Risk factors for aneurysm rupture among Kazakhs: findings from a national tertiary hospital

Medetov, Yerkin; Babi, Aisha; Makhambetov, Yerbol; Menlibayeva, Karashash; Bex, Torekhan; Kaliyev, Assylbek; Akshulakov, Serik

doi:10.1186/s12883-022-02892-y

Cited by 6 publications

(3 citation statements)

References 39 publications

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“…Consequently, atherosclerosis may be the etiology of SAH in this patient ( 19 , 20 ). Furthermore, the patient had a history of hypertension and irregular control of blood pressure may be one of the factors for inducing aneurysm rupture ( 21 , 22 ). In the present case, acute paraplegia developed immediately after the onset of aneurysmal SAH and the possibility of hemorrhage causing spinal vasospasm was considered.…”

Section: Discussionmentioning

confidence: 99%

Acute paraplegia after aneurysmal subarachnoid hemorrhage: Case report of a rare complication with a 2‑year follow‑up

et al. 2023

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The current overall incidence of subarachnoid hemorrhage (SAH) is ~9/100,000 individuals/year and rupture of an intracranial aneurysm is the main cause of SAH, accounting for ~85% of cases. Only a small number of cases of paraplegia after intracranial aneurysmal SAH have so far been reported and its pathogenesis has remained to be fully elucidated. The present study reports the case of a patient with an aneurysm localized in the medial and inferior lateral wall of the C5 segment of the right internal carotid artery that was treated by coil interventional embolization. The muscle strength of both lower extremities of the patient was grade I and grade 0 before and after the operation, respectively. Lumbar and thoracic magnetic resonance imaging examinations revealed slight hematoma in the subarachnoid space below the L2 level. At two weeks after the operation, the muscle strength of both lower extremities was grade II, while the muscle strength was grade III and grade V at 30 and 60 days after the operation, respectively.

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Section: Discussionmentioning

confidence: 99%

Acute paraplegia after aneurysmal subarachnoid hemorrhage: Case report of a rare complication with a 2‑year follow‑up

et al. 2023

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“…Its high mortality and prevalence in cardiovascular diseases have garnered significant attention. In Central and Eastern European countries, the estimated incidence of CA among adults is 3.2% [4,5]. The multifaceted pathogenesis of cerebral aneurysms involves various factors, including genetic predisposition, hemodynamic stress, and environmental influences [6].…”

Section: Introductionmentioning

confidence: 99%

Unraveling the role of <i>LDHA</i> and <i>VEGFA</i> in oxidative stress: A pathway to therapeutic interventions in cerebral aneurysms

Wu,

Lu,

Dai

et al. 2024

Biomol Biomed

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Cerebral aneurysms (CA) are critical conditions often associated with oxidative stress in vascular endothelial cells (VECs). The enzyme lactate dehydrogenase A (LDHA) plays a crucial role in glycolysis and lactate metabolism, processes implicated in the pathogenesis of aneurysms. Understanding these molecular mechanisms can inform the development of novel therapeutic targets. This study investigated the role of lactate metabolism and lactate-related genes, particularly LDHA and vascular endothelial growth factor A (VEGFA) genes, in VECs during oxidative stress. Using the GSE26969 dataset, we identified differential expression of lactate-related genes and performed functional enrichment analysis, revealing significant associations with glycolysis and lactate metabolic pathways. To induce oxidative stress, VECs were treated with H2O2, and the expression of LDHA and VEGFA was analyzed using quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting (WB) assays. Under oxygen-glucose deprivation/reperfusion (OGD/R) conditions, the effects of LDHA overexpression and VEGFA knockdown on cell viability and apoptosis were evaluated. Immunoprecipitation combined with western blotting was used to detect the lactylation status of LDHA following OGD/R stimulation and treatment with lactic acid (LA) and 2-deoxyglucose (2-DG). Our results indicated that oxidative stress modulates LDHA expression, glucose uptake, and lactate production, suggesting a metabolic shift towards glycolysis. LDHA overexpression improved cell survival and reduced apoptosis, while VEGFA knockdown had the opposite effect. Additionally, 2-DG treatment reduced LDHA lactylation and apoptosis. Our findings demonstrated that LDHA plays a critical role in the oxidative stress response of VECs, highlighting the potential therapeutic value of targeting glycolysis in CA. This study contributes to the understanding of metabolic adaptations in vascular pathologies and suggests new avenues for therapeutic intervention in CA management.

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“…Following publication of the original article [ 1 ], the authors reported an error in the article title. The word “hospital” is missing.…”

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confidence: 99%

Correction: Risk factors for aneurysm rupture among Kazakhs: findings from a national tertiary hospital

Medetov¹,

Babi

Makhambetov³

et al. 2022

BMC Neurol

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Risk factors for aneurysm rupture among Kazakhs: findings from a national tertiary hospital

Cited by 6 publications

References 39 publications

Acute paraplegia after aneurysmal subarachnoid hemorrhage: Case report of a rare complication with a 2‑year follow‑up

Acute paraplegia after aneurysmal subarachnoid hemorrhage: Case report of a rare complication with a 2‑year follow‑up

Unraveling the role of <i>LDHA</i> and <i>VEGFA</i> in oxidative stress: A pathway to therapeutic interventions in cerebral aneurysms

Correction: Risk factors for aneurysm rupture among Kazakhs: findings from a national tertiary hospital

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