Risk factors for atherosclerosis in patients with chronic kidney disease: recognition and management

Balla, Sudarshan; Nusair, Maen; Alpert, Martin A.

doi:10.1016/j.coph.2012.12.001

Cited by 33 publications

(29 citation statements)

References 29 publications

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“…In particular, accelerated atherosclerosis leading to severe coronary artery disease has been observed in patients with CKD (Baber et al, 2012;Liu et al, 2012). Although the pathophysiology of accelerated atherosclerosis in patients with CKD is not completely understood, accumulation of uremic toxins is partly involved in the condition (Balla et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Indoxyl sulfate stimulates oxidized LDL uptake through up-regulation of CD36 expression in THP-1 macrophages

Cao¹,

Fu²,

Wang³

et al. 2014

JAB

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Section: Introductionmentioning

confidence: 99%

Indoxyl sulfate stimulates oxidized LDL uptake through up-regulation of CD36 expression in THP-1 macrophages

Cao¹,

Fu²,

Wang³

et al. 2014

JAB

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“…Atherosclerosis is the leading cause of death in patients with progressive kidney disease (Balla et al. ).…”

Section: Introductionmentioning

confidence: 99%

“…NOS, particularly the endothelial isoform (eNOS, NOS3), is a critical component for endothelial function and is antiatherogenic (Kuhlencordt et al 2001). Atherosclerosis is the leading cause of death in patients with progressive kidney disease (Balla et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Differential regulation of nitric oxide synthase function in aorta and tail artery from 5/6 nephrectomized rats

et al. 2013

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Chronic renal failure (CRF) is associated with hypertension and concomitant endothelial dysfunction, enhanced vasoconstriction, and nitric oxide synthase (NOS) dysfunction. Vascular function in patients is assessed in peripheral extremity arteries like the finger arteries, whereas animal studies often use the centrally located aorta. Therefore, we examined whether peripheral tail artery and aortic NOS function are differentially regulated by blood pressure in rats with CRF. Using wire myography, arterial function was assessed in 16-week-old Sprague-Dawley rats that were subjected to 5/6 nephrectomy (Nx; arterial ligation model) 8 weeks earlier or non-Nx (control) rats. In aortas from Nx rats, endothelial-dependent vasorelaxation response to acetylcholine (ACh) was blunted and there was enhancement of phenylephrine (PE)-mediated vasoconstriction. Inversely, tail arteries from Nx rats had no change in endothelial function and reduced response to PE. Studies where arterial segments were incubated with the nonspecific NOS inhibitor, L-NAME, showed that Nx reduced NOS function in the aorta but increased NOS function in tail artery for both ACh and PE responses. Furthermore, the observed alterations in NOS function in both aorta and tail artery were abolished when mean arterial blood pressure, as assessed by telemetry, was maintained at normal levels in the 5/6 Nx rats using triple therapy: hydralazine (30 mg/kg per day), hydrochlorothiazide (10 mg/kg per day), and reserpine (0.5 mg/kg per day). In conclusion, differential changes of NOS function in central versus peripheral arteries in CRF are dependent upon hypertension.

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“…[10] The infrarenal abdominal aorta is prone to the development of atherosclerotic plaque and its complications including obstruction, ulceration, thrombus formation, and potentially, aneurysmal degeneration. [11] The spontaneous thrombosis of aortic aneurysm is rare.…”

Section: Discussionmentioning

confidence: 99%

Partially thrombosed aneurysm of the abdominal aorta: Unusual cause of chronic inflammation and resistance to recombinant human erythropoietin

2014

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Diagnosis of chronic inflammatory syndrome is often a challenge. In dialysis patients, this condition leads to resistance to recombinant human erythropoietin (rHuEPO). We here report a case of a 72-year-old male undergoing chronic hemodialysis and developed rHuEPO resistance without any obvious etiology. Investigations showed a partially thromosed aneurysm of the infrarenal aorta. Antiplatelet therapy was started with a satisfactory outcome.

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Risk factors for atherosclerosis in patients with chronic kidney disease: recognition and management

Cited by 33 publications

References 29 publications

Indoxyl sulfate stimulates oxidized LDL uptake through up-regulation of CD36 expression in THP-1 macrophages

Indoxyl sulfate stimulates oxidized LDL uptake through up-regulation of CD36 expression in THP-1 macrophages

Differential regulation of nitric oxide synthase function in aorta and tail artery from 5/6 nephrectomized rats

Partially thrombosed aneurysm of the abdominal aorta: Unusual cause of chronic inflammation and resistance to recombinant human erythropoietin

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