Risk Factors for Bacteremia and Predictors of Mortality of Patients with Bloodstream Infection with Methicillin-Resistant Staphylococcus aureus

Bakowski, Elcio; Wey, Sérgio Barsantini; Medeiros, Eduardo Alexandrino

doi:10.3844/ajidsp.2008.262.266

Cited by 3 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a study of 60 MRSA bacteraemia patients and 240 non-infected controls, Bakowski et al . identified severity of illness and use of central venous catheters as independent risk factors for MRSA bacteraemia [20]. In addition, previous surgery was protective against acquiring MRSA bacteraemia.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Risk factors for methicillin-resistantStaphylococcus aureusbacteraemia differ depending on the control group chosen

2013

View full text Add to dashboard Cite

SUMMARY Methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia cause significant morbidity and mortality in hospitalized patients. Using a nested case-control design, 204 MRSA bacteraemia cases were compared to 301 unmatched methicillin-susceptible Staphylococcus aureus (MSSA) bacteraemia controls and were matched 1:2 with non-infected controls. The independent risk factors for MRSA bacteraemia compared to MSSA bacteraemia were older age (P=0·048), major organ transplant during current hospital stay (P=0·016) and quinolone use (P=0·016). Cases were more likely than non-infected controls to have renal failure (P=0·003), cirrhosis (P=0·013), and a central venous catheter (P=0·003) after controlling for other risk factors. This large case-control study made it possible to assess risk factors for MRSA bacteraemia using two sets of controls and showed that risk factors differed greatly depending on the control group chosen. These results confirm the need for careful selection of appropriate control groups and the need to carefully adjust for underlying severity of illness.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Several researchers have attempted to identify predictors of MRSA bacteraemia in hospitals [12, 14–20]. However, the majority of studies were limited by small samples, single-site settings and methodological issues such as inadequate control for severity of illness.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for methicillin-resistantStaphylococcus aureusbacteraemia differ depending on the control group chosen

2013

View full text Add to dashboard Cite

show abstract

Comparative Study of Antibacterial Susceptibility Patterns of the Bacteria Isolated from Patients' Blood Samples over Two Periods

Japoni¹

2011

American Journal of Infectious Diseases

View full text Add to dashboard Cite

Problem statement: Due to continuous changes in the frequencies and antibacterial susceptibility patterns of nosocomial pathogens, periodical surveillance of these fluctuations could help the clinicians to treat hospitalized patients more efficiently whenever empirical therapies need to be considered. This study was conducted to compare the prevalence of the bacteria recovered from bloodstream samples by Bactec 9240, over the two periods of 2001-2004 and 2005-2008 and to evaluate their antibacterial susceptibility patterns. Approach: Totally, 3622 culture positive blood samples were analyzed over the periods. Antibacterial susceptibility patterns of the isolates were determined by standard disk diffusion (Kirby-Bauer) method. The data were compared in terms of quantity and quality of the pathogens and based on their distributions in three main wards. Results: Changes were observed in bacterial composition and frequencies of them, between the two periods. Compared with the first pried, increased frequencies of antibiotic resistant bacteria such as S. aureus, enterococci, acintobacter and pseudomonas were noticed in the second period. Most patients were admitted to pediatrics, followed by adults and neonates wards. Increased antibiotic resistance of the majority of the bacteria in the second period indicates the decreased efficacy of corresponding antibiotics. However, overall efficacy of some antibiotics such as ciprofloxacin and amikacin against Gram positive bacteria preserved. Conclusion: Trend of composition of the bacteria from first to second period could suggest the domination of antibiotic resistant bacteria over the sensitive ones. Appropriate strategies including strict control measures and rational prescription of the effective antibiotics may retard the trend accordingly. Vancomycin and imipenem were the most active antibiotics against Gram positive and negative bacteria. Combination of these two antibiotics is highly recommended for empirical therapy.

show abstract

Institutional and Patient Level Predictors of Multi-Drug Resistant Healthcare-Associated Infections

Pogorzelska¹

2011

View full text Add to dashboard Cite

Risk Factors for Bacteremia and Predictors of Mortality of Patients with Bloodstream Infection with Methicillin-Resistant Staphylococcus aureus

Cited by 3 publications

References 16 publications

Risk factors for methicillin-resistantStaphylococcus aureusbacteraemia differ depending on the control group chosen

Risk factors for methicillin-resistantStaphylococcus aureusbacteraemia differ depending on the control group chosen

Comparative Study of Antibacterial Susceptibility Patterns of the Bacteria Isolated from Patients' Blood Samples over Two Periods

Institutional and Patient Level Predictors of Multi-Drug Resistant Healthcare-Associated Infections

Contact Info

Product

Resources

About