Risk factors for adverse events during collection of peripheral blood stem cells

Procedure‐related complications and adverse events associated with pediatric autologous peripheral blood stem cell collection

“…Citrate was the most common AE encountered, with at least one citrate AE observed in 25% of children. This is consistent with prior pediatric (7–25%, Table ) and adult studies . In our study, the risk of citrate AE was higher in older and heavier patients, who often required several procedures (Fig.…”

“…Children are often perceived to tolerate HPCC better than adults, with significantly less G‐CSF toxicity . In adults, procedure‐associated AE average 9–13% per procedure and 12% to 42% per patient, with higher rates observed in women and low body weights . In healthy pediatric donors, procedural AE rates range from 20 to 40% per patient , which is compatible with our results (39%).…”

“…B). Like adults , citrate AE tended to be more common in females although the difference did not reach clinical significance (30% vs. 15.6% males, P = 0.18). There was no correlation between citrate AE by patient diagnosis ( P = 0.19‐0.47).…”

Paroxysmal atrial fibrillation caused by hypokalemia in a healthy donor who underwent PBSC apheresis

“…10 In our case, we can exclude an excessive citrate toxicity, which may be due to the high ratio of ACD/weight and the large number of procedures, as well as to the female gender. 11 Our female donor underwent only one apheresis, and the ratio ACD/weight was equal to 10.8 mL/kg, well below the average of 14.21 reported in the study of Domnez. 11 Unfortunately, we cannot confirm that the alkalosis is caused by hypokalemia, nor can we quantify the urinary losses of potassium.…”

“…11 Our female donor underwent only one apheresis, and the ratio ACD/weight was equal to 10.8 mL/kg, well below the average of 14.21 reported in the study of Domnez. 11 Unfortunately, we cannot confirm that the alkalosis is caused by hypokalemia, nor can we quantify the urinary losses of potassium. The plasma pH measurements and the urinalysis post PBSCa are not known: these laboratory tests usually are not performed in healthy donors.…”