Risk factors for basal cell carcinoma: a case-control study

Abstract

A controlled trial was performed with the purpose of investigating which factors could be considered of significant risk for the development of basal cell carcinoma. A total of 259 cases of basal cell carcinoma diagnosed from July 1991 to July 1992 were compared with 518 controls matched for age and sex. All subjects in both groups were white. Protocol data were submitted to statistical analysis by the chi-square test and by multiple conditional logistic regression analysis and the following conclusions were reached: 1) light skin color (types I and II of the Fitzpatrick classification), odds ratio of 2.8; outdoor work under constant sunlight, odds ratio of 5.0; the presence of actinic lesions due to exposure to the sun, odds ratio of 4.9, are risk factors perse. 2) Type III skin in the Fitzpatrick classification only represents a risk factor when the patient reports a history of intense sunburns, but not in the absence of such a history. 3) Sunburns per se do not represent a risk factor althorig the point made in item 2 of these conclusions is valid. 4) Other suspected risk factors whose significance was not confirmed by multiple conditioned logistic regression analysis were: residence in rural areas, light eyes and blond hair color, extent of the awareness of the "sun x skin cancer" relationship, familial occurrence of skin cancer, excessive exposure to the sun, and freckles appearing in childhood.Carcinoma, basal cell, epidemiology.Risk factors.

Comportamento relativo à exposição e proteção solar na população de 15 anos ou mais de 15 capitais brasileiras e Distrito Federal, 2002-2003

“…Como o número de episódios de queimadura por exposição solar na infância parece ser um fator de risco tanto para o câncer de pele melanoma quanto para o não melanoma 4,5,35 , esse grupo etário deveria ser alvo de prevenção primária com relação a esses tipos de câncer. Diversos estudos já foram conduzidos nesse sentido 36,37,38 e espera-se que os resultados, a médio e longo prazo, sejam relevantes.…”

“…Assim sendo, o tipo de câncer a ser desenvolvido parece ser função não somente do tipo de pele e fenótipo 4,5 e da história familiar 6 , mas também do nível de exposição cumulativa, sendo esse úl-timo intimamente relacionado com a latitude na qual se encontra o indivíduo 7 .…”

Topografia do carcinoma basocelular e suas correlações com o gênero, a idade e o padrão histológico: um estudo retrospectivo de 1.042 lesões

“…1 Chronic sun exposure, which differs between men and women, is believed to be the principal cause of these lesions. 2 BCC is more common in individuals over 40 years of age with a history of chronic sun exposure and lesions are often located on the face. [1][2][3] According to some studies, as well as an increase in the incidence of this form of skin cancer, changes have also occurred in the form of presentation of BCC, including an increase in the number of lesions occurring in photo-protected areas of the body and a trend towards a greater occurrence in females; however, few studies have been carried out in Brazil to evaluate these trends.…”

“…2 BCC is more common in individuals over 40 years of age with a history of chronic sun exposure and lesions are often located on the face. [1][2][3] According to some studies, as well as an increase in the incidence of this form of skin cancer, changes have also occurred in the form of presentation of BCC, including an increase in the number of lesions occurring in photo-protected areas of the body and a trend towards a greater occurrence in females; however, few studies have been carried out in Brazil to evaluate these trends. [4][5][6][7][8][9][10][11][12][13][14][15][16] In addition to sun exposure, genetic susceptibility and exposure to other environmental carcinogens are factors that have been related to the etiology of these lesions.…”

“…[4][5][6][7][8][9][10][11][12][13][14][15][16] In addition to sun exposure, genetic susceptibility and exposure to other environmental carcinogens are factors that have been related to the etiology of these lesions. 1,2 Therefore, behavioral and biological differences between male and female patients would be expected to result in different patterns of behavior of BCC. [17][18][19] The present study evaluated the anatomical site of the lesions, their histological type and their correlations with the gender and age of the patients in the study population.…”