Risk factors for anastomotic leak and postoperative morbidity and mortality after elective right colectomy for cancer: results from a prospective, multicentric study of 1102 patients

Frasson, Matteo; Granero-Castro, Pablo; Rodríguez, José Luis Ramos; Flor-Lorente, Blas; Braithwaite, Mariela; Martínez, E.; Pérez, Julio C.; Cazador, Antonio Codina; Espí, Alejandro; García‐Granero, Eduardo

doi:10.1007/s00384-015-2376-6

Cited by 137 publications

(124 citation statements)

References 38 publications

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“…In concordance with findings from the literature [1][2][3], almost 20% of all colon cancer resections in the Netherlands are performed in a nonelective setting. The present results show an anastomotic leakage rate of 6.4% after colon resection, comparable to the rates from the literature which vary from 3% to 6.5% [11,[18][19][20]. When comparing the outcome after elective and nonelective resection, anastomotic leakage showed a slight, but clinically insignificant, rise from 6.4% to 7.1%.…”

Section: Discussionsupporting

confidence: 84%

High mortality rates after nonelective colon cancer resection: results of a national audit

et al. 2016

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Section: Discussionsupporting

confidence: 84%

High mortality rates after nonelective colon cancer resection: results of a national audit

et al. 2016

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“…Compared with other countries, China has the most overweight people (more than 89.6 million in 2014) . Obesity has been associated with a high incidence of post‐abdominal surgery complications, such as anastomotic leakage, wound infection, and pneumonia . However, this is the first study to determine the relationship between obesity and PGS.…”

Section: Discussionmentioning

confidence: 91%

A quantified risk‐scoring system and rating model for postsurgical gastroparesis syndrome in gastric cancer patients

Chen

Mao

Zhang

et al. 2017

Journal of Surgical Oncology

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“…Incisional SSI has been associated with increased body mass index or the presence of an ostomy [6, 9]. On the other hand, OS-SSI has been more frequently related to blood transfusion, previous abdominal surgery or poor nutritional status [6, 7, 10]. Interestingly, the development of an OS-SSI has more severe consequences than the development of an I-SSI; in many cases OS-SSI requires reoperation and increases morbidity and length of stay (LOS) [11, 12].…”

Section: Introductionmentioning

confidence: 99%

Risk factors and outcomes of organ-space surgical site infections after elective colon and rectal surgery

Gomila-Grange

Carratalà

Camprubí

et al. 2017

Antimicrob Resist Infect Control

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BackgroundOrgan-space surgical site infections (SSI) are the most serious and costly infections after colorectal surgery. Most previous studies of risk factors for SSI have analysed colon and rectal procedures together. The aim of the study was to determine whether colon and rectal procedures have different risk factors and outcomes for organ-space SSI.MethodsA multicentre observational prospective cohort study of adults undergoing elective colon and rectal procedures at 10 Spanish hospitals from 2011 to 2014. Patients were followed up until 30 days post-surgery. Surgical site infection was defined according to the Centers for Disease Control and Prevention criteria. Oral antibiotic prophylaxis (OAP) was considered as the administration of oral antibiotics the day before surgery combined with systemic intravenous antibiotic prophylaxis.ResultsOf 3,701 patients, 2,518 (68%) underwent colon surgery and 1,183 (32%) rectal surgery. In colon surgery, the overall SSI rate was 16.4% and the organ-space SSI rate was 7.9%, while in rectal surgery the rates were 21.6% and 11.5% respectively (p < 0.001). Independent risk factors for organ-space SSI in colon surgery were male sex (Odds ratio -OR-: 1.57, 95% CI: 1.14–2.15) and ostomy creation (OR: 2.65, 95% CI: 1.8–3.92) while laparoscopy (OR: 0.5, 95% CI: 0.38–0.69) and OAP combined with intravenous antibiotic prophylaxis (OR: 0.7, 95% CI: 0.51–0.97) were protective factors. In rectal surgery, independent risk factors for organ-space SSI were male sex (OR: 2.11, 95% CI: 1.34–3.31) and longer surgery (OR: 1.49, 95% CI: 1.03–2.15), whereas OAP with intravenous antibiotic prophylaxis (OR: 0.49, 95% CI: 0.32–0.73) was a protective factor. Among patients with organ-space SSI, we found a significant difference in the overall 30-day mortality, being higher in colon surgery than in rectal surgery (11.5% vs 5.1%, p = 0.04).ConclusionsOrgan-space SSI in colon and rectal surgery has some differences in terms of incidence, risk factors and outcomes. These differences could be considered for surveillance purposes and for the implementation of preventive strategies. Administration of OAP would be an important measure to reduce the OS-SSI rate in both colon and rectal surgeries.

show abstract

Risk factors for anastomotic leak and postoperative morbidity and mortality after elective right colectomy for cancer: results from a prospective, multicentric study of 1102 patients

Cited by 137 publications

References 38 publications

High mortality rates after nonelective colon cancer resection: results of a national audit

High mortality rates after nonelective colon cancer resection: results of a national audit

A quantified risk‐scoring system and rating model for postsurgical gastroparesis syndrome in gastric cancer patients

Risk factors and outcomes of organ-space surgical site infections after elective colon and rectal surgery

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