Risk factors for asthma after infant bronchiolitis

Abstract

After bronchiolitis at less than 6 months of age, the risk of doctor-diagnosed asthma at 11-13 years was about twice that of the general Finnish population. Maternal asthma was the only independently significant early-life risk factor for current asthma at 11-13 years of age.

Interleukin‐10 polymorphisms were not associated with lung function at age 11‐13 years after infant bronchiolitis

“…We have prospectively followed 166 children hospitalised for bronchiolitis at under six months of age. Of them, 138 attended the study visit at 11‐13 years of age, and current asthma was present in 18 (13.0%), regular use of inhaled corticosteroids (ICS) during the last 12 months in 14 (10.1%), and asthma persisting from 5‐7 years of age in 11 (8.0%) cases . The variant genotype AG or GG of the IL‐10 rs1800896 was associated with less asthma persisting from 5‐7 to 11‐13 years (4.3% vs 15.2%) and less ICS use during last 12 months (5.4% vs 18.2 %) than the wild genotype …”

“…In this paper, baseline and post‐bronchodilator FEV1 and FEV1/FVC were studied in relation to the IL‐10 gene rs1800896, rs1800871, rs1800872 and rs1800890. We have previously published the details of the study subjects at 11‐13 years of age, the association of clinical findings with the four IL‐10 gene polymorphisms including the genetic methods, and lung function findings including the description of the used flow‐volume spirometry …”

“…Of them, 138 attended the study visit at 11-13 years of age, and current asthma was present in 18 (13.0%), regular use of inhaled corticosteroids (ICS) during the last 12 months in 14 (10.1%), and asthma persisting from 5-7 years of age in 11 (8.0%) cases. 3 The variant genotype AG or GG of the IL-10 rs1800896 was associated with less asthma persisting from 5-7 to 11-13 years (4.3% vs 15.2%) and less ICS use during last 12 months In this post-bronchiolitis cohort, the IL-10 rs1800896, rs1800871 and rs1800872 genotype combination AA+CT+CA and carriage of haplotype ATA, respectively, were associated with higher resistance and lower reactance in baseline impulse oscillometry at 5-7 years of age. 2 In the IL-10 rs1800890, the wild genotype AA was associated with lower reactance in baseline.…”

Preliminary communication suggests overweight was associated with reduced lung function in adolescence after infant bronchiolitis

“…Asthma controller medication was not interrupted . After baseline blows, the children inhaled 0.1 mg salbutamol (Ventoline, GlaxoSmithKline, London, UK) four times through a spacer before the post‐bronchodilator blows . The spirometry parameters were presented as percentages of predicted of population‐based, sex‐specific, height‐related references.…”

“…The pathological limits for categorised FVC, FEV1 and FEV1/FVC are presented in Table . Current asthma was considered to be present if the child had used regularly inhaled corticosteroids during the preceding 12 months or if the child had suffered from asthma‐presumptive symptoms during the preceding 12 months with an increase 12% or more in the bronchodilation test .…”