionnaire to evaluate the degree of LARS. In addition, we examined clinical characteristics with univariate and multivariate analysis to identify predictive factors for major LARS. Finally, we divided the obtained data into a learning set and a validation set. We constructed a predictive model for major LARS using the learning set and assessed the predictive accuracy of the validation set. Results We reviewed 160 patients with rectal cancer and divided them into a learning set (n = 115) and a validation set (n = 45). Univariate and multivariate analyses in the learning set showed that male (odds ratio [OR]: 2.88, 95% confidence interval [95%CI] 1.11–8.09, p = 0.03), age < 75 years (OR: 5.87, 95%CI 1.14–47.25, p = 0.03) and tumors located < 8.5 cm from the AV (OR: 7.20, 95%CI 2.86–19.49, p < 0.01) were significantly related to major LARS. A prediction model based on the patients in the learning set was well-calibrated. Conclusions We found that sex, age, and tumor location were independent predictors of major LARS in Japanese patients that underwent rectal cancer surgery. Our predictive model for major LARS could aid medical staff in educating and treating patients with rectal cancer before and after surgery.

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“…These changes can lead to several postoperative complications, such as VTE and bleeding. It has been reported that VTE and bleeding at or greater than CD grade III after curative resection of primary colorectal cancer occurs at rates of 0 to 0.16% and 0.2 to 0.81%, respectively [ 22 – 24 ]. Compared with these data, in the present study, VTE and bleeding events more frequently occurred (Table 4 ).…”

Section: Discussionmentioning

confidence: 99%

Impact of the preoperative prognostic nutritional index as a predictor for postoperative complications after resection of locally recurrent rectal cancer

et al. 2021

Self Cite

View full text Add to dashboard Cite

Background Local recurrence is common after curative resections for rectal cancer. Surgical intervention is among the best treatment choices. However, achieving a negative resection margin often requires extensive pelvic organ resections; thus, the postoperative complication rate is quite high. Recent studies have reported that the inflammatory index could predict postoperative complications. This study aimed to validate the correlation between clinical factors, including inflammatory markers, and severe complications after surgery for local recurrent rectal cancer. Methods This retrospective study included 99 patients that underwent radical resections for local recurrences of rectal cancer. Postoperative complications were graded according to the Clavien-Dindo classification. Grades ≥3 were defined as severe complications. Risk factors for severe complications were identified with univariate and multivariate logistic regression models and assessed with receiver-operating characteristic curves. Results Severe postoperative complications occurred in 38 patients (38.4%). Analyses of correlations between inflammatory markers and severe postoperative complications revealed that the strongest correlation was found between the prognostic nutrition index and severe postoperative complications. The receiver-operating characteristic analysis showed that the optimal prognostic nutrition index cut-off value was 42.2 (sensitivity: 0.790, specificity: 0.508). In univariate and multivariate analyses, a prognostic nutrition index ≤44.2 (Odds ratio: 3.007, 95%CI:1.171–8.255, p = 0.02) and a blood loss ≥2850 mL (Odds ratio: 2.545, 95%CI: 1.044–6.367, p = 0.04) were associated with a significantly higher incidence of severe postoperative complications. Conclusions We found that a low preoperative prognostic nutrition index and excessive intraoperative blood loss were risk factors for severe complications after surgery for local recurrent rectal cancer.

show abstract

Risk factors for bleeding in patients receiving fondaparinux after colorectal cancer surgery

Cited by 5 publications

References 14 publications

Impact of the preoperative prognostic nutritional index as a predictor for postoperative complications after resection of locally recurrent rectal cancer

Impact of the preoperative prognostic nutritional index as a predictor for postoperative complications after resection of locally recurrent rectal cancer

Development and evaluation of a Japanese prediction model for low anterior resection syndrome after rectal cancer surgery

Impact of the preoperative prognostic nutritional index as a predictor for postoperative complications after resection of locally recurrent rectal cancer

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