Risk factors, epidemiology and prognosis of cholangiocarcinoma in Finland

Barner-Rasmussen, Nina; Pukkala, Eero; Hadkhale, Kishor; Färkkilä, Martti

doi:10.1002/ueg2.12154

Cited by 23 publications

(26 citation statements)

References 40 publications

(53 reference statements)

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“…A systematic review and meta-analysis showed that cysts and stones in the bile ducts were risk factors for ICC and ECC 6 . Moreover, a study in Mexico showed that primary sclerosing cholangitis (PSC) was a positive risk factor for developing ICC 7 , and a study in Finland also indicated that PSC was associated with both ICC and ECC 8 .…”

Section: Introductionmentioning

confidence: 99%

Associations between ultrasound screening findings and cholangiocarcinoma diagnosis in an at-risk population

Thinkhamrop

Khuntikeo

Chamadol

et al. 2022

Sci Rep

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The rate of cholangiocarcinoma (CCA) is increasing every year, especially in northeastern Thailand. Screening for CCA using ultrasonography (US) is the fastest technique to identify patients in early stage of CCA development. Currently, few studies have examined patterns of hepatobiliary abnormalities identified using US, which can be indicative of CCA. We aim to evaluate the rate of CCA and its relations to history of US findings. Our study included participants who underwent US and pathological diagnosis of CCA from the Cholangiocarcinoma Screening and Care Program, Northeast Thailand between 2013 and 2020. Data on histological findings were based on the standard protocol of the tertiary hospital at Khon Kaen University. CCA data is categorized into two groups (yes/no) to find the relationship with history of US findings. The adjusted odds ratio (AOR) and their 95% confidence intervals (CI) were used to evaluate the relationship obtained by multiple logistic regression. Of 1880 subjects who underwent US and a pathological diagnosis of CCA, the overall rate of CCA was 35.74%. CCA rate among those with liver mass (LM) was 54.85% and with dilated bile duct (DBD) was 62.01%. The relationship between DBD and CCA was highly significant (AOR = 3.46; 95% CI 2.74–4.36) followed by LM (AOR = 2.28; 95% CI 1.81–2.86) P value < 0.001. Our study reveals that US findings history have a strong association with CCA, especially in people diagnosed with DBD and LM. Therefore, these abnormalities can be indicators for suspected CCA diagnosis through US.

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Section: Introductionmentioning

confidence: 99%

Associations between ultrasound screening findings and cholangiocarcinoma diagnosis in an at-risk population

Thinkhamrop

Khuntikeo

Chamadol

et al. 2022

Sci Rep

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“…Another established risk factor in our study is cholelithiasis, and it also has been identified as a prominent CCA risk factor, especially for eCCA (extrahepatic CCA) in many studies (Cai et al, 2015;Clements et al, 2020;Barner-Rasmussen et al, 2021) and a possible explanation for its CCA-promoting mechanism should be the continuous chronic inflammation of bile duct caused by gallstones (Brindley et al, 2021). Furthermore, its risk effect on CCA might decline with time after cholecystectomy (Nordenstedt et al, 2012), which equals to removing the chronic inflammatory stimulus.…”

Section: Discussionmentioning

confidence: 58%

Examination on the risk factors of cholangiocarcinoma: A Mendelian randomization study

et al. 2022

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Background: Several risk factors have been identified for CCA, however, whether such associations were causal remains unknown.Methods: Mendelian randomization (MR) has been applied to examine the causal relationship between 26 putative risk factors and CCA. The genetic variants for each risk factor were extracted from their corresponding genome-wide association study (GWAS) if they reached the genome-wide significance (p-value < 5 × 10−8). The genetic associations with CCA were obtained from the publicly available GWAS with the largest sample size. Mainly, inverse-variance weighted (IVW) has been adopted to estimate the causal effect on CCA. Both multivariable and mediation MR analyses were carried out to detect independent factors.Results: Three putative risk factors can causally elevate the risk of CCA after FDR correction, including liver fat content (LFC), non-alcoholic fatty liver disease (NAFLD), and cholelithiasis. The odds of CCA would increase per 1-SD increase in the liver fat content (LFC) (OR = 2.12 [1.66, 2.71]) and logOR of NAFLD. The genetic liability to cholelithiasis would increase the risk of CCA as well (OR = 2.17 [1.47, 3.20]). They were still significant in other methods. The multivariable MR analysis indicated that genetically-elevated LFC should increase the risk of CCA independently of cholelithiasis (OR = 1.88 [1.39, 2.55]). In the mediation MR analysis, the indirect effect was not significant when treating cholelithiasis as the mediator (indirect OR = 0.95 [0.85, 1.07]).Conclusion: This MR study identified that gallstone and liver fat accumulation are two independent risk factors of CCA, suggesting two modifiable ways of preventing CCA.

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“…Also, the patient is undergoing chemotherapy as the diagnosis was made swiftly, and the patient responded positively to the treatment. One of the research projects by Barner-Rasmussen et al stated that the prevalence of the disease is comparatively more in males than females [ 12 ]. It also depends upon the patient’s age; as the patient's age increase, the chances of disease causation increase [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

A Typical Case of an Atypical Disease: Klatskin Tumor

Agrawal¹,

Lamture²,

Totade³

2022

Cureus

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Cholangiocarcinoma is a rare type of cancer disorder. The case report is of a 55-years-old male patient who came to the output patient department (OPD) with complaints of abdominal pain and weight loss for 15 days and later was diagnosed with Klatskin tumor after mandatory investigations. After the approval of the tumor board committee, he is under chemotherapy, to which he is responding positively. Klatskin tumor is a type of cholangiocarcinoma occurring at the convergence of the right and left lobes of hepatic bile ducts, forming the common bile duct. The source of cholangiocarcinoma is idiopathic, and most cholangiocarcinoma is treated with the help of either surgical resection or chemotherapy. Surgical resection is performed in initial cases, but most patients present with the advanced stage of Klatskin tumor. CA-19-9 is a tumor marker that indicates the presence of a Klatskin tumor.

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Risk factors, epidemiology and prognosis of cholangiocarcinoma in Finland

Cited by 23 publications

References 40 publications

Associations between ultrasound screening findings and cholangiocarcinoma diagnosis in an at-risk population

Associations between ultrasound screening findings and cholangiocarcinoma diagnosis in an at-risk population

Examination on the risk factors of cholangiocarcinoma: A Mendelian randomization study

A Typical Case of an Atypical Disease: Klatskin Tumor

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